Bone metastasis: Interaction between cancer cells and bone microenvironment [0.03%]
骨转移：肿瘤细胞与骨微环境的相互作用
Toru Hiraga
Toru Hiraga
Background: Bone is one of the most common target organs for cancer metastasis, especially in patients with advanced breast and prostate cancers. Despite recent advances in therapeutic approaches, bone metastases remain i...
Recent trends of saliva omics biomarkers for the diagnosis and treatment of oral cancer [0.03%]
唾液组学生物标志物在口腔癌诊断和治疗中的最新研究进展
Indranil Chattopadhyay,Madhusmita Panda
Indranil Chattopadhyay
Background: Recent advances in surgery, radiotherapy, and chemotherapy have no significant effect on oral cancer survival rates due to late diagnosis, poor tumor response to chemotherapy and radiotherapy, as well as a lac...
Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing [0.03%]
基于16S rDNA测序的日本口腔癌患者菌群分析研究
Yasuharu Takahashi,Jonguk Park,Koji Hosomi et al.
Yasuharu Takahashi et al.
Objectives: It is important to determine the cause of increasing oral cancer occurrence and mortality rates in Japan, because the mortality rate has recently decreased in other developed countries. The impact of microbiot...
Mechanisms underlying the induction of regulatory T cells by sublingual immunotherapy [0.03%]
舌下免疫治疗诱导调节性T细胞的机制研究
Yukinori Tanaka,Satoshi Fukumoto,Shunji Sugawara
Yukinori Tanaka
Background: Sublingual immunotherapy (SLIT) is used for the treatment of type 1 allergies, such as allergic rhinitis. SLIT leads to tolerance against allergens possibly via the redirection of allergen-specific T helper 2 ...
Shinichiro Kuroshima,Muneteru Sasaki,Takashi Sawase
Shinichiro Kuroshima
Background: Antiresorptive agents such as bisphosphonates and denosumab, as well as angiogenesis inhibitors, may induce medication-related osteonecrosis of the jaw (MRONJ). However, the exact mechanisms of MRONJ are uncle...
Alternating lamellar structure in human cellular cementum and rat compact bone: Its structure and formation [0.03%]
人细胞牙骨质及大鼠密质骨交替层状结构的形成及其构造
Tsuneyuki Yamamoto,Tomoka Hasegawa,Hiromi Hongo et al.
Tsuneyuki Yamamoto et al.
Background: Human cellular cementum and compact bone exhibit an alternating lamellar structure, in which intensely and faintly stainable lamellae are stratified in an alternating manner. Many investigators, including our ...
Ramkumar Yadav,Mukesh Kumar
Ramkumar Yadav
Background: This review article discusses the effect of reinforcements in the parent dental restorative materials that results in enhanced performance in real-time situations. ...
Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure [0.03%]
磷脂酶C相关无活性蛋白：一种调节脂肪代谢和能量消耗的新信号分子
Takashi Kanematsu,Kana Oue,Toshiya Okumura et al.
Takashi Kanematsu et al.
Background: Overweight and obesity are defined as excessive or abnormal fat accumulation in adipose tissues, and increase the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coro...
Three-dimensional configuration of apical epithelial compartments including stem cell niches in guinea pig cheek teeth [0.03%]
豚鼠颊齿顶壁上皮腔包括干细胞生态位在内的三维结构配置
Yuta Seino,Mitsushiro Nakatomi,Hiroko Ida-Yonemochi et al.
Yuta Seino et al.
Objectives: Continuously growing rodent incisors have an apically located epithelial stem cell compartment, known as an "apical bud" (AB). Few studies have described the morphological features of ABs and stem cell niches ...
Role of nicotinic acetylcholine receptors for modulation of microcircuits in the agranular insular cortex [0.03%]
尼古丁乙酰胆碱受体在颗粒层缺乏的岛叶皮质微回路中的作用
Hiroki Toyoda
Hiroki Toyoda
Background: Acetylcholine (ACh) plays key roles in regulating neuronal excitability throughout the brain by acting muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs). The insular cortex is an important...