Jing Lei,Makoto Tominaga
Jing Lei
Human skin, as a sophisticated sensory organ, is able to detect subtle changes in ambient temperature. This thermosensory capability is primarily mediated by temperature-sensitive TRP channels expressed in both sensory neurons and keratinoc...
Sho Kakizawa
Sho Kakizawa
Reactive oxygen species (ROS) are redox-signaling molecules involved in aging and lifestyle-related diseases. In the brain, in addition to the production of ROS as byproducts of metabolism, expression of ROS synthases has recently been demo...
The interaction between orexin, sleep deprivation and Alzheimer's disease: Unveiling an Emerging Connection [0.03%]
食欲素、睡眠缺失与阿尔茨海默病之间的相互作用：揭示新兴联系
Masoumeh Kourosh-Arami,Mahdi Ramezani,Alireza Komaki
Masoumeh Kourosh-Arami
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Sleep-wake disorders are an extremely predominant and often disabling aspect of AD. Ox is vital in maintain...
Enhanced cardiac vagal activity and mood after low-dose hypoxic gas inhalation in healthy young adults [0.03%]
健康年轻人吸入低剂量缺氧气体后的增强心脏副交感神经活性和情绪变化
Dongmin Lee,Yudai Yamazaki,Ryuta Kuwamizu et al.
Dongmin Lee et al.
Developing strategies to enhance cardiac vagal activity (CVA) is essential for improving mood and managing stress. Although hypoxia inhalation may boost CVA, the optimal acute hypoxic conditions remain unclear. Therefore, we aimed to achiev...
Evaluation of the effects of fenestration in Fontan circulation using a lumped parameter model [0.03%]
应用集中参数模型评估Fontan术式中开窗的影响
Naohiro Horio,Shuji Shimizu,Yasuhiro Kotani et al.
Naohiro Horio et al.
Fenestration has been reported to enhance Fontan hemodynamics in several cases of Fontan circulation. However, the indication criteria for fenestration remain under discussion. To assess the effectiveness of fenestration in Fontan circulati...
The potential role of exercise in mitigating fertility toxicity associated with immune checkpoint inhibitors (ICIs) in cancer patients [0.03%]
运动在减轻与免疫检查点抑制剂（ICIs）相关的生育毒性的潜在作用
Parivash Jamrasi,Mia Tazi,Nur Afiqah Zulkifli et al.
Parivash Jamrasi et al.
Over the last decade, therapeutic advances in cancer immunotherapy have rapidly progressed, leading to an expansion of clinical trials and the development of novel immune checkpoint inhibitors (ICIs) and combination treatments. While ICIs o...
Correction: Age-related alteration of the involvement of CD36 for salivary secretion from the parotid gland in mice [0.03%]
订正：年龄相关的小鼠腮腺唾液分泌中CD36作用的变化
Keitaro Satoh,Yuta Ohno,Haruna Nagase et al.
Keitaro Satoh et al.
TRPV4 activation by core body temperature has multimodal functions in the central nervous system [0.03%]
核心体温激活的TRPV4在中枢神经系统中的多重功能
Koji Shibasaki
Koji Shibasaki
Brain temperature is strictly regulated by various endogenous mechanisms and significantly contributes to brain function in homeothermic animals, making it an important factor for health. Thermosensitive transient receptor potential (TRP) c...
Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats [0.03%]
激活腰骶排便中心的胃促生长素激动剂的性别二态性プロキネティック作用
Shumpei Tsukamoto,Tomoya Sawamura,Natsufu Yuki et al.
Shumpei Tsukamoto et al.
We investigated the effects of a centrally penetrant ghrelin agonist, RQ-00538053, on colorectal motility in female rats in comparison with that in male rats. Intravenous administration of RQ-00538053 enhanced colorectal motility in female ...
Effects of systemic ventricular assist in failing Fontan patients: a theoretical analysis using a computational model [0.03%]
计算模型在Fontan术后心室辅助下的理论分析及影响因素研究
Eiri Kisamori,Yasuhiro Kotani,Toshiaki Shishido et al.
Eiri Kisamori et al.
Mechanical circulatory support is a potential treatment for failing Fontan patients. In this study, we performed a theoretical analysis using a computational model to clarify the effects of systemic ventricular assist device (VAD) in failin...