Synergistic protective effects of melatonin and ascorbic acid against benzene-induced genotoxicity, oxidative stress, and activin A/follistatin dysregulation in a rat model of pre-leukemia [0.03%]
褪黑素和抗坏血酸协同保护苯引起的遗传毒性和氧化应激以及激活素A/ follistatin在前白血病大鼠模型中的失调作用
Mohammed M Hussein M Raouf,Ismail M Maulood,Zrar Saleem Marzani
Mohammed M Hussein M Raouf
Benzene exposure is a major risk factor for hematologic malignancies, including acute myeloid leukemia (AML), through mechanisms involving genotoxicity, oxidative stress, and dysregulation of hematopoietic signaling pathways. This study inv...
Consideration of the applicability domain of an in silico physiologically based pharmacokinetic model for improving the predictivity of food-related compounds [0.03%]
考虑基于计算机的生理药代动力学模型的作用域以提高与食物相关化合物预测的准确性
Takuya Kikuchi,Yuuki Takahashi,Ayako Yamada et al.
Takuya Kikuchi et al.
The increasing demand for non-animal approaches in food safety assessment underscores the need for methods capable of predicting human internal exposure. We systematically evaluated the applicability of a physiologically based pharmacokinet...
Screening for putative epimutagens in neural stem cells derived from human induced pluripotent stem cells [0.03%]
基于人诱导多能干细胞的神经干细胞中潜在表观突变诱导物的筛选
Yoshikazu Arai,Koichiro Nishino
Yoshikazu Arai
The prevalence of pediatric neurological disorders has increased in recent years and has emerged as a major social concern. While genetic factors play a role, environmental factors may also contribute to these disorders, particularly exposu...
Charcoal hemoperfusion for aconite poisoning: Insights from a CKD case and complementary simulation experiments [0.03%]
雷公藤中毒的活性炭血浆灌注：一例慢性肾病患者的治疗启示及模拟实验补充研究
Yoshiaki Oshima,Akihiro Otsuki,Yukari Minami et al.
Yoshiaki Oshima et al.
Aconite contains four highly toxic diester-diterpene alkaloids (DDAs): aconitine, mesaconitine, hypaconitine, and jesaconitine. The efficacy of charcoal hemoperfusion (CHP) in treating aconite poisoning has recently been reported in several...
Lysosomal membrane permeabilization and lysosomal damage induced by silica micro/nanoparticles in murine RAW-Blue macrophages [0.03%]
硅微/纳米粒子诱导小鼠RAW-Blue巨噬细胞溶酶体膜透化和溶酶体损伤
Dipankar Chandra Roy,Kenji Ono,Katsumi Fukamachi et al.
Dipankar Chandra Roy et al.
The objective of this study was to examine the mechanisms underlying endocytic uptake, cytotoxicity, oxidative stress, and lysosomal damage caused by silica micro/nanoparticles (SiPs) in murine RAW-Blue macrophages. In parallel studies, we ...
Linalool inhalation‒induced anxiety-like effects occur independently of olfactory input and require cytochrome P450 activity [0.03%]
香料醇引起的焦虑样效应与嗅觉输入无关且需要细胞色素P450活性
Hideaki Sato,Ami Oguro,Masatsugu Miyara et al.
Hideaki Sato et al.
Multiple chemical sensitivity (MCS) is characterized by neuropsychological symptoms including anxiety, depression, and fatigue following exposure to environmental chemicals, yet its underlying mechanisms remain poorly understood. Linalool, ...
Protein homeostasis disruption in cisplatin-induced skeletal muscle atrophy: toxicological insights from experimental studies [0.03%]
顺铂诱导的骨骼肌萎缩中的蛋白质稳态紊乱：来自实验研究的毒理学见解
Hiroyasu Sakai,Risako Kon,Nobutomo Ikarashi et al.
Hiroyasu Sakai et al.
Cisplatin is a widely used platinum-based chemotherapeutic agent whose dose-limiting toxicities, including nephrotoxicity, neurotoxicity, and myelosuppression, have been extensively characterized. In contrast, skeletal muscle has not tradit...
A high-fat/high-sucrose/high-cholesterol diet leads to early indications of metabolic dysfunction-associated steatohepatitis-like lesions in obese diabetic mice [0.03%]
高脂/高果糖/高胆固醇饮食可诱导肥胖糖尿病小鼠出现代谢功能障碍相关性肝炎样病变早期表现
Kinuko Uno,Kodai Shirasaka,Yamato Muro et al.
Kinuko Uno et al.
Chronic hyperlipidemia and/ or hyperglycemia can impair various organs, such as the liver, kidney, and pancreas, through metabolic abnormalities. Metabolic dysfunction-associated steatohepatitis (MASH), related from nonalcoholic steatohepat...
Sensitivity of respiratory cell lines to unsaturated carbonyl compounds in cigarette smoke is regulated by intracellular glutathione [0.03%]
呼吸道细胞系对烟气中不饱和羰基化合物的敏感性受谷胱甘肽调节
Tsunehito Higashi,Fumito Naganuma,Yosuke Mai et al.
Tsunehito Higashi et al.
Cigarette smoking is a risk factor for various diseases, including chronic obstructive pulmonary disease (COPD). Cell death induced by cigarette smoke is one of the underlying causes of COPD. Unsaturated carbonyl compounds, such as acrolein...
Virtual internal exposures of lansoprazole administered to cytochrome P450 2C19 poor metabolizers estimated by simplified physiologically based pharmacokinetic modeling [0.03%]
基于简化的生理药动学模型估算兰索拉唑在细胞色素P450 2C19低代谢受试者中的虚拟内暴露量
Makiko Shimizu,Koichiro Adachi,Yukia Shimura et al.
Makiko Shimizu et al.
Although the importance of polymorphic cytochrome P450 2C19 (CYP2C19) in the metabolism of proton pump inhibitors is well recognized, genotyping patients for CYP2C19 before prescribing proton pump inhibitors is not currently recommended in ...