Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver [0.03%]
运动限制卡路里的耐力锻炼对小鼠骨骼肌和肝脏能量底物代谢的影响
Kenya Takahashi,Yu Kitaoka,Hideo Hatta
Kenya Takahashi
We investigated whether calorie restriction (CR) enhances metabolic adaptations to endurance training (ET). Ten-week-old male Institute of Cancer Research (ICR) mice were fed ad libitum or subjected to 30% CR. The mice were subdivided into ...
US-Japan NVU Workshop Group
US-Japan NVU Workshop Group
The joint workshop between U.S. and Japanese researchers, supported by The U.S.-Japan Brain Research Cooperative Program, convened in January 2023 at Keio University Mita campus in Tokyo, Japan. The workshop had a threefold objective. First...
Yutaro Oguma,Toshi Nakajima,Megan Elizabeth Young et al.
Yutaro Oguma et al.
Experiments measuring evoked potentials require flexible and rapid adjustment of stimulation and recording parameters. In this study, we have developed a recording system and an associated Android application that allow making such adjustme...
The evidence to date: implications of l-ascorbic acid in the pathophysiology of aging [0.03%]
迄今为止的证据：L-抗坏血酸在衰老病理生理学中的意义
Ayami Sato,Yoshitaka Kondo,Akihito Ishigami
Ayami Sato
L-Ascorbic acid, commonly known as vitamin C, has been used not only for disease prevention and in complementary and alternative medicine, but also for anti-aging purposes. However, the scientific evidence is not yet sufficient. Here, we re...
Taiga Ishimoto,Hideyuki Kosumi,Ken Natsuga et al.
Taiga Ishimoto et al.
Growth and differentiation are reduced or stopped during hibernation, an energy conserving strategy in harsh seasons by lowered metabolism and body temperature. However, few studies evaluated this in a same individual using a non-invasive m...
Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats [0.03%]
嘌呤通过P2Y受体和ATP依赖的钾通道调节大鼠食管平滑肌的抑制功能
Takahiko Shiina,Yuji Suzuki,Kazuhiro Horii et al.
Takahiko Shiina et al.
Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was...
Two synergistic types of muscles were detected during forearm rotation exercise by T2 cumulative frequency curves using 0.2 T magnetic resonance imaging [0.03%]
低场磁共振T2累计频率曲线在前臂旋转运动中检测两种协同工作的肌肉类型
Masayoshi Takamori,Sumikazu Akiyama,Yoshiteru Seo et al.
Masayoshi Takamori et al.
The purpose of this study was the detection and characterization of synergistic muscle activity. Using T2-map MRI, T2 values for 10 forearm muscles in 11 healthy adult volunteers were obtained in the resting state and after isotonic forearm...
Effects of cytochalasin D on relaxation process of skinned taenia cecum and carotid artery from guinea pig [0.03%]
Calphostin C和Cytochalasin D对麻醉豚鼠盲肠条和平动脉去膜肌条松弛过程的影响研究
Satoko Mihashi,Masaru Watanabe
Satoko Mihashi
Actin linked regulatory mechanisms are known to contribute contraction/relaxation in smooth muscle. In order to clarify whether modulation of polymerization/depolymerization of actin filaments affects relaxation process, we examined the eff...
Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2 [0.03%]
乙酸通过改善线粒体融合蛋白2治疗来瑞昔芬诱导的多囊卵巢综合征小鼠模型中的卵巢线粒体功能障碍
Kehinde S Olaniyi,Stephanie E Areloegbe
Kehinde S Olaniyi
Androgen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates ovarian dysfunction and infertility in reproductive-age women. Impaired mitochondrial funct...
Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect [0.03%]
甲状腺腺瘤相关蛋白（THADA）在强心苷诱导的抗癌效应中的负向调节作用
Mizuki Katoh,Takuto Fujii,Yoshiaki Tabuchi et al.
Mizuki Katoh et al.
Cardiac glycosides, known as inhibitors of Na+,K+-ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of cancer cell death. Here, we examined the signaling pathway elicited by cardiac glycosides i...