Herbal medicine Ninjinyoeito inhibits RANKL-induced osteoclast differentiation and bone resorption activity by regulating NF-κB and MAPK pathway [0.03%]
中药银杏地黄汤通过调节NF-κB和MAPK途径抑制RANKL诱导的破骨细胞分化及骨吸收作用
Kaung Htike,Kunihiro Yoshida,Takanori Eguchi et al.
Kaung Htike et al.
Objectives: Osteoporosis is a systemic bone metabolism disorder characterized by decreased bone mass and strength. Osteoclasts (OCs) are giant multinucleated cells that regulate bone homeostasis by degrading bone matrix. ...
Comparison of rhythmic jaw muscle activities induced by electrical stimulations of the corticobulbar tract during rapid eye movement sleep with those during wakefulness and non-rapid eye movement sleep in freely moving Guinea pigs [0.03%]
觉醒期和不同睡眠状态下皮质核束电刺激诱发的自由活动 Guinea 猪咬肌节律性运动比较研究
Makoto Higashiyama,Yuji Masuda,Ayano Katagiri et al.
Makoto Higashiyama et al.
Objective: Rhythmic jaw muscle activities (RJMAs) occur during rapid eye movement (REM) sleep in humans and animals even though motoneurons are inhibited. The present study compared the characteristics of jaw muscle activ...
Comparative Study
Journal of oral biosciences. 2024 Dec;66(4):58-66. DOI:10.1016/j.job.2024.09.004 2024
Potassium nitrate suppresses hyperactivities of Vc neurons of the model with dentin hypersensitivity [0.03%]
硝酸钾能抑制牙本质过敏模型小鼠Vc神经元的异常放电
Shiori Sugawara,Koichi Iwata,Toshiki Takamizawa et al.
Shiori Sugawara et al.
Objective: Potassium nitrate (KNO3) suppresses nociception induced by dental hypersensitivity (HYS). We aimed to examine the effects of KNO3 on the neural activity of the trigeminal spinal subnucleus caudalis (Vc) in HYS ...
Antihypertensive agent losartan promotes tongue squamous cell carcinoma cell proliferation via EGFR/ERK1/2/cyclin D1 signaling axis [0.03%]
血管紧张素Ⅱ受体拮抗剂洛沙坦促进舌鳞癌细胞增殖的机制研究
Luo-Yun Wu,Bor-Chyuan Su,Hsin-Hsien Yu et al.
Luo-Yun Wu et al.
Objective: To study the effects of losartan, an angiotensin II receptor blocker, in the SCC4 and SCC25 human tongue squamous cell carcinoma cell lines. Me...
Productions of Th2 cytokines, IL-4 and IL-10, were enhanced via the function of IL-2 from anti-CD3 antibody-stimulated mouse spleen cells treated with caffeic acid phenethyl ester [0.03%]
咖啡酸苯乙酯处理的抗CD3抗体刺激的小鼠脾细胞通过IL-2的作用增强Th2型细胞因子IL-4和IL-10的产生
Moe Takahashi,Masako Mizuno-Kamiya,Shifa Rahman et al.
Moe Takahashi et al.
Objectives: Interleukin (IL)-2 production by mouse spleen cells stimulated with an anti-CD3 antibody is significantly enhanced by caffeic acid phenethyl ester (CAPE), a major constituent of Chinese propolis (CP). In this ...
STAT3 interactome predicts presence of proteins that regulate immune system in oral squamous cell carcinoma [0.03%]
STAT3作用蛋白组预测口腔鳞状细胞癌中调节免疫系统的蛋白质的存在
Rajdeep Chakraborty,Pallavi Khodlan,Aidan Tay et al.
Rajdeep Chakraborty et al.
Objectives: Signal transducer and activator of transcription 3 (STAT3) is one of the key proliferation mechanism-related proteins that helps in oral squamous cell carcinoma (OSCC) progression. Immune evasion by STAT3 is m...
Y-27632 enables long-term expansion of mouse submandibular gland epithelial cells via inactivation of TGF-β1/CTGF/p38 and ROCK2/JNK signaling pathway [0.03%]
Y-27632通过抑制TGF-β1/CTGF/p38和ROCK2/JNK信号途径使小鼠下颌下腺上皮细胞长期增殖
Kichul Kim,Naeun Oh,Hyewon Kim et al.
Kichul Kim et al.
Objectives: This study aimed to investigate the effects of Y-27632 on the long-term maintainence of mouse submandibular epithelial cells (SG-Epis) in vitro and to elucidate the underlying mechanisms. ...
Sho Yoshida,Hiroaki Inaba,Ryota Nomura et al.
Sho Yoshida et al.
Objectives: Porphyromonas gulae is a major causative agent of periodontal disease in companion animals that possesses various virulence factors, including fimbriae, lipopolysaccharides, and proteases. P. gulae fimbriae ar...
Invasion of human dental pulp fibroblasts by Porphyromonas gingivalis leads to autophagy via the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling pathway [0.03%]
牙龈卟啉单胞菌通过磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路导致人牙髓成纤维细胞自噬入侵
Ying Feng,Mingxiang Liu,Yi Liu et al.
Ying Feng et al.
Objectives: Porphyromonas gingivalis is a pathogenic bacterium that causes periodontitis and dental pulp infection. Autophagy is a potential mechanism involved in inflammatory disease. This study established an in vitro m...
PLAG1 overexpression in salivary gland duct-acinar units results in epithelial tumors with acinar-like features: Tumorization of luminal stem/progenitor cells may result in the development of salivary gland tumors consisting of only luminal cells [0.03%]
唾液腺导管-腺泡单位中PLAG1过表达导致具有类似腺泡细胞特征的上皮肿瘤：腔体干细胞/前体细胞发生肿瘤后可能只产生由腔体细胞组成的唾液腺肿瘤
Yunosuke Ikeda,Rika Yasuhara,Junichi Tanaka et al.
Yunosuke Ikeda et al.
Objectives: Details about salivary gland tumor histogenesis remain unknown. Here, we established a newly generated murine salivary gland tumor model that could overexpress pleomorphic adenoma gene 1 (PLAG1) and attempted ...