ADAM8 promotes alcoholic liver fibrosis through the MAPK signaling pathway [0.03%]
ADAM8通过MAPK信号通路促进酒精性肝纤维化
Mengli Yang,Sanqiang Li,Renli Luo et al.
Mengli Yang et al.
The effect and molecular regulatory mechanism of A Disintegrin and Metalloproteinase 8 (ADAM8) were explored in alcoholic liver fibrosis (ALF). C57BL/6N male mice were randomly divided into control, alcohol, and ADAM8-sgRNA3 plasmid groups....
Advanced glycation end products promote ROS production via PKC/p47 phox axis in skeletal muscle cells [0.03%]
晚期糖基化终末产物通过PKC/p47(phox)轴促进骨骼肌细胞ROS生成
Shinichiro Suzuki,Tatsuya Hayashi,Tatsuro Egawa
Shinichiro Suzuki
Advanced glycation end products (AGEs) are risk factors for various diseases, including sarcopenia. One of the deleterious effects of AGEs is the induction of abnormal reactive oxygen species (ROS) production in skeletal muscle. However, th...
Acupuncture improves spatial learning and memory impairment caused by herpes simplex virus type-1 in rats through the p38 MAPK/CREB pathway [0.03%]
针刺通过p38MAPK/CREB信号通路改善HSV-1致大鼠空间学习记忆障碍作用的研究
Hongjiao Jin,Rui Huang,Zhu Li et al.
Hongjiao Jin et al.
Background: Acupuncture can improve herpes simplex encephalitis (HSE), but the underlying mechanism is not clear. Therefore, we evaluated the cognitive function and apoptosis in hippocampus caused by herpes simplex virus ...
Thermosensing ability of TRPC5: current knowledge and unsettled questions [0.03%]
TRPC5热感受能力：已有认识和未决问题
Alexandra Ptakova,Viktorie Vlachova
Alexandra Ptakova
Our understanding of how the mammalian somatosensory system detects noxious cold is still limited. While the role of TRPM8 in signaling mild non-noxious coolness is reasonably understood, the molecular identity of channels transducing painf...
Acute effects of empagliflozin on open-loop baroreflex function and urine output in streptozotocin-induced type 1 diabetic rats [0.03%]
恩格列净对链脲佐菌素诱导的1型糖尿病大鼠血压反向调节功能及尿量的急性影响
Toru Kawada,Hiromi Yamamoto,Masafumi Fukumitsu et al.
Toru Kawada et al.
Although sympathetic suppression is considered one of the mechanisms for cardioprotection afforded by sodium-glucose cotransporter 2 (SGLT2) inhibitors, whether SGLT2 inhibition acutely modifies sympathetic arterial pressure (AP) regulation...
Anekomochi glutinous rice provides low postprandial glycemic response by enhanced insulin action via GLP-1 release and vagal afferents activation [0.03%]
淀粉大米通过GLP-1释放和迷走传入神经激活增强胰岛素作用提供低餐后血糖反应
Kento Ohbayashi,Yudai Sugiyama,Taichi Nohmi et al.
Kento Ohbayashi et al.
Glutinous rice (mochi rice), compared to non-glutinous rice (uruchi rice), exhibits a wide range of glycemic index (GI) values, from low to high. However, the underlying mechanisms behind the variation in GI values remain poorly understood....
Limitations and potential strategies of immune checkpoint blockade in age-related neurodegenerative disorders [0.03%]
免疫检查点抑制剂在年龄相关神经退行性疾病中的局限性及潜在策略
Noha N Lasheen,Salma Allam,Abdullrahman Elgarawany et al.
Noha N Lasheen et al.
Neurological disorders such as Alzheimer's disease (AD), and Parkinson's disease (PD) have no disease-modifying treatments, resulting in a global dementia crisis that affects more than 50 million people. Amyloid-beta (Aβ), tau, and alpha-s...
The involvement and significance of M2 macrophages in neuropathic pain following spinal cord injury: a systematic review [0.03%]
脊髓损伤后M2型小胶质细胞/巨噬细胞在神经病理性疼痛发生发展中的作用及意义：系统综述
Aidin Shahrezaei,Maryam Sohani,Mohammadhassan Sohouli et al.
Aidin Shahrezaei et al.
Neuropathic pain (NeP) is a type of persistent pain initiated by diseases or injuries of the nervous system. Although the underlying pathophysiological mechanisms of NeP are poorly understood, the immune system plays a key role in this cond...
Kunitoshi Uchida
Kunitoshi Uchida
Temperature detection is essential for the survival and perpetuation of any species. Thermoreceptors in the skin sense body temperature as well as the temperatures of ambient air and objects. Since Dr. David Julius and his colleagues discov...
Gravitational change-induced alteration of the vestibular function and gene expression in the vestibular ganglion of mice [0.03%]
重力变化诱发小鼠前庭功能和前庭神经节基因表达的改变
Murat Bazek,Motoya Sawa,Kazuhiro Horii et al.
Murat Bazek et al.
Gravity has profoundly influenced life on Earth, yet how organisms adapt to changes in gravity remains largely unknown. This study examines vestibular plasticity, specifically how the vestibular system responds to altered gravity. We subjec...