TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity [0.03%]
TRPV2：一种具有尚未明确的温度敏感性的细胞生理普遍调节因子
Tabea C Fricke,Andreas Leffler
Tabea C Fricke
Transient receptor potential (TRP) ion channels serve as sensors for variations in ambient temperature, modulating both thermoregulation and temperature responsive cellular processes. Among these, the vanilloid TRP subfamily (TRPV) comprise...
Age-related histone H3.3 accumulation associates with a repressive chromatin in mouse tibialis anterior muscle [0.03%]
与小鼠胫前肌染色抑制相关的年龄相关组蛋白H3.3积累
Ryo Masuzawa,Hemilce Karina Rosa Flete,Junya Shimizu et al.
Ryo Masuzawa et al.
The present study aimed to investigate age-related changes in histone variant H3.3 and its role in the aging process of mouse tibialis anterior muscle. H3.3 level significantly increased with age and correlated with H3K27me3 level. Acute ex...
Role of the central nervous system in cell non-autonomous signaling mechanisms of aging and longevity in mammals [0.03%]
中枢神经系统在哺乳动物衰老和长寿的细胞非自主信号机制中的作用
Takuya Urushihata,Akiko Satoh
Takuya Urushihata
Multiple organs orchestrate the maintenance of proper physiological function in organisms throughout their lifetimes. Recent studies have uncovered that aging and longevity are regulated by cell non-autonomous signaling mechanisms in severa...
The influence of exercise intensity on comorbid anxious behavior in psychiatric conditions [0.03%]
运动强度对精神疾病共病焦虑行为的影响
Dong-Joo Hwang,Tae-Kyung Kim
Dong-Joo Hwang
Many experts have extensively studied the potential of exercise as a treatment option for psychiatric conditions, including depression and autism spectrum disorder (ASD). Despite their core symptoms, these conditions exhibits comparable com...
Age-related alteration of the involvement of CD36 for salivary secretion from the parotid gland in mice [0.03%]
小鼠年龄相关的调节CD36参与腮腺分泌作用的变化
Keitaro Satoh,Yuta Ohno,Haruna Nagase et al.
Keitaro Satoh et al.
This in vivo mouse model study was conducted to investigate the temporal alteration of the function of CD36 in salivary secretion. CD36 was highly expressed in the parotid gland of BALB/c mice. No significant variations were shown in the CD...
Microglia mediate the increase in slow-wave sleep associated with high ambient temperature [0.03%]
小胶质细胞介导环境高温诱发的慢波睡眠增加现象
Sena Hatori,Futaba Matsui,Zhiwen Zhou et al.
Sena Hatori et al.
An increase in ambient temperature leads to an increase in sleep. However, the mechanisms behind this phenomenon remain unknown. This study aimed to investigate the role of microglia in the increase of sleep caused by high ambient temperatu...
The interactive effects of different exercises and hawthorn consumption on the pain threshold of TMT-induced Alzheimer male rats [0.03%]
不同运动和山楂摄入对TMT致病阿尔兹海默症雄性大鼠痛阈的交互作用研究
Ensiyeh Almasi,Ali Heidarianpour,Maryam Keshvari
Ensiyeh Almasi
Exercise increases the pain threshold in healthy people. However, the pain threshold modulation effect of exercise and hawthorn is unclear because of its potential benefits in people with persistent pain, including those with Alzheimer's di...
Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2 [0.03%]
加热不燃烧烟草产品烟气提取物对人类口腔鳞状细胞癌的细胞毒性作用：活性氧和CaMKK2的作用
Nagao Kagemichi,Masanari Umemura,Soichiro Ishikawa et al.
Nagao Kagemichi et al.
Background: The increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous studies have demonstrated the toxicity of cigarette smoke extract (CSE) from...
Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC: part 2: its activation mechanisms and essential roles in organic signal release [0.03%]
容积敏感/调节性阴离子通道VSOR/VRAC的生理功能（二）：其激活机制及其在有机信号释放中的重要作用
Yasunobu Okada
Yasunobu Okada
The volume-sensitive outwardly rectifying or volume-regulated anion channel, VSOR/VRAC, which was discovered in 1988, is expressed in most vertebrate cell types, and is essentially involved in cell volume regulation after swelling and in th...
Identification of hypothermia-inducing neurons in the preoptic area and activation of them by isoflurane anesthesia and central injection of adenosine [0.03%]
视前区诱导低体温神经元的鉴定及其在吸入异氟醚麻醉和中枢注射腺苷时被激活
Erika Uchino,Ikue Kusumoto-Yoshida,Hideki Kashiwadani et al.
Erika Uchino et al.
Hibernation and torpor are not passive responses caused by external temperature drops and fasting but are active brain functions that lower body temperature. A population of neurons in the preoptic area was recently identified as such activ...