Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2 [0.03%]
加热不燃烧烟草产品烟气提取物对人类口腔鳞状细胞癌的细胞毒性作用：活性氧和CaMKK2的作用
Nagao Kagemichi,Masanari Umemura,Soichiro Ishikawa et al.
Nagao Kagemichi et al.
Background: The increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous studies have demonstrated the toxicity of cigarette smoke extract (CSE) from...
Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC: part 2: its activation mechanisms and essential roles in organic signal release [0.03%]
容积敏感/调节性阴离子通道VSOR/VRAC的生理功能（二）：其激活机制及其在有机信号释放中的重要作用
Yasunobu Okada
Yasunobu Okada
The volume-sensitive outwardly rectifying or volume-regulated anion channel, VSOR/VRAC, which was discovered in 1988, is expressed in most vertebrate cell types, and is essentially involved in cell volume regulation after swelling and in th...
Identification of hypothermia-inducing neurons in the preoptic area and activation of them by isoflurane anesthesia and central injection of adenosine [0.03%]
视前区诱导低体温神经元的鉴定及其在吸入异氟醚麻醉和中枢注射腺苷时被激活
Erika Uchino,Ikue Kusumoto-Yoshida,Hideki Kashiwadani et al.
Erika Uchino et al.
Hibernation and torpor are not passive responses caused by external temperature drops and fasting but are active brain functions that lower body temperature. A population of neurons in the preoptic area was recently identified as such activ...
Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver [0.03%]
运动限制卡路里的耐力锻炼对小鼠骨骼肌和肝脏能量底物代谢的影响
Kenya Takahashi,Yu Kitaoka,Hideo Hatta
Kenya Takahashi
We investigated whether calorie restriction (CR) enhances metabolic adaptations to endurance training (ET). Ten-week-old male Institute of Cancer Research (ICR) mice were fed ad libitum or subjected to 30% CR. The mice were subdivided into ...
US-Japan NVU Workshop Group
US-Japan NVU Workshop Group
The joint workshop between U.S. and Japanese researchers, supported by The U.S.-Japan Brain Research Cooperative Program, convened in January 2023 at Keio University Mita campus in Tokyo, Japan. The workshop had a threefold objective. First...
Yutaro Oguma,Toshi Nakajima,Megan Elizabeth Young et al.
Yutaro Oguma et al.
Experiments measuring evoked potentials require flexible and rapid adjustment of stimulation and recording parameters. In this study, we have developed a recording system and an associated Android application that allow making such adjustme...
The evidence to date: implications of l-ascorbic acid in the pathophysiology of aging [0.03%]
迄今为止的证据：L-抗坏血酸在衰老病理生理学中的意义
Ayami Sato,Yoshitaka Kondo,Akihito Ishigami
Ayami Sato
L-Ascorbic acid, commonly known as vitamin C, has been used not only for disease prevention and in complementary and alternative medicine, but also for anti-aging purposes. However, the scientific evidence is not yet sufficient. Here, we re...
Taiga Ishimoto,Hideyuki Kosumi,Ken Natsuga et al.
Taiga Ishimoto et al.
Growth and differentiation are reduced or stopped during hibernation, an energy conserving strategy in harsh seasons by lowered metabolism and body temperature. However, few studies evaluated this in a same individual using a non-invasive m...
Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats [0.03%]
嘌呤通过P2Y受体和ATP依赖的钾通道调节大鼠食管平滑肌的抑制功能
Takahiko Shiina,Yuji Suzuki,Kazuhiro Horii et al.
Takahiko Shiina et al.
Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was...
Two synergistic types of muscles were detected during forearm rotation exercise by T2 cumulative frequency curves using 0.2 T magnetic resonance imaging [0.03%]
低场磁共振T2累计频率曲线在前臂旋转运动中检测两种协同工作的肌肉类型
Masayoshi Takamori,Sumikazu Akiyama,Yoshiteru Seo et al.
Masayoshi Takamori et al.
The purpose of this study was the detection and characterization of synergistic muscle activity. Using T2-map MRI, T2 values for 10 forearm muscles in 11 healthy adult volunteers were obtained in the resting state and after isotonic forearm...