Orai1- and STIM1-mediated calcium signaling controls PD-L1 expression and modulates antitumor immunity in oral cancer [0.03%]
口腔癌中ORAI1和STIM1介导的钙离子信号调控PD-L1表达并调节抗肿瘤免疫应答
Eriko Yamashita,Soichiro Ishikawa,Yuto Mizuno et al.
Eriko Yamashita et al.
This study investigated the regulation of PD-L1 expression by calcium signaling in oral squamous cell carcinoma (OSCC). We found that IFN-γ stimulation markedly altered the intracellular proteome and activated calcium-associated pathways. ...
Identification of a small molecule that targets activator of G-protein signaling 8 [0.03%]
一种靶向G蛋白信号激活因子8的小分子的鉴定
Alamgir Hossain,Aya Yamamura,Rie Takahashi et al.
Alamgir Hossain et al.
Activator of G-protein signaling 8 (AGS8), also known as fibronectin type III domain containing 1 (FNDC1), is an accessory protein for heterotrimeric G-proteins involved in various cellular processes. The interaction between AGS8 and Gβγ ...
Circadian feeding promotion by Ninjin'yoeito counteracts frailty in aged mice [0.03%]
ninjin-yoeito的昼夜促进食作用可抵抗小鼠衰老引起的衰弱症状
Lei Wang,Yermek Rakhat,Masanori Nakata et al.
Lei Wang et al.
Frailty in aging is a major health challenge, requiring solution. Older people with frailty often exhibit malnutrition and dysregulated feeding. Feeding behavior displays circadian rhythm, while aging and frailty involve rhythm disorders, s...
SIRT3-dependent enhancement of apelinergic signaling mediates the cardioprotective effects of late-life high-intensity interval training [0.03%]
长寿期高强度间歇训练的心脏保护作用依赖于Sirtuin 3介导的apelin信号通路增强效应
Qiaowei Li,Yanmei Song,Qin Liu et al.
Qiaowei Li et al.
Background: Deficiency in apelinergic signaling (APJ/Apelin) has been shown to accelerate cardiac aging. Given our observation that high-intensity interval training (HIIT) upregulates APJ and Apelin in aged mouse hearts, ...
Eric Mulder,Isak Löfquist,Felix Schagatay et al.
Eric Mulder et al.
Blackout (BO) in breath-hold diving is attributed to cerebral hypoxia, yet direct observations are rare. We continuously recorded arterial oxygen saturation (SpO₂) and heart rate (HR) in 11 trained freedivers (5 females) performing two dyn...
Effects of local skeletal muscle cooling prior to acute exercise and endurance training on mitochondrial adaptation in mice [0.03%]
局部肌肉冷却对小鼠急性运动和耐力训练诱导的线粒体适应的影响
Ryotaro Kano,Tatsuya Kusano,Taichi Ando et al.
Ryotaro Kano et al.
While post-exercise cooling is known to enhance skeletal muscle adaptations, the effects of pre-exercise cooling remain unclear. This study investigated whether local muscle cooling immediately before exercise augments training-induced mito...
Modulation of the association between blood glucose homeostasis and social hierarchy among co-housed mice by diet and amygdala activities [0.03%]
饮食和杏仁核活性对同笼小鼠血糖稳态和社会等级关联的调节作用研究
Rikako Ukichi,Yukari Takahashi,Momoyo Ibukuro et al.
Rikako Ukichi et al.
Recent clinical studies suggest that individual psychosocial traits play a significant role in the onset and progression of diabetes. To examine whether glucose homeostasis depends on the social rank of individual mice, we analyzed the effe...
EP4 stimulation promotes cell adhesion and migration via IL-6 signaling in oral squamous cell carcinoma [0.03%]
EP4刺激通过白介素-6信号促进口腔鳞癌细胞黏附和迁移
Wakana Fukae,Soichiro Ishikawa,Yu Iida et al.
Wakana Fukae et al.
Oral squamous cell carcinoma cell (OSCC) comprises malignant neoplasms arising within the oral cavity. Early-stage detection is associated with favorable prognosis, whereas progression to advanced stages with lymph node metastasis significa...
The intake of monosodium aspartate attenuates aggression induced by post-weaning social isolation in an ADHD rat model [0.03%]
天冬氨酸单钠盐的摄入能缓解产后断奶社会隔离诱导的注意力缺陷多动症大鼠模型攻击行为加剧的现象
Yu Nishimura,Dewi Mustika,Shinya Ueno et al.
Yu Nishimura et al.
We investigated whether monosodium aspartate (MSA), an umami compound structurally analogous to monosodium glutamate (MSG), influences aggressive behavior in a rat model of attention-deficit/hyperactivity disorder. Spontaneously hypertensiv...
The coiled-coil domain of myosin-11 as a potential biomarker to detect patients with atherosclerotic cardiovascular disease risk [0.03%]
肌球蛋白-11的卷曲螺旋结构域可作为动脉粥样硬化性心血管疾病风险患者的潜在生物标志物
Lisa Takahashi,Hirofumi Tomiyama,Hiroki Kobori et al.
Lisa Takahashi et al.
Atherosclerosis leads to severe clinical complications, and biomarkers for asymptomatic atherosclerosis are desired. Plasma levels of myosin-11 have been reported to increase in patients with symptomatic atherosclerosis. To investigate the ...