Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes [0.03%]
肥胖及不同体重代谢表型受试者血清维生素D浓度与Thpoissonin-1/Toll样受体4(TSP1/TLR4)信号通路关系的研究
Eman Y Khairy,Azza Saad
Eman Y Khairy
Thrombospondin-1 (TSP1) contributes to obesity-associated inflammation via activating Toll-like receptor 4 (TLR4). The regulatory role of vitamin D on this pathway has been suggested. This study aimed to investigate the relationship between...
Febuxostat ameliorates muscle degeneration and movement disorder of the dystrophin mutant model in Caenorhabditis elegans [0.03%]
富马斯他改善了秀丽隐杆线虫肌营养不良突变模型的肌肉退化和运动障碍症状
Sawako Yoshina,Luna Izuhara,Rei Mashima et al.
Sawako Yoshina et al.
Duchenne muscular dystrophy (DMD) is an inherited disorder with mutations in the dystrophin gene characterized by progressive muscle degeneration and weakness. Therapy such as administration of glucocorticoids, exon skipping of mutant genes...
Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery-Dreifuss muscular dystrophy caused by an LMNA gene mutation [0.03%]
emerin缺乏不会加重LMNA基因突变引起的Emery-Dreifuss肌营养不良症小鼠模型的心肌病
Eiji Wada,Kohei Matsumoto,Nao Susumu et al.
Eiji Wada et al.
Emery-Dreifuss muscular dystrophy (EDMD), caused by mutations in genes encoding nuclear envelope proteins, is clinically characterized by muscular dystrophy, early joint contracture, and life-threatening cardiac abnormalities. To elucidate ...
Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review [0.03%]
评估热适应表型的分子生物标志物：叙述性综述
J Corbett,J S Young,M J Tipton et al.
J Corbett et al.
Heat acclimation/acclimatisation (HA) mitigates heat-related decrements in physical capacity and heat-illness risk and is a widely advocated countermeasure for individuals operating in hot environments. The efficacy of HA is typically quant...
Yusuke Otani,Soichiro Yoshikawa,Kei Nagao et al.
Yusuke Otani et al.
Mast cells are present in mucosal and connective tissues throughout the body. They synthesize and release a wide variety of bioactive molecules, such as histamine, proteases, and cytokines. In this study, we found that a population of conne...
Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study [0.03%]
人脑氧摄取分数不均匀：正电子发射断层扫描研究
Hiroshi Ito,Masanobu Ibaraki,Ryo Yamakuni et al.
Hiroshi Ito et al.
The regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement estimated by simulation studies. Th...
Involvement of cannabinoid receptors in depression of the putative nociceptive response in spinal cord preparations isolated from neonatal rats [0.03%]
大鼠脊髓离体切片中 cannabinoid 受体与伤害性反应的抑制有关
Kayo Tsuzawa,Hiroshi Onimaru,Katsunori Inagaki et al.
Kayo Tsuzawa et al.
A metabolite of acetaminophen, AM404, which is an anandamide transporter inhibitor, induces analgesia mainly via activation of transient receptor potential channel 1 in the spinal cord, although the role of cannabinoid receptors remains to ...
A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case-control study [0.03%]
妊娠糖尿病发病风险与血清CCN5/WISP2水平正相关：一项病例对照研究
Mohammed Farhan Hamdan Alshganbee,Fariba Nabatchian,Vida Farrokhi et al.
Mohammed Farhan Hamdan Alshganbee et al.
Introduction: CCN5/WISP2 is prominently manifest in adipose tissue and has been linked to the pathogenesis of obesity, diabetes, and insulin resistance. However, discrepancies exist in previous studies, and little is know...
Masanari Umemura,Rina Nakakaji,Yoshihiro Ishikawa
Masanari Umemura
Intracellular calcium (Ca2+) signaling regulates many cellular functions, including cell proliferation and migration, in both normal cells and cancer cells. Store-operated Ca2+ entry (SOCE) is a major mechanism by which Ca2+ is imported fro...
Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size [0.03%]
转化增殖细胞的耗竭不影响静息状态下的神经干细胞池大小
Zakiyyah Munirah Mohd Zaki,Anri Kuroda,Naoko Morimura et al.
Zakiyyah Munirah Mohd Zaki et al.
Neural stem cells (NSCs) are maintained in the adult mammalian brain throughout the animal's lifespan. NSCs in the subependymal zone infrequently divide and generate transit amplifying cells, which are destined to become olfactory bulb neur...