Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2 [0.03%]
加热烟草产品烟雾提取物的细胞毒性作用对人类口腔鳞状细胞癌的作用：反应性氧合物种和CaMKK2的作用机制探究
Nagao Kagemichi,Masanari Umemura,Soichiro Ishikawa et al.
Nagao Kagemichi et al.
Background: The increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous studies have demonstrated the toxicity of cigarette smoke extract (CSE) from...
Age-related alteration of the involvement of CD36 for salivary secretion from the parotid gland in mice [0.03%]
小鼠年龄相关腮腺分泌中CD36作用的变化
Keitaro Satoh,Yuta Ohno,Haruna Nagase et al.
Keitaro Satoh et al.
This in vivo mouse model study was conducted to investigate the temporal alteration of the function of CD36 in salivary secretion. CD36 was highly expressed in the parotid gland of BALB/c mice. No significant variations were shown in the CD...
Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect [0.03%]
甲状腺腺瘤相关蛋白（THADA）在强心苷诱导的抗癌作用中的负向调控
Mizuki Katoh,Takuto Fujii,Yoshiaki Tabuchi et al.
Mizuki Katoh et al.
Cardiac glycosides, known as inhibitors of Na+,K+-ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of cancer cell death. Here, we examined the signaling pathway elicited by cardiac glycosides i...
Yutaro Oguma,Toshi Nakajima,Megan Elizabeth Young et al.
Yutaro Oguma et al.
Experiments measuring evoked potentials require flexible and rapid adjustment of stimulation and recording parameters. In this study, we have developed a recording system and an associated Android application that allow making such adjustme...
Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice [0.03%]
母系暴露全氟辛烷磺酸阴离子对子代小鼠成年后脑功能的影响及其作用机制研究
Ayane Ninomiya,Izuki Amano,Hiraku Suzuki et al.
Ayane Ninomiya et al.
Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life PFOS exposure holds a potential risk for developing age-related neurodegenerative diseases suc...
Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats [0.03%]
嘌呤通过P2Y受体和ATP依赖性钾通道抑制大鼠食管平滑肌的收缩
Takahiko Shiina,Yuji Suzuki,Kazuhiro Horii et al.
Takahiko Shiina et al.
Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was...
Effects of cytochalasin D on relaxation process of skinned taenia cecum and carotid artery from guinea pig [0.03%]
CYTOCHALASIN D对 Guinea Pig 乙状结肠和颈动脉去密肌丝肌肉条松弛过程的影响
Satoko Mihashi,Masaru Watanabe
Satoko Mihashi
Actin linked regulatory mechanisms are known to contribute contraction/relaxation in smooth muscle. In order to clarify whether modulation of polymerization/depolymerization of actin filaments affects relaxation process, we examined the eff...
Identification of three distinct cell populations for urate excretion in human kidneys [0.03%]
识别人类肾脏中促进尿酸排泄的三种不同细胞群
Yoshihiko M Sakaguchi,Pattama Wiriyasermkul,Masaya Matsubayashi et al.
Yoshihiko M Sakaguchi et al.
In humans, uric acid is an end-product of purine metabolism. Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal urate transporters. However, it...
An interactive simulator to deepen the understanding of Guyton's venous return curve [0.03%]
一个互动模拟器深化对盖顿静脉回流曲线的理解
Noritaka Mamorita,Akihiro Takeuchi,Hirotoshi Kamata
Noritaka Mamorita
Mean circulatory filling pressure, venous return curve, and Guyton's graphical analysis are basic concepts in cardiovascular physiology. However, some medical students may not know how to view and interpret or understand them adequately. To...
Evaluation of colour vision impairment during acute hypobaric hypoxia in aviation medicine: a randomized controlled trial [0.03%]
航空医学中急性低气压缺氧期间色觉损伤的评估：一项随机对照试验
F Liebold,W Adler,S Jansen et al.
F Liebold et al.
The digitization of aircraft cockpits places high demands on the colour vision of pilots. The present study investigates colour vision changes upon acute exposure to hypobaric hypoxia. The digital Waggoner Computerized Color Vision Test and...
Randomized Controlled Trial
The journal of physiological sciences : JPS. 2024;74(1):6. DOI:10.1186/s12576-024-00898-4 2024