The evidence to date: implications of l-ascorbic acid in the pathophysiology of aging [0.03%]
至今为止的证据：L-抗坏血酸在衰老病理生理学中的意义
Ayami Sato,Yoshitaka Kondo,Akihito Ishigami
Ayami Sato
L-Ascorbic acid, commonly known as vitamin C, has been used not only for disease prevention and in complementary and alternative medicine, but also for anti-aging purposes. However, the scientific evidence is not yet sufficient. Here, we re...
A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case-control study [0.03%]
妊娠糖尿病发病风险与血清CCN5/WISP2水平正相关：一项病例对照研究
Mohammed Farhan Hamdan Alshganbee,Fariba Nabatchian,Vida Farrokhi et al.
Mohammed Farhan Hamdan Alshganbee et al.
Introduction: CCN5/WISP2 is prominently manifest in adipose tissue and has been linked to the pathogenesis of obesity, diabetes, and insulin resistance. However, discrepancies exist in previous studies, and little is know...
Telocytes response to cardiac growth induced by resistance exercise training and endurance exercise training in adult male rats [0.03%]
阻力训练和耐力训练诱导的心肌生长对成年大鼠telocyte的影响
Siroos Choobineh,Mahboobeh Borjian Fard,Rahman Soori et al.
Siroos Choobineh et al.
Telocytes are interstitial cells found in different tissues, including cardiac stem cell niches. The purpose of this study was to investigate the response of the telocytes to the cardiac growth that occurs in response to resistance and endu...
Acute effects of empagliflozin on open-loop baroreflex function and urinary glucose excretion in rats with chronic myocardial infarction [0.03%]
恩格列净对慢性心肌梗死大鼠血压短时程调控功能及尿糖排泄的急性影响
Toru Kawada,Meihua Li,Akitsugu Nishiura et al.
Toru Kawada et al.
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have exerted cardioprotective effects in clinical trials, but underlying mechanisms are not fully understood. As mitigating sympathetic overactivity is of major clinical concern in the mecha...
Vidarabine, an anti-herpes agent, improves Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice [0.03%]
抗疱疹药物 vidarabine 改善牙龈卟啉单胞菌脂多糖诱导的小鼠心脏功能障碍
Michinori Tsunoda,Ichiro Matsuo,Yoshiki Ohnuki et al.
Michinori Tsunoda et al.
In this work, we examined the involvement of type 5 adenylyl cyclase (AC5) in cardiac dysfunction induced in mice given Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose equivalent to the circulating levels in periodontitis (PD...
Yoshinori Marunaka
Yoshinori Marunaka
Physiological roles of Cl-, a major anion in the body, are not well known compared with those of cations. This review article introduces: (1) roles of Cl- in bodily and cellular functions; (2) the range of cytosolic Cl- concentration ([Cl-]...
Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review [0.03%]
评估热习服表型的分子生物标志物：叙述性综述
J Corbett,J S Young,M J Tipton et al.
J Corbett et al.
Heat acclimation/acclimatisation (HA) mitigates heat-related decrements in physical capacity and heat-illness risk and is a widely advocated countermeasure for individuals operating in hot environments. The efficacy of HA is typically quant...
Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size [0.03%]
耗尽成人脑中的转运放大细胞不会影响静止的神经干细胞池大小
Zakiyyah Munirah Mohd Zaki,Anri Kuroda,Naoko Morimura et al.
Zakiyyah Munirah Mohd Zaki et al.
Neural stem cells (NSCs) are maintained in the adult mammalian brain throughout the animal's lifespan. NSCs in the subependymal zone infrequently divide and generate transit amplifying cells, which are destined to become olfactory bulb neur...
Yusuke Otani,Soichiro Yoshikawa,Kei Nagao et al.
Yusuke Otani et al.
Mast cells are present in mucosal and connective tissues throughout the body. They synthesize and release a wide variety of bioactive molecules, such as histamine, proteases, and cytokines. In this study, we found that a population of conne...
Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice [0.03%]
高脂饮食诱导的肥胖小鼠慢性自愿跑步运动通过PGC-1α表达改善代谢紊乱且独立于FNDC5/irisin通路
Chaeeun Cho,Minje Ji,Eunhee Cho et al.
Chaeeun Cho et al.
Exercise is an effective intervention to ameliorate metabolic diseases including obesity and insulin resistance, but the mechanisms involved in the metabolic amelioration have not yet been fully elucidated. This study aimed to determine whe...