Promoting arousal associated with physical activity with the vitamin B1 derivative TTFD [0.03%]
维生素B1衍生物TTFD促进与体育活动相关的唤醒程度
Toshiaki Hata,François Grenier,Taichi Hiraga et al.
Toshiaki Hata et al.
Physical inactivity, which is a global issue, reduces physical and mental vitality, particularly impairing prefrontal-cortex-based mental health. This may trigger social withdrawal and depression, hindering the ability to have an active lif...
Rebastinib inhibits FoxO1 activity and reduces dexamethasone-induced atrophy and its-related gene expression in cultured myotubes [0.03%]
雷巴司汀抑制FoxO1活性及其相关基因的表达并减少培养肌管中地塞米松诱导的萎缩
Tomoki Sato,Akihito Morita,Yui Watanabe et al.
Tomoki Sato et al.
FoxO1, a transcription factor, is upregulated in skeletal muscle during atrophy and inactivation of FoxO1 is a potential strategy to prevent muscle loss. This study identified Rebastinib as a potent suppressor of FoxO1 activity among protei...
Makoto Tominaga,Moe Iwata
Makoto Tominaga
TRPA1 was first identified as a noxious cold receptor in mice in 2003. Multiple TRPA1 genes have since been isolated, indicating that TRPA1 emerged early in evolution and showing the existence of TRPA1 variants in a range of species, includ...
Single acupressure on ST36 does not modulate skin blood flow and sympathetic nerve activity during and after cold stimulation of the hand [0.03%]
单纯按压ST36点在手冷刺激过程中和之后对皮肤血流和交感神经活动没有影响
Hironori Watanabe,Mitsuko Hanaoka,Taisuke Sugi et al.
Hironori Watanabe et al.
Acupressure on ST36 (Zusanli), located on the lower leg, commonly used to optimize autonomic nerve activity and systemic blood flow in traditional Chinese medicine. However, its efficacy remains controversial. This study hypothesized that a...
Circadian sleep-wake rhythm reversal in mice implanted with stomach cancer cell lines [0.03%]
胃癌细胞系植入小鼠的昼夜睡眠觉醒节律倒置现象研究
Motohide Goto,Takashi Maruyama,Miki Nonaka et al.
Motohide Goto et al.
The present study explored the phenotype and behavioral characteristics of mice implanted with the 85As2 human stomach cancer cell lines. Generally, mice are nocturnal; they are active during the dark phase and resting in the light phase. H...
Makoto Tominaga,Moe Iwata
Makoto Tominaga
The capsaicin receptor TRPV1 was identified as the first heat-activated ion channel in 1997. Since then, numerous studies have been performed on its physiological functions and structure-function relationship, and chemicals targeting TRPV1 ...
The difference in arterial baroreflex sensitivity between the supine and standing positions in healthy subjects [0.03%]
健康受试者仰卧位和直立位动脉血压心率反射敏感性差异的实验研究
Teruhiko Sakamoto,Satoshi Mitsuyama,Toru Nagasawa et al.
Teruhiko Sakamoto et al.
The spectral analysis of heart rate variability (HRV) has long been considered a practical, noninvasive tool to assess autonomic nervous functions that regulate the cardiovascular system. The conventional method, however, has limitations in...
US-Japan NVU Workshop Group. Electronic address: nakahara@a.keio.jp; US-Japan NVU Workshop Group
US-Japan NVU Workshop Group. Electronic address: nakahara@a.keio.jp; US-Japan NVU Workshop Group
The joint workshop between U.S. and Japanese researchers, supported by The U.S.-Japan Brain Research Cooperative Program, convened in January 2023 at Keio University Mita campus in Tokyo, Japan. The workshop had a threefold objective. First...
Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals [0.03%]
性别对年轻个体被动抬腿试验诱发交感血管反应的影响研究
Keisho Katayama,Kana Shiozawa,Jordan B Lee et al.
Keisho Katayama et al.
The purpose of this study was to clarify sex differences in the inhibition of sympathetic vasomotor outflow which is caused by the loading of cardiopulmonary baroreceptors. Ten young males and ten age-matched females participated. The parti...
Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part: focusing on NMDA receptor [0.03%]
GABAB受体对口腔部分躯体感觉皮层局部网络振荡的作用：着重于N-甲基-D天冬氨酸受体的作用
Hiroyuki Kanayama,Takashi Tominaga,Yoko Tominaga et al.
Hiroyuki Kanayama et al.
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosenso...