Anosognosia and avoidant coping do not impact work in early Huntington's disease [0.03%]
厌症和回避性应对不会影响早发型亨廷顿舞蹈病患者的工作能力
Kasper Frederik van der Zwaan,Raymund Ac Roos,Susanne T de Bot
Kasper Frederik van der Zwaan
BackgroundWork plays a crucial role in life, contributing to financial stability and well-being. Huntington's disease (HD), a genetic neurodegenerative disorder, can significantly affect work capacity. Anosognosia (lack of awareness of impa...
Childhood trauma and psychological distress during adulthood in children from Huntington's disease families: An exploratory retrospective analysis [0.03%]
亨廷顿病家庭儿童的童年创伤及成年期的心理困扰：一项探索性研究
Sabrina Maffi,Nicolò Zarotti,Marta Scocchia et al.
Sabrina Maffi et al.
BackgroundChildren of people with Huntington's disease (HD) often face a wide range of early psychological challenges which may lead to further psychological difficulties later in life.ObjectiveThis exploratory retrospective study aimed to ...
Dysregulated astrocyte cholesterol synthesis in Huntington's disease: A potential intersection with other cellular dysfunctions [0.03%]
亨廷顿舞蹈病中星形胶质细胞胆固醇合成失调：与其他细胞功能障碍潜在交汇点的可能性
Marta Valenza
Marta Valenza
Astrocytes are key elements for synapse development and function. Several astrocytic dysfunctions contribute to the pathophysiology of various neurodegenerative disorders, including Huntington's disease (HD), an autosomal-dominant neurodege...
Mena Farag,Sarah J Tabrizi,Edward J Wild
Mena Farag
In this edition of the Huntington's Disease Clinical Trials Update, we expand on the ongoing phase I clinical trial of ALN-HTT02 from Alynlam Pharmaceuticals. We also report on the SAGE-718 (also known as dalzanemdor) program from Sage Ther...
Upregulation of endocannabinoid signaling in vivo restores striatal synaptic plasticity and motor performance in Huntington's disease mice [0.03%]
体内上调内源大麻素信号转导可恢复亨廷顿舞蹈病小鼠纹状体突触可塑性和运动表现能力
Marja D Sepers,Cameron L Woodard,Daniel Ramandi et al.
Marja D Sepers et al.
BackgroundSynaptic dysfunction underlies early sensorimotor and cognitive deficits in Huntington's disease (HD) and precedes the degeneration of striatal spiny projection neurons and cortical pyramidal neurons. Movement selection and motor ...
Functional Rating Scale 2.0 (FuRST 2.0): A patient-reported outcome measure of function for Huntington's disease [0.03%]
亨廷顿病功能测量量表2.0（ FuRST 2.0）：用于评价亨廷顿病患者报告的功能转归的工具
Rebecca Lm Fuller,Pua Feigenbaum,Nancy LaPelle et al.
Rebecca Lm Fuller et al.
BackgroundCurrent functional rating scales are not sensitive to the earliest functional changes in Huntington's disease (HD).ObjectiveThe Functional Rating Scale 2.0 (FuRST 2.0) is a patient-reported outcome (PRO) measure designed to be sen...
Asymmetric brain atrophy in Huntington's disease: A postmortem MRI study [0.03%]
亨廷顿舞蹈病的不对称脑萎缩：一项尸检MRI研究
Eardi Lila,David Hunt,Daniel D Child et al.
Eardi Lila et al.
BackgroundHuntington's disease is a progressive, autosomal dominant, neurodegenerative disease caused by a CAG repeat expansion in the HTT gene. Medium spiny neurons of the striatum are especially vulnerable to the disease, and atrophy of t...
A systematic review of performance-based functional capacity measures for use in Huntington's disease and evaluation of their suitability for clinical trials [0.03%]
基于性能的功能容量测量在亨廷顿病中的系统评价及其临床试验适用性的评估
Tayela M Prichard,Cali M Roiboit,Meg E Rankin et al.
Tayela M Prichard et al.
BackgroundHuntington's disease (HD) leads to a decline in functional capacity, affecting daily life tasks. Assessing functional capacity in clinical trials is crucial to evaluate treatment effectiveness and substantiate the clinical meaning...
Emerging roles of microglia and neuroinflammation in Huntington's disease: From pathophysiology to clinical trials [0.03%]
小胶质细胞和神经炎症在Huntington病中的新角色：从病理生理学到临床试验
Muna Abedrabbo,Pardis Kazemian,Colúm Connolly et al.
Muna Abedrabbo et al.
Microglia, the resident immune cells of the central nervous system, play a pivotal role in the response to Huntington's disease (HD) pathology. Through both cell-autonomous mechanisms and exposure to external pathogenic stimuli, microglia t...
Wenzhen Duan,Yuan Zhou,Hongshuai Liu
Wenzhen Duan
The glymphatic system, a macroscopic waste clearance network in the brain, plays a vital role in maintaining neuronal health and brain homeostasis. Functionally analogous to the lymphatic system in other organs, the term "glymphatic" combin...