LAMC1 aggravates diabetic retinopathy through PI3K/AKT signaling-regulated epithelial-mesenchymal transition in retinal pigment epithelial cells [0.03%]
LAMC1通过PI3K/AKT信号调节的上皮间质转化加重糖尿病性视网膜病变
Lei Liu,Yanlin Gao,Shiqi Yao
Lei Liu
Diabetic retinopathy (DR), a leading cause of adult blindness, with LAMC1-mediated epithelial-mesenchymal transition (EMT) playing a key role. By analyzing DR-related microarray datasets (GSE60436/GSE102485) from GEO, we identified 685 diff...
Estradiol enhances thermoregulation induced by ostruthin, a TREK channel agonist, in ovariectomized rats [0.03%]
雌二醇增强卵巢切除大鼠由Ostruthin诱导的热调节作用
Yuki Uchida,Shotaro Kamijo,Yuki Samejima et al.
Yuki Uchida et al.
Menopausal women frequently report contradictory thermoregulatory symptoms (hot flashes and chills), believed to result from declining estradiol (E₂) levels; however, mechanisms remain unclear. TWIK-related (TREK) potassium channels functi...
Incompleteness of the circle of Willis affects sleep quality, cognitive function and inflammation in patients with primary hypertension [0.03%]
圈套不完整的患者原发性高血压影响睡眠质量，认知功能和炎症
Ying Feng,Xueqi Yang,Yang Song et al.
Ying Feng et al.
To investigate whether incomplete Circle of Willis (Incomplete CoW) affects neuropsychological outcomes in patients with primary hypertension, a cross-sectional study was conducted involving 150 patients diagnosed with primary hypertension,...
ATF4 transcriptionally activates NUPR1 to promote ferroptosis in chondrocytes and osteoarthritis development [0.03%]
转录因子ATF4通过激活NUPR1促进软骨细胞铁死亡及骨关节炎发生发展
Chen Kuang,Taiyang Liao,Lishi Jie et al.
Chen Kuang et al.
Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage destruction and inflammation. This study reveals that activating transcription factor 4 (ATF4) is upregulated in IL-1β-treated chondrocytes and promotes ...
Podoplanin hetero-insufficiency mice with inflammation in the jejunum demonstrates a good animal model of congenital protein-losing enteropathy [0.03%]
podoplanin杂合子不足小鼠结肠炎是获得性小肠蛋白丢失性肠病的良好动物模型
Toshio Ohhashi,Nagaharu Tsukiji,Moyuru Hayashi et al.
Toshio Ohhashi et al.
We have identified the Podoplanin expression in rat jejunal villi. We aimed to investigate the relationship between the Podoplanin expression in jejunal villi and the pathogenesis of congenital protein-losing enteropathy (PLE), using the Po...
Xanthine oxidase inhibitor allopurinol preserves cardiac function after experimental malocclusion induced by occlusal disharmony in mice [0.03%]
次黄嘌呤氧化酶抑制剂对小鼠咬合不调诱导的实验性错牙合所致心脏功能损伤的保护作用ALKOHOLIZM W PERSPEKTYWIE BIOLOGICZNEJ ORAZ SOCJO-KULTUROWEJ
Takao Mitsubayashi,Kenji Suita,Yoshiki Ohnuki et al.
Takao Mitsubayashi et al.
Oxidative stress caused by poor oral condition is associated with systemic diseases, including cardiovascular disease. In this work, therefore, we examined the effect of allopurinol, an inhibitor of the reactive oxygen species (ROS)-produci...
Fumiya Kurihara,Wendy Hempstock,Noriko Ishizuka et al.
Fumiya Kurihara et al.
Aging is understood to be a time-dependent decline in various physiological functions. Motor and sensory functions deteriorate relatively early after maturity, while nutrient absorption and barrier functions in the digestive tract are repor...
Differences in the autonomic regulation of temperature in the lower lip and tongue during activation of the lingual nerve [0.03%]
舌神经激活时下唇和舌尖的自主调节差异
Syed Taufiqul Islam,Toshiya Sato,Hanako Ohke et al.
Syed Taufiqul Islam et al.
Orofacial temperature influences orofacial functions and is related to hemodynamics mediated by the autonomic nerves. Although the properties of autonomic vasomotor responses differ in orofacial tissues, differences in the autonomic regulat...
Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1 [0.03%]
转化生长因子-β1表达降低的小鼠主动脉囊肿模型的研究
Masao Kakoki,John R Hagaman,Masahiko Terajima et al.
Masao Kakoki et al.
In humans, loss-of-function mutations in multiple component genes of transforming growth factor (TGF)-β signaling have been demonstrated to cause proximal aortic aneurysms. However, association of human variants in the prototype ligand TGF...
Pupil dilation evoked by painful electrical stimulation is abolished during pain inhibition by distraction [0.03%]
注意力分散引起的疼痛抑制会消除电刺激诱发的瞳孔散大现象
Alice Wagenaar-Tison,Zoha Deldar,Antoine Bergeron et al.
Alice Wagenaar-Tison et al.
The aim of the present study was to examine the contribution of spinal and supraspinal processes to pain modulation by attention. It is hypothesized that pain inhibition by distraction is accompanied by reduced pain-evoked pupil dilation an...