Genetic background influences the capacity for medial edge epithelium disintegration and phenotype of cleft palate in TGFβ3 knockout mice [0.03%]
基因背景影响TGFβ3敲除小鼠腭脑组织上皮细胞解聚及裂隙型腭裂表型的能力
Akiko Sugiyama,Toshiya Takigawa
Akiko Sugiyama
Objectives: Cleft palate is a frequent congenital craniofacial malformation of unknown etiology. Transforming growth factor (TGF) β3 is required for palatal shelf fusion. Although TGFβ3 knockout (KO) mice are widely use...
Epithelial TRPV1 channels: Expression, function, and pathogenicity in the oral cavity [0.03%]
口腔上皮TRPV1通道：表达、功能和致病性
Naoki Takahashi,Takahiro Tsuzuno,Shuhei Mineo et al.
Naoki Takahashi et al.
Background: The oral cavity serves as an entrance to the body and is therefore exposed to various exogenous stimuli, including mechanical forces, chemical agents, and bacterial components. The oral mucosa responds to thes...
Toshihisa Komori
Toshihisa Komori
Background: Osteocalcin is the most abundant non-collagenous protein in bone and is specifically expressed in osteoblasts. Previous studies using osteocalcin-deficient (Ocn-/-) mice demonstrated that osteocalcin inhibits ...
Emerging roles of microRNAs as extracellular vesicle cargo secreted from osteoblasts [0.03%]
微小核糖核酸作为骨细胞来源的胞外囊泡载体的作用机制及其在骨骼生理和疾病中的作用初探
Yuji Yoshiko,Tomoko Minamizaki
Yuji Yoshiko
Background: Extracellular vesicles (EVs) have come into the spotlight as messengers, delivering cargo for cell-cell communication. Concomitantly, increasing attention has been focused on microRNAs (miRNAs) as EV cargo. Be...
Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination [0.03%]
口腔鳞癌细胞系SQUU-A和SQUU-B的外泌体定义了淋巴播散趋向性
Masahiko Morioka,Tomoyo Kawakubo-Yasukochi,Yoshikazu Hayashi et al.
Masahiko Morioka et al.
Oral squamous cell carcinoma (OSCC) is often associated with lymphatic rather than hematogenous metastasis; however, a determinant factor for this process has not been elucidated. This study examined the effect of OSCC-derived exosomes on a...
Analysis of calcium, phosphorus, and carbon concentrations during developmental calcification of dentin and enamel in rat incisors using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) [0.03%]
扫描电镜能谱法分析大鼠门齿发育矿化过程中牙本质和釉质中钙、磷和碳的浓度分布
Kentaro Maruyama,Akiko Henmi,Hiroshi Okata et al.
Kentaro Maruyama et al.
Objective: The study was designed to investigate the concentrations of calcium (Ca), phosphorus (P), and carbon (C) during developmental calcification of dentin and enamel in rat incisors. ...
Degradation of bradykinin by a metalloendopeptidase from Streptococcus pyogenes [0.03%]
由链球菌产生的金属内肽酶降解缓激肽
Yoichi Miyamoto,Takaaki Akaike,Shigetada Kawabata et al.
Yoichi Miyamoto et al.
Objectives: Streptococcus pyogenes secretes streptococcal pyrogenic exotoxin B (SpeB), which cleaves kininogen to liberate bradykinin. In addition, this bacterium also has cell-associated bradykinin-degrading activity. He...
Proliferative activity of skeletal myoblast sheet by paracrine effects of mesenchymal stem cells [0.03%]
间充质干细胞旁分泌效应促进骨骼肌前体细胞增殖活性
Takashi Umezawa,Kazunari Higa,Masamitsu Serikawa et al.
Takashi Umezawa et al.
Objectives: The purpose of this study was to examine the proliferative activity enhancement of skeletal myoblasts in the presence and absence of mesenchymal stem cells (MSC). ...
Endothelial cell transplantation in tumors restores normal vasculature, reduces tumor hypoxia, and suppresses tumor outgrowth [0.03%]
内皮细胞移植可使肿瘤血管正常化、减少肿瘤缺氧并抑制肿瘤生长
Shuji Kitahara,Aya Matsui,Asuka Yoshii et al.
Shuji Kitahara et al.
Objectives: Vascular normalization, or restoration of the normal structure and function of blood vessels, using molecular-targeted therapy, has emerged as a potential strategy for treating malignant cancer and other vascu...
Dentin sialophosphoprotein is a potentially latent bioactive protein in dentin [0.03%]
牙本质糖磷蛋白是牙本质中潜在的生物活性蛋白质
Shigeki Suzuki,Jun Nakanishi,Kazuma Yoshida et al.
Shigeki Suzuki et al.
Background: Dentin sialophosphoprotein (DSPP) belongs to the family of small integrin-binding ligand N-linked glycoproteins (SIBLINGs), which share common biochemical features such as an arginine-glycine-aspartic acid (RG...