Lack of Evidence for Kynurenine Pathway Dysfunction in Huntington's Disease: CSF and Plasma Analyses from the HDClarity Study [0.03%]
亨廷顿舞蹈病缺乏色氨酸代谢通路功能障碍的证据：来自HDClarity研究的脑脊液和血浆分析结果
Vinod Khetarpal,Todd Herbst,Celia Dominguez et al.
Vinod Khetarpal et al.
Background: Evidence from animal studies and post-mortem studies of brains from people with Huntington's disease (PwHD) has suggested that the kynurenine pathway (KP) may be dysregulated in Huntington's disease (HD). ...
Jared T Hinkle,Erin Wildermuth,Xiao J Tong et al.
Jared T Hinkle et al.
Background: Anosognosia, or unawareness of symptoms, is common in Huntington's disease (HD), but the neuroanatomical basis of this is unknown. Objective: ...
Changes in 24(S)-Hydroxycholesterol Are Associated with Cognitive Performance in Early Huntington's Disease: Data from the TRACK and ENROLL HD Cohorts [0.03%]
24S-羟基胆固醇的变化与早期亨廷顿舞蹈病认知表现的关系：来自TRACK和ENROLL HD队列的数据
Sarah M Gray,Jing Dai,Anne C Smith et al.
Sarah M Gray et al.
Background: There is evidence for dysregulated cholesterol homeostasis in Huntington's disease (HD). The brain-specific cholesterol metabolite 24(S)-hydroxycholesterol (24(S)-OHC) is decreased in manifest HD. 24(S)-OHC is...
Magnetic Resonance Imaging to Detect Structural Brain Changes in Huntington's Disease: A Review of Data from Mouse Models [0.03%]
磁共振成像在亨廷顿舞蹈病中的应用：小鼠模型数据回顾性分析以检测结构性脑改变
Jenna Hanrahan,Drew P Locke,Lindsay S Cahill
Jenna Hanrahan
Structural magnetic resonance imaging (MRI) is a powerful tool to visualize 3D neuroanatomy and assess pathology and disease progression in neurodegenerative disorders such as Huntington's disease (HD). The development of mouse models of HD...
Huntington's Disease-Related Mortality Patterns: A Two-Decade Analysis of Mortality Trends in the United States, from 1999-2019 [0.03%]
亨廷顿病相关死亡模式：对美国1999年至2019年期间的死亡率趋势进行为期二十年的分析
Muhammad Arham Bin Kashif,Samar Mahmood,Tahrim Saqib et al.
Muhammad Arham Bin Kashif et al.
Background: Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder debilitating mainly in adults. Objective: ...
Rasch Measurement Theory (RMT) Analyses of the Huntington's Disease Everyday Functioning (Hi-DEF) to Evaluate Item Fit and Performance [0.03%]
拉什测量理论（RMT）分析亨廷顿舞蹈病日常功能量表（Hi-DEF）以评价项目适应性和表现力
Jennifer Petrillo,Ruta Sawant,Emma Elliott et al.
Jennifer Petrillo et al.
Background: The Huntington's Disease (HD) Everyday Functioning (Hi-DEF) is a new patient-reported outcome (PRO) instrument designed to measure the impact of cognitive impairment on daily functioning in the early stages of...
Observational Study
Journal of Huntington's disease. 2024;13(3):385-397. DOI:10.3233/JHD-240001 2024
Abigail L B Snow,Abagail E Ciriegio,Kelly H Watson et al.
Abigail L B Snow et al.
Background: Huntington's disease (HD) presents patients and individuals at risk for HD with significant levels of stress. However, relatively little research has examined how individuals cope with stress related to the di...
Economic Burden of Huntington's Disease: Analysis from a Brazilian Tertiary Care Perspective [0.03%]
巴西三级医疗保健视角下的亨廷顿病的经济负担分析
Andressa da Silva van der Laan,Vanderci Borges,Roberta Arb Saba et al.
Andressa da Silva van der Laan et al.
Background: Huntington's disease (HD) exerts significant impacts on individuals and families worldwide. Nevertheless, data on its economic burden in Brazil are scarce, revealing a critical gap in understanding the associa...
Observational Study
Journal of Huntington's disease. 2024;13(3):349-356. DOI:10.3233/JHD-240025 2024
Prevalence of Juvenile-Onset and Pediatric Huntington's Disease and Their Availability and Ability to Participate in Trials: A Dutch Population and Enroll-HD Observational Study [0.03%]
荷兰人群和Enroll-HD观察研究中青少年及儿童亨廷顿舞蹈病的患病率及其参与临床试验的情况与能力
Hannah S Bakels,Stephanie Feleus,Mar Rodríguez-Girondo et al.
Hannah S Bakels et al.
Background: Juvenile-onset Huntington's disease (JHD) represents 1-5% of Huntington's disease (HD) patients, with onset before the age of 21. Pediatric HD (PHD) relates to a proportion of JHD patients that is still under ...
Observational Study
Journal of Huntington's disease. 2024;13(3):357-368. DOI:10.3233/JHD-240034 2024
Promoting Physical Activity in Huntington's Disease: Co-Design of a Care Partner Resource [0.03%]
亨廷顿舞蹈病的体力活动推广：护工资源的联合设计
Una Jones,Katy Hamana,Monica Busse
Una Jones
Background: Clinical guidelines recommend that people with Huntington's disease (HD) should exercise to maintain/improve fitness and motor function, yet physical activity levels remain low in this group. Promotion of phys...