Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals [0.03%]
性别对年轻个体被动抬腿试验诱发交感血管反应的影响研究
Keisho Katayama,Kana Shiozawa,Jordan B Lee et al.
Keisho Katayama et al.
The purpose of this study was to clarify sex differences in the inhibition of sympathetic vasomotor outflow which is caused by the loading of cardiopulmonary baroreceptors. Ten young males and ten age-matched females participated. The parti...
Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part: focusing on NMDA receptor [0.03%]
GABAB受体对口腔部分躯体感觉皮层局部网络振荡的作用：着重于N-甲基-D天冬氨酸受体的作用
Hiroyuki Kanayama,Takashi Tominaga,Yoko Tominaga et al.
Hiroyuki Kanayama et al.
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosenso...
Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2 [0.03%]
加热烟草产品烟雾提取物的细胞毒性作用对人类口腔鳞状细胞癌的作用：反应性氧合物种和CaMKK2的作用机制探究
Nagao Kagemichi,Masanari Umemura,Soichiro Ishikawa et al.
Nagao Kagemichi et al.
Background: The increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous studies have demonstrated the toxicity of cigarette smoke extract (CSE) from...
Age-related alteration of the involvement of CD36 for salivary secretion from the parotid gland in mice [0.03%]
小鼠年龄相关腮腺分泌中CD36作用的变化
Keitaro Satoh,Yuta Ohno,Haruna Nagase et al.
Keitaro Satoh et al.
This in vivo mouse model study was conducted to investigate the temporal alteration of the function of CD36 in salivary secretion. CD36 was highly expressed in the parotid gland of BALB/c mice. No significant variations were shown in the CD...
Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect [0.03%]
甲状腺腺瘤相关蛋白（THADA）在强心苷诱导的抗癌作用中的负向调控
Mizuki Katoh,Takuto Fujii,Yoshiaki Tabuchi et al.
Mizuki Katoh et al.
Cardiac glycosides, known as inhibitors of Na+,K+-ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of cancer cell death. Here, we examined the signaling pathway elicited by cardiac glycosides i...
Yutaro Oguma,Toshi Nakajima,Megan Elizabeth Young et al.
Yutaro Oguma et al.
Experiments measuring evoked potentials require flexible and rapid adjustment of stimulation and recording parameters. In this study, we have developed a recording system and an associated Android application that allow making such adjustme...
Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice [0.03%]
母系暴露全氟辛烷磺酸阴离子对子代小鼠成年后脑功能的影响及其作用机制研究
Ayane Ninomiya,Izuki Amano,Hiraku Suzuki et al.
Ayane Ninomiya et al.
Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life PFOS exposure holds a potential risk for developing age-related neurodegenerative diseases suc...
Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats [0.03%]
嘌呤通过P2Y受体和ATP依赖性钾通道抑制大鼠食管平滑肌的收缩
Takahiko Shiina,Yuji Suzuki,Kazuhiro Horii et al.
Takahiko Shiina et al.
Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was...
Effects of cytochalasin D on relaxation process of skinned taenia cecum and carotid artery from guinea pig [0.03%]
CYTOCHALASIN D对 Guinea Pig 乙状结肠和颈动脉去密肌丝肌肉条松弛过程的影响
Satoko Mihashi,Masaru Watanabe
Satoko Mihashi
Actin linked regulatory mechanisms are known to contribute contraction/relaxation in smooth muscle. In order to clarify whether modulation of polymerization/depolymerization of actin filaments affects relaxation process, we examined the eff...
Identification of three distinct cell populations for urate excretion in human kidneys [0.03%]
识别人类肾脏中促进尿酸排泄的三种不同细胞群
Yoshihiko M Sakaguchi,Pattama Wiriyasermkul,Masaya Matsubayashi et al.
Yoshihiko M Sakaguchi et al.
In humans, uric acid is an end-product of purine metabolism. Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal urate transporters. However, it...