Yusuke Otani,Soichiro Yoshikawa,Kei Nagao et al.
Yusuke Otani et al.
Mast cells are present in mucosal and connective tissues throughout the body. They synthesize and release a wide variety of bioactive molecules, such as histamine, proteases, and cytokines. In this study, we found that a population of conne...
Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice [0.03%]
高脂饮食诱导的肥胖小鼠慢性自愿跑步运动通过PGC-1α表达改善代谢紊乱且独立于FNDC5/irisin通路
Chaeeun Cho,Minje Ji,Eunhee Cho et al.
Chaeeun Cho et al.
Exercise is an effective intervention to ameliorate metabolic diseases including obesity and insulin resistance, but the mechanisms involved in the metabolic amelioration have not yet been fully elucidated. This study aimed to determine whe...
Activation of neurons in the insular cortex and lateral hypothalamus during food anticipatory period caused by food restriction in mice [0.03%]
限制喂食小鼠在限食anticipatory期引起岛叶皮层和下丘脑外侧区神经元的激活
Jihao Ma,Sakurako Yanase,Lisa Udagawa et al.
Jihao Ma et al.
Mice fed a single meal daily at a fixed time display food anticipatory activity (FAA). It has been reported that the insular cortex (IC) plays an essential role in food anticipation, and lateral hypothalamus (LH) regulates the expression of...
Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study [0.03%]
人脑氧摄取分数不均匀：正电子发射体层摄影研究结果显示
Hiroshi Ito,Masanobu Ibaraki,Ryo Yamakuni et al.
Hiroshi Ito et al.
The regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement estimated by simulation studies. Th...
Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice [0.03%]
口腔葡萄糖转运蛋白的糖信号诱发小鼠条件性胰岛素释放
Mitsuhito Takamori,Yoshihiro Mitoh,Kengo Horie et al.
Mitsuhito Takamori et al.
Cephalic-phase insulin release (CPIR) occurs before blood glucose increases after a meal. Although glucose is the most plausible cue to induce CPIR, peripheral sensory systems involved are not fully elucidated. We therefore examined roles o...
Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes [0.03%]
不同代谢表型肥胖者和正常体重者血清维生素D与ThpospNet/ Toll-like receptor 4(TSP1/TLR4)通路的关系研究
Eman Y Khairy,Azza Saad
Eman Y Khairy
Thrombospondin-1 (TSP1) contributes to obesity-associated inflammation via activating Toll-like receptor 4 (TLR4). The regulatory role of vitamin D on this pathway has been suggested. This study aimed to investigate the relationship between...
High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats [0.03%]
高强度间歇运动可减轻膝骨关节炎相关性痛觉过敏症状：对临床的潜在意义
Xinwei Wang,Jiulong Song,Peng Xia et al.
Xinwei Wang et al.
High-intensity interval training (HIIT) is a physical therapy that may benefit patients with osteoarthritis (OA). Cacna2d1 is a calcium channel subunit protein that plays an important role in the activity of nerve cells. However, there is c...
Effects of gentle mechanical skin stimulation on subjective symptoms and joint range of motions in people with chronic neck and shoulder discomfort [0.03%]
轻柔的机械皮肤刺激对慢性颈肩不适人群主观症状和关节活动度的影响
Nobuhiro Watanabe,Marina Nara,Shihoko Suzuki et al.
Nobuhiro Watanabe et al.
This study aimed to examine the efficacy of a 2-week self-administered gentle mechanical skin stimulation on chronic neck and shoulder discomfort. In participants (n = 12) with chronic neck and shoulder discomfort, subjective measures of pa...
Dogs showed lower parasympathetic activity during mutual gazing while owners did not [0.03%]
在对视中狗的副交感神经活动降低而主人未出现该情况
Miho Nagasawa,Maaya Saito,Haruka Hirasawa et al.
Miho Nagasawa et al.
The affiliative relationship between humans and dogs is compared to a mother-infant attachment relationship. We hypothesized that dog's attachment behavior in negative emotional state aroused the owner's attention toward the dog, that is, r...
Preoptic and hypothalamic regulation of multi-tiered, chronologically arranged female rat sexual behavior [0.03%]
下视丘前核和下视丘调节多级排列的雌鼠性行为
Yasuo Sakuma
Yasuo Sakuma
As in many mammalian behaviors, sexual behavior exhibits structure. Each modular components of the structure, that are linked together over time, occur in probabilistic manner. Endocrine milieu, in particular sex hormones, define the probab...