Inhibition of Gremlin1 reduces osteoclast activation and alleviates inflammation-induced bone loss by disrupting the NF-κB signaling pathway [0.03%]
抑制Gremlin1可扰乱NF-κB信号通路，减少破骨细胞活化，缓解炎症诱导的骨质流失
Yuting Wang,Wenlan Li,Yifei Tang et al.
Yuting Wang et al.
Objectives: Gremlin1 plays a crucial role in the development of various inflammatory diseases that cause bone loss, including periodontitis and apical periodontitis (AP). The impact of Gremlin1 on osteoclast activation an...
Matrix metalloproteinase 9 expressed in satellite glial cells in the trigeminal ganglion contributes to tongue-cancer-associated pain [0.03%]
三叉神经节卫星胶质细胞表达的基质金属蛋白酶9参与舌癌相关痛觉过敏形成
Ryosuke Takahashi,Suzuro Hitomi,Yoshinori Hayashi et al.
Ryosuke Takahashi et al.
Objectives: Matrix metalloproteinase 9 (MMP9) degrades extracellular matrix and it is involved in cancer angiogenesis, invasion, and metastasis. However, the function of MMP9 within the trigeminal ganglion (TG) in tongue-...
Kento Nakanishi,Naoto Kamio,Takahiro Watanabe et al.
Kento Nakanishi et al.
Objectives: Dental pulp plays a crucial role in tooth homeostasis, and inflammation often leads to irreversible damage. Factor Xa (FXa), known for its role in coagulation, has recently been identified as an inflammatory m...
Piezo1 negatively regulates proliferation, but enhances mineralization in human cementoblasts [0.03%]
人牙骨质细胞中 Piezo1 负向调节细胞增殖但可增强矿化作用
Toshihiro Hasegawa,Takehito Ouchi,Ryuya Kurashima et al.
Toshihiro Hasegawa et al.
Objectives: Cementoblasts play essential roles in secreting collagenous and non-collagenous matrix proteins and in mineralization to produce cementum. Cementum is a mineralized tissue deposited in layers on the surface of...
Yujiro Hirose,Victor Nizet,Shigetada Kawabata
Yujiro Hirose
Background: Streptococcus pyogenes has several clinical manifestations, from mild pharyngitis to life-threatening necrotizing fasciitis. Nutrient conditions strongly influence its virulence, and the ability to metabolize ...
Hydroxyapatite-based cavitary varnish derived from eggshells: An in vitro analysis of dentin surface [0.03%]
取自鸡蛋壳的羟基磷灰石空心漆的体外分析：牙本质表面的研究
Ana Cláudia Dalmolin,Márcia Thaís Pochapski,Geovana Stafin et al.
Ana Cláudia Dalmolin et al.
Objectives: We aimed to evaluate the effectiveness of a cavitary varnish containing an experimental eggshell-derived hydroxyapatite (HA) on dentin surfaces. ...
Selene G Perales,Mia Rodriguez,Johnson Rajasingh et al.
Selene G Perales et al.
Background: Recent advancements in three-dimensional (3D) in vitro models have transformed dental research, offering more accurate and physiologically relevant platforms to study oral health and diseases. This review expl...
Preference for taste solutions within 10 minutes after starting to drink in water-deprived rats [0.03%]
禁水大鼠饮欲开始后10分钟内的饮水偏好试验结果
Izumi Manabe,Maho Yamazaki,Shinpei Takahashi et al.
Izumi Manabe et al.
Objective: To evaluate the preference for taste solutions with palatable and aversive qualities during the initial 10 min after resuming drinking in water-deprived rats. ...
Determination of Streptococcus gordonii novel adhesins specific to sialidase-treated erythrocytes [0.03%]
新型链球菌戈登菌定植素的鉴定及其与唾液酸酶处理过的红细胞的作用研究
Mayumi Uchikawa,Keitarou Saiki,Yuiko Ishikawa et al.
Mayumi Uchikawa et al.
Objectives: The Hsa/GspB adhesins of the oral bacterium Streptococcus gordonii are glycoproteins that bind to sialic acid. Hsa/GspB are peptidoglycan-associated proteins that have the Leu-Pro-X-Thr-Gly (LPXTG) motif and t...
Molecular mechanism of NF-κB-mediated transcriptional activation of MMP12 in lipopolysaccharide-stimulated human dental pulp stem cells [0.03%]
脂多糖刺激的人牙髓干细胞中NF-κB介导的基质金属蛋白酶12转录激活的分子机制
Yishu Xiao,Zhi Song,Derong Zeng et al.
Yishu Xiao et al.
Objectives: To investigate the molecular mechanisms through which matrix metalloprotein (MMP)12 exacerbates inflammation in pulpitis and to explore a potential regulatory axis between lipopolysaccharide (LPS)-induced MMP1...