Activation of aortic baroreceptors depresses the somato-lumbar sympathetic reflex, reducing hindlimb muscle contractile force [0.03%]
主动脉球囊扩张激活颈动脉窦甲肾上腺素能神经元抑制交感传出至下肢肌肉神经元
Nobuhiro Watanabe,Kotaro Takeno,Naoko H Tomioka et al.
Nobuhiro Watanabe et al.
We investigated whether the same sympathetic nerves innervate arteries and neuromuscular junctions and aortic baroreceptor stimulation reduces muscle force in rats. Histological analysis with fluorescent labeling revealed nicotinic acetylch...
Toward the promotion of "One Health" - part I: How do humans work to live together with humans, other organisms, and xenobiotics on Earth? [0.03%]
迈向“同一个健康”（One Health）——第一部分：人类如何在地球上与人、其他生物及外源物质共同生存？
Yumiko Imai,Shunsuke Kimura,Satoshi Kitajima et al.
Yumiko Imai et al.
Thirty years from now, society will be transformed by dramatic advances in digital transformation, life infrastructure, and personalized medicine. People will communicate seamlessly in virtual spaces, and older adults will enjoy more fulfil...
METTL14-mediated m6A modification of DUSP6 mRNA participating in postoperative cognitive dysfunction due to sevoflurane anesthesia [0.03%]
METTL14介导的DUSP6 mRNA m6A修饰参与异氟醚麻醉术后认知障碍
Shengfeng Deng,Guo Mu,Jun Li et al.
Shengfeng Deng et al.
Background: To investigate the mechanisms underlying sevoflurane-induced POCD, C57BL/6 J mice and SH-SY5Y cells were treated with sevoflurane for model establishment. ...
Macrophage depletion lowers blood pressure and reduces renal fibrosis progression in existing hypertension mice model [0.03%]
巨噬细胞耗竭可降低高血压小鼠模型血压并减少肾纤维化进展
Joseph Kasyoki Peter,Ryusuke Umene,Chia-Hsien Wu et al.
Joseph Kasyoki Peter et al.
Uncontrolled hypertension is a global health issue with 40 % of hypertensive patients not achieving blood pressure control with current therapies. Previously, we demonstrated renal macrophage infiltration during hypertension development wit...
Estrogen-dependent effects of vagotomy and endogenous opioids on temporomandibular joint-responsive neurons in trigeminal subnucleus caudalis [0.03%]
卵圆孔切术后内源性阿片肽对三叉神经脊束核下亚核颞下颌关节反应神经元的雌激素依赖效应
Akimasa Tashiro,David A Bereiter,Yuna Kani et al.
Akimasa Tashiro et al.
Temporomandibular joint (TMJ) disorders are common orofacial pain conditions influenced by multiple factors. This study examined how vagotomy and endogenous opioids affect TMJ-responsive neurons in the trigeminal subnucleus caudalis/cervica...
LAMC1 aggravates diabetic retinopathy through PI3K/AKT signaling-regulated epithelial-mesenchymal transition in retinal pigment epithelial cells [0.03%]
LAMC1通过PI3K/AKT信号调节的上皮间质转化加重糖尿病性视网膜病变
Lei Liu,Yanlin Gao,Shiqi Yao
Lei Liu
Diabetic retinopathy (DR), a leading cause of adult blindness, with LAMC1-mediated epithelial-mesenchymal transition (EMT) playing a key role. By analyzing DR-related microarray datasets (GSE60436/GSE102485) from GEO, we identified 685 diff...
Estradiol enhances thermoregulation induced by ostruthin, a TREK channel agonist, in ovariectomized rats [0.03%]
雌二醇增强卵巢切除大鼠由Ostruthin诱导的热调节作用
Yuki Uchida,Shotaro Kamijo,Yuki Samejima et al.
Yuki Uchida et al.
Menopausal women frequently report contradictory thermoregulatory symptoms (hot flashes and chills), believed to result from declining estradiol (E₂) levels; however, mechanisms remain unclear. TWIK-related (TREK) potassium channels functi...
Incompleteness of the circle of Willis affects sleep quality, cognitive function and inflammation in patients with primary hypertension [0.03%]
圈套不完整的患者原发性高血压影响睡眠质量，认知功能和炎症
Ying Feng,Xueqi Yang,Yang Song et al.
Ying Feng et al.
To investigate whether incomplete Circle of Willis (Incomplete CoW) affects neuropsychological outcomes in patients with primary hypertension, a cross-sectional study was conducted involving 150 patients diagnosed with primary hypertension,...
ATF4 transcriptionally activates NUPR1 to promote ferroptosis in chondrocytes and osteoarthritis development [0.03%]
转录因子ATF4通过激活NUPR1促进软骨细胞铁死亡及骨关节炎发生发展
Chen Kuang,Taiyang Liao,Lishi Jie et al.
Chen Kuang et al.
Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage destruction and inflammation. This study reveals that activating transcription factor 4 (ATF4) is upregulated in IL-1β-treated chondrocytes and promotes ...
Podoplanin hetero-insufficiency mice with inflammation in the jejunum demonstrates a good animal model of congenital protein-losing enteropathy [0.03%]
podoplanin杂合子不足小鼠结肠炎是获得性小肠蛋白丢失性肠病的良好动物模型
Toshio Ohhashi,Nagaharu Tsukiji,Moyuru Hayashi et al.
Toshio Ohhashi et al.
We have identified the Podoplanin expression in rat jejunal villi. We aimed to investigate the relationship between the Podoplanin expression in jejunal villi and the pathogenesis of congenital protein-losing enteropathy (PLE), using the Po...