Non-nutritive sweeteners attenuate reinforced cephalic phase insulin release and impair glucose tolerance in mice [0.03%]
非营养性甜味剂会减弱小鼠条件化头期胰岛素反应并损害葡萄糖耐量
Tomonari Otsuki,Keiji Okihara,Kengo Nomura et al.
Tomonari Otsuki et al.
Non-nutritive artificial sweeteners (NNSs) which provide sweetness with minimal calories are used to reduce sugar consumption, while orosensory stimuli such as sweet taste can stimulate insulin secretion known as cephalic phase insulin rele...
Effects of systemic ventricular assist combined with fenestration in failing Fontan: A theoretical analysis [0.03%]
Fontan手术失败时全身心室辅助联合开窗的疗效：理论分析
Shuji Shimizu,Yasuhiro Kotani,Naohiro Horio et al.
Shuji Shimizu et al.
Biventricular assist for failing Fontan circulation remains challenging. Because fenestration effectively reduces stressed blood volume and central venous pressure in Fontan patients with increased pulmonary vascular resistance (PVR), syste...
Orai1- and STIM1-mediated calcium signaling controls PD-L1 expression and modulates antitumor immunity in oral cancer [0.03%]
口腔癌中ORAI1和STIM1介导的钙离子信号调控PD-L1表达并调节抗肿瘤免疫应答
Eriko Yamashita,Soichiro Ishikawa,Yuto Mizuno et al.
Eriko Yamashita et al.
This study investigated the regulation of PD-L1 expression by calcium signaling in oral squamous cell carcinoma (OSCC). We found that IFN-γ stimulation markedly altered the intracellular proteome and activated calcium-associated pathways. ...
Identification of a small molecule that targets activator of G-protein signaling 8 [0.03%]
一种靶向G蛋白信号激活因子8的小分子的鉴定
Alamgir Hossain,Aya Yamamura,Rie Takahashi et al.
Alamgir Hossain et al.
Activator of G-protein signaling 8 (AGS8), also known as fibronectin type III domain containing 1 (FNDC1), is an accessory protein for heterotrimeric G-proteins involved in various cellular processes. The interaction between AGS8 and Gβγ ...
Circadian feeding promotion by Ninjin'yoeito counteracts frailty in aged mice [0.03%]
ninjin-yoeito的昼夜促进食作用可抵抗小鼠衰老引起的衰弱症状
Lei Wang,Yermek Rakhat,Masanori Nakata et al.
Lei Wang et al.
Frailty in aging is a major health challenge, requiring solution. Older people with frailty often exhibit malnutrition and dysregulated feeding. Feeding behavior displays circadian rhythm, while aging and frailty involve rhythm disorders, s...
SIRT3-dependent enhancement of apelinergic signaling mediates the cardioprotective effects of late-life high-intensity interval training [0.03%]
长寿期高强度间歇训练的心脏保护作用依赖于Sirtuin 3介导的apelin信号通路增强效应
Qiaowei Li,Yanmei Song,Qin Liu et al.
Qiaowei Li et al.
Background: Deficiency in apelinergic signaling (APJ/Apelin) has been shown to accelerate cardiac aging. Given our observation that high-intensity interval training (HIIT) upregulates APJ and Apelin in aged mouse hearts, ...
Eric Mulder,Isak Löfquist,Felix Schagatay et al.
Eric Mulder et al.
Blackout (BO) in breath-hold diving is attributed to cerebral hypoxia, yet direct observations are rare. We continuously recorded arterial oxygen saturation (SpO₂) and heart rate (HR) in 11 trained freedivers (5 females) performing two dyn...
Effects of local skeletal muscle cooling prior to acute exercise and endurance training on mitochondrial adaptation in mice [0.03%]
局部肌肉冷却对小鼠急性运动和耐力训练诱导的线粒体适应的影响
Ryotaro Kano,Tatsuya Kusano,Taichi Ando et al.
Ryotaro Kano et al.
While post-exercise cooling is known to enhance skeletal muscle adaptations, the effects of pre-exercise cooling remain unclear. This study investigated whether local muscle cooling immediately before exercise augments training-induced mito...
Modulation of the association between blood glucose homeostasis and social hierarchy among co-housed mice by diet and amygdala activities [0.03%]
饮食和杏仁核活性对同笼小鼠血糖稳态和社会等级关联的调节作用研究
Rikako Ukichi,Yukari Takahashi,Momoyo Ibukuro et al.
Rikako Ukichi et al.
Recent clinical studies suggest that individual psychosocial traits play a significant role in the onset and progression of diabetes. To examine whether glucose homeostasis depends on the social rank of individual mice, we analyzed the effe...
EP4 stimulation promotes cell adhesion and migration via IL-6 signaling in oral squamous cell carcinoma [0.03%]
EP4刺激通过白介素-6信号促进口腔鳞癌细胞黏附和迁移
Wakana Fukae,Soichiro Ishikawa,Yu Iida et al.
Wakana Fukae et al.
Oral squamous cell carcinoma cell (OSCC) comprises malignant neoplasms arising within the oral cavity. Early-stage detection is associated with favorable prognosis, whereas progression to advanced stages with lymph node metastasis significa...