Weight loss by sodium-glucose co-transporter 2 inhibitor canagliflozin is followed by rebound in db/db mice but maintained in fat-fed mice via circadian rises in body temperature and locomotor activity [0.03%]
钠-葡萄糖共转运蛋白2抑制剂卡格列净诱导的减重在db/db小鼠中会出现反弹，但在高脂喂养的小鼠中可通过昼夜节律体温升高和运动增加维持下来
Lei Wang,Wanxin Han,Dauren Zhantleu et al.
Lei Wang et al.
Sodium-glucose co-transporter 2 (SGLT2) inhibitors, diabetic medicines, induce glucosuria to lower glycemia and energy reserve, initially reducing weight. The weight-reducing capacity substantially differs between individuals, likely due to...
Involvement of interaction between TRPM2 and IKCA1 in temperature-dependent movement and IL-1β production in mouse microglia [0.03%]
TRPM2与IKCA1相互作用在小胶质细胞温度依赖性运动和IL-1β生成中的参与作用
Aykut Deveci,Makiko Kashio,Sandra Derouiche et al.
Aykut Deveci et al.
Transient potential melastatin 2 (TRPM2) plays important roles in Ca2 + signaling in tissues and cells, and contributes to various cellular functions. The Ca2+ influx induced by TRPM2 may activate the intermediate conductance Ca2+-activated...
Toward the promotion of One Health - Part II: Interdisciplinary research cooperation between digital transformation and exposome [0.03%]
迈向健康一体·第二部分：数字化转型与暴露组的跨学科研究合作
Takeshi Yoneshiro,Yoshito Kumagai,Keiko Nohara et al.
Takeshi Yoneshiro et al.
Human activities increasingly disrupt global ecosystems, contributing to climate change, biodiversity loss, and emerging health threats. In response, the One Health framework has gained attention as an integrative approach encompassing huma...
Middle-aged mice show delayed and destabilized food-anticipatory circadian activity under restricted feeding [0.03%]
限食饲养的中年小鼠表现出延迟和不稳定的预期摄食行为昼夜节律性活动
Sachi N Ohno,Nana N Takasu,Hitoshi Uchida et al.
Sachi N Ohno et al.
Mice are nocturnal and normally feed during the night; however, timed daily feeding can markedly alter behavioral and physiological rhythms. A well-known example is food-anticipatory activity (FAA), characterized by increased locomotor acti...
Physiological doses of eicosapentaenoic acid suppress high-fat diet-induced atrial fibrillation in mice independent of lipid lowering [0.03%]
生理剂量的二十碳五烯酸通过降低脂质水平以外的机制抑制高脂肪饮食诱导的小鼠房颤
Kosuke Horii,Katsushige Ono,Seiji Masuda et al.
Kosuke Horii et al.
Long-term treatment with eicosapentaenoic acid (EPA) has been reported to reduce the risk of atrial fibrillation (AF) in mice fed a high-fat diet (HFD); however, the appropriate dose required to attenuate atrial vulnerability to AF remains ...
Changqi Shi,Ziyi Chen,LuLu Zhang et al.
Changqi Shi et al.
Sweat is a complex biological fluid primarily responsible for thermoregulation, containing diverse organic and inorganic components derived from plasma and interstitial fluids. Its secretion is tightly regulated by hypothalamic-sympathetic ...
Yang Yu,John Curry,Sarah Tankersley et al.
Yang Yu et al.
TASK-1 channel is important for regulating membrane potential. However, its response to pathological conditions remains unknown. In this study, we investigated the effects of hypoxia on the recombinant TASK-1 channel localization at the sur...
Genetic inactivation of TRPM4 does not alter the temperature-dependent movement of mouse microglia [0.03%]
遗传失活TRPM4不影响小胶质细胞的温度依赖性运动
Rei Nishimoto,Yoshikazu Matsuoka,Makoto Tominaga
Rei Nishimoto
Temperature sensing shapes behavior and cellular functions, yet the molecular basis of thermosensitivity in non-neuronal cells remains poorly defined. Microglia are resident immune cells of the central nervous system that help maintain brai...
Non-nutritive sweeteners attenuate reinforced cephalic phase insulin release and impair glucose tolerance in mice [0.03%]
非营养性甜味剂会减弱小鼠条件化头期胰岛素反应并损害葡萄糖耐量
Tomonari Otsuki,Keiji Okihara,Kengo Nomura et al.
Tomonari Otsuki et al.
Non-nutritive artificial sweeteners (NNSs) which provide sweetness with minimal calories are used to reduce sugar consumption, while orosensory stimuli such as sweet taste can stimulate insulin secretion known as cephalic phase insulin rele...
Effects of systemic ventricular assist combined with fenestration in failing Fontan: A theoretical analysis [0.03%]
Fontan手术失败时全身心室辅助联合开窗的疗效：理论分析
Shuji Shimizu,Yasuhiro Kotani,Naohiro Horio et al.
Shuji Shimizu et al.
Biventricular assist for failing Fontan circulation remains challenging. Because fenestration effectively reduces stressed blood volume and central venous pressure in Fontan patients with increased pulmonary vascular resistance (PVR), syste...