Three-dimensional morphological analysis of ghrelin-producing cells in the rat fundic gland by combining serial section scanning electron microscopy and immunogold technique [0.03%]
结合连续切片扫描电镜及免疫金技术分析大鼠胃底腺生长抑素细胞三维形态学分布特征
Daisuke Koga,Satoshi Kusumi,Takahiro Sato
Daisuke Koga
Ghrelin-producing cells (ghrelin cells) in rat fundic glands were analyzed three-dimensionally by combining serial section scanning electron microscopy with immunogold labeling to elucidate their ultrastructural characteristics. This approa...
A novel 3D immuno-electron microscopy and its application to the Golgi apparatus [0.03%]
一种新的三维免疫电子显微镜技术及其在高尔基体中的应用
Daisuke Koga,Satoshi Kusumi,Hirokazu Yagi et al.
Daisuke Koga et al.
Serial section scanning electron microscopy (SEM) is useful for revealing the three-dimensional (3D) architecture of organelles by acquiring backscattered electron images of ultrathin serial sections of resin-embedded tissues on solid subst...
Tenascin-XB plays a role in the infiltration of immune cells in tumor microenvironment [0.03%]
肿瘤微环境中Tenascin-XB在免疫细胞浸润中的作用研究
Ao Gong,Yuichi Iida,Kohei Kawakami et al.
Ao Gong et al.
We previously showed that tenascin-XB (TNXB) contributes to tumor suppressor function. The present study aimed to assess the tumor-suppressive mechanism of TNXB by focusing on immune cell infiltration into the tumor microenvironment (TME). ...
Perfluorohexanesulfonic acid-induced inhibition of human palate cell proliferation through upregulation of miR-374a-5p [0.03%]
全氟己烷磺酸通过上调miR-374a-5p抑制人腭细胞增殖
Hiroki Yoshioka,Hanane Horita,Kenichi Ogata et al.
Hiroki Yoshioka et al.
Per- and poly fluoroalkyl substances (PFAS) pose significant global health risks. Although the use of classical PFAS such as perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) is regulated, the toxicological effects of a...
Analysis of HLA class I allele genotypes and immune-related gene alterations in patients with pan-cancer using whole-exome and whole-genome sequencing [0.03%]
基于外显子组和全基因组测序的肿瘤免疫分型及其临床意义分析
Akira Iizuka,Yasuto Akiyama,Tomoatsu Ikeya et al.
Akira Iizuka et al.
Noncompetitive inhibition of sodium-glucose cotransporter by unripe apple polyphenol extract in the mouse small intestine [0.03%]
未成熟的苹果多酚通过非竞争性抑制小肠的钠-葡萄糖共转运蛋白的作用机制
Shin-Ichiro Karaki,Kanoko Ichinose,Takahiro Sekikawa
Shin-Ichiro Karaki
The health benefits of apple polyphenols are well-documented. Phlorizin (Pz), an apple-derived polyphenol, is a known inhibitor of sodium-glucose cotransporters (SGLTs); however, the effects of other apple constituents on SGLTs remain uncle...
Radiation-induced changes in peripheral blood-derived mitochondrial DNA copy number and heteroplasmy in mice: Potential biomarkers of radiation exposure [0.03%]
辐射照射引起小鼠外周血源性线粒体DNA拷贝数及杂合子型变化：可能的放射损伤生物标志物研究
Ryosuke Seino,Yuka Takahashi,Hisanori Fukunaga
Ryosuke Seino
Radiological and nuclear accidents require reliable biomarkers for rapid detection of radiation exposure and dose estimation. While conventional biodosimetry has focused on nuclear DNA damage in lymphocytes, mitochondrial DNA (mtDNA) may pr...
A localized cAMP-Ca2+ signaling network in rat parotid acinar cells driven by the TAAR1 agonist RO5256390 [0.03%]
TAAR1激动剂RO5256390诱导的大鼠腮腺腺泡细胞cAMP-Ca2+信号通路的调控作用研究
Mayuko Ohno,Masato Hirakawa,Takuya Yokoyama et al.
Mayuko Ohno et al.
Trace amine-associated receptor 1 (TAAR1) is highly expressed in rat parotid acinar cells; however, its role in exocrine Ca2+ signaling remains unclear. We herein demonstrated that the selective TAAR1 agonist RO5256390 induced rapid and tra...
Chemical recognition of phytochemicals and microbiota-derived metabolites in the gut and implication for physiological function in the body [0.03%]
肠道中植物化学物质和微生物菌群衍生代谢物的化学识别及其对体内生理功能的影响
Atsukazu Kuwahara
Atsukazu Kuwahara
The gastrointestinal (GI) tract serves as a dynamic chemosensory interface that integrates signals from dietary phytochemicals and microbiota-derived metabolites to regulate host physiology. Beyond digestion and absorption, specialized epit...
Micheliolide alleviates oxygen-glucose deprivation/reoxygenation-evoked inflammation and ROS production in H9c2 cells [0.03%]
米契立醇通过减轻H9c2细胞中葡萄糖和氧气剥夺/复氧引起的炎症及ROS产生发挥保护作用
Qu Jin,Jinzhu Yin,Zhaozheng Liu et al.
Qu Jin et al.
Myocardial ischemia/reperfusion (I/R) injury can lead to substantial cardiac damage and pose a significant threat to human health and survival. Micheliolide (MCL), a sesquiterpene lactone extracted from Michelia (Magnoliaceae), has been rep...