Effects of propofol on the mRNA transcript abundance of CB1 receptors in rat brain [0.03%]
异丙酚对大鼠脑内CB1受体mRNA表达的影响
Atsuyuki Hosono,Masahiro Murakawa,Daisuke Kobayashi et al.
Atsuyuki Hosono et al.
This study aimed to elucidate the mechanism underlying tolerance to the sedative effects of propofol, focusing on cannabinoid 1 (CB1) receptor regulation. Male Wistar rats received continuous propofol infusion (30-40 mg/kg/h) for 1, 2, 4, o...
Localization of Type 1 plasminogen activator inhibitor in early decidua basalis and its role in pregnancy maintenance [0.03%]
蜕膜基底型第1种尿激酶型纤溶酶原激活物抑制剂的定位于其保胎作用
Yuka Sakakibara,Chizuko Yaguchi,Shuhei So et al.
Yuka Sakakibara et al.
Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor that controls trophoblast invasion by inhibiting fibrinolysis at the feto-maternal interface. This study aimed to compare PAI-1 expression patterns in decidual cells b...
Mitsunari Nakajima,Ren Shimizu,Atsushi Sawamoto et al.
Mitsunari Nakajima et al.
Many scientists are interested in anti-aging interventions and seek to identify anti-aging medicines. In our previous study, we reported that an antitussive drug, tipepidine (TIP), activates AMP-activated protein kinase (AMPK) and improves ...
Constant cGAS activation blunts STING signaling in DU145 prostate cancer cell line [0.03%]
人前列腺癌DU145细胞系中cGAS持续活化抑制STING信号转导
Eisuke Yumoto,Kenji Iemura,Kozo Tanaka
Eisuke Yumoto
The cGAS-STING pathway is an innate immune pathway that senses microbial and host-derived double-stranded DNA in the cytosol, and triggers type I interferon responses and proinflammatory cytokine production. Recently, activation of the cGAS...
CaMKII promotes BCR-induced apoptosis through Bcl-xL downregulation in immature B cells [0.03%]
CaMKII通过下调Bcl-xL促进前B细胞BCR诱导的凋亡
Ryosuke Okubo,Ryutaro Kajihara
Ryosuke Okubo
B cell antigen receptor (BCR) signaling plays a critical role in regulating B cell fate, including activation, tolerance, and apoptosis. In immature B cells, strong BCR engagement induces apoptosis, which contributes to the elimination of a...
Atomic force microscopy identifies filamentous structures comprising mitotic chromosomes [0.03%]
原子力显微镜识别了组成有丝分裂染色体的纤维状结构
Moeri Suzuki,Motoko Takahashi,Toru Hirota et al.
Moeri Suzuki et al.
Chromosomes undergo dynamic structural reorganization during the cell cycle and become highly condensed during mitosis. This condensation process involves the assembly of chromatin fibers, in which chromosome-associated proteins (e.g., cond...
Compressed residual green tea extract prevents capillary regression by inhibiting slow-to-fast muscle fiber transformation in the atrophied skeletal muscle [0.03%]
压缩绿茶提取物通过抑制肌纤维转化来预防萎缩骨骼肌中毛细血管回缩
Nao Fujino,Pan Han,Hiroyo Kondo et al.
Nao Fujino et al.
Disuse induces capillary regression in skeletal muscle, which is associated with excessive production of reactive oxygen species (ROS), impaired mitochondrial oxidative capacity, and a shift from slow- to fast-twitch muscle fibers. Green te...
Habitual exercise prior to intracerebral hemorrhage primes brain environment against injury in a dose-dependent manner of the exercise [0.03%]
在脑出血前经常锻炼可以以剂量依赖性方式减少对大脑的损伤
Yuichiro Oka,Takuya Sugiyama,Ke Chen et al.
Yuichiro Oka et al.
Intracerebral hemorrhage (ICH) is a devastating form of stroke with limited treatment options. Although exercise is beneficial in ischemic stroke, its preconditioning effects in hemorrhagic stroke remain unclear. We examined whether volunta...
Ultrastructural spectrum of oncocytic and chromophobe renal tumors: Insights from osmium maceration-based scanning electron microscopy of formalin-fixed tissues [0.03%]
基于锇下沉的扫描电子显微镜对固定肾肿瘤样本进行观测所得的嗜酸性和嫌色性肾肿瘤亚细胞结构谱系的新见解
Taro Murakami,Daisuke Koga,Mayuko Akimoto et al.
Taro Murakami et al.
Ultrastructural analysis has declined in diagnostic pathology since the advent of immunohistochemistry for formalin-fixed paraffin-embedded tissues. To reevaluate the utility of ultrastructural analysis, we adopted the osmium maceration met...
Differences in tumor-associated cytokine production and immune mechanisms between myofibroblastic cancer associated fibroblasts and myofibroblasts [0.03%]
肿瘤相关细胞因子产生及免疫机制的癌相关成纤维细胞与肌成纤维细胞之间的差异性研究
Kosei Kubota,Ken Furudate,Tomoh Matsumiya et al.
Kosei Kubota et al.
Despite advances in oral cancer treatment, therapeutic resistance remains a major challenge. Cancer-associated fibroblasts (CAFs) play a pivotal role in shaping the tumor microenvironment. Building on our previous findings on immune respons...