Effects of computerized cognitive training on functional activity and connectivity in Huntington's disease: A pilot study [0.03%]
计算机认知训练对亨廷顿病患者功能活动和脑网络连接的影响：一项初步研究
Katharine Huynh,Nellie Georgiou-Karistianis,Amit Lampit et al.
Katharine Huynh et al.
BackgroundComputerized cognitive training (CCT) has been found to improve cognition by altering functional activity and functional connectivity of brain networks in people with and without cognitive impairment. The effects of CCT on functio...
Mena Farag,Sarah J Tabrizi,Edward J Wild
Mena Farag
In this edition of the Huntington's Disease Clinical Trials Update, we expand on the launch of the phase II/III clinical trial of SKY-0515 from Skyhawk Therapeutics and the phase I/II clinical trial of SPK-10001 from Spark Therapeutics. We ...
Huntington's as a developmental disorder: Molecular and neuropathologic considerations [0.03%]
亨廷顿病的发育特性：分子和神经病理学考虑因素
Mallory R Shin,Marco M Hefti
Mallory R Shin
Huntington's disease (HD) is classically characterized as a late-onset neurodegenerative disorder of adulthood caused by CAG expansion in the HTT gene. However, mounting evidence from both human and experimental studies suggests that both w...
Early life functional advantage coupled with accelerated aging: The case for antagonistic pleiotropy in Huntington's disease [0.03%]
早年功能优势与加速衰老相结合：亨廷顿舞蹈病中对抗性多效性的案例
Jordan L Schultz,Peg C Nopoulos
Jordan L Schultz
Recent findings suggest that neurodevelopment plays a critical role in Huntington's Disease (HD) pathogenesis. This review integrates data from human studies of children and young adults at risk for HD (the Kids-HD study) with the theory of...
Emotion recognition in people with Huntington's disease: A comprehensive systematic review [0.03%]
亨廷顿病患者的情绪识别：全面的系统综述
Nicolò Zarotti,Alice Storey,Sarah Lloyd et al.
Nicolò Zarotti et al.
BackgroundDeficits of emotion recognition have received increasing attention in people with Huntington's disease (HD) in the three decades since the discovery of the HD gene. However, the characterisation of such deficits across different d...
Huntingtin knockdown dysregulates autophagic degradation of Apolipoprotein E [0.03%]
亨廷顿蛋白敲低干扰载脂蛋白E的自噬降解作用
Gianna M Fote,Nicolette R McClure,Robert M Bragg et al.
Gianna M Fote et al.
BackgroundThe HTT protein, mutated in Huntington's disease, is expressed throughout the body, and loss of HTT function as an autophagic scaffold may affect tissues and cellular processes. These processes include lipid metabolism potentially...
Morphological and functional phenotyping of skeletal muscle and bone in the zQ175 knock-in mouse model of Huntington's disease [0.03%]
亨廷顿舞蹈病zQ175基因敲入小鼠骨骼肌和骨的形态学及功能表型研究
Behnaz Nateghi,Mohamed Lala Bouali,Zineb Bouredji et al.
Behnaz Nateghi et al.
Background: Huntington's disease (HD) is a progressive neurodegenerative disorder primarily affecting the central nervous system (CNS). However, emerging evidence suggests that peripheral tissues, including skeletal muscle and bone, also un...
Effective housing and support models for people with Huntington's disease: A scoping review [0.03%]
亨廷顿病患者的高效住房与支持模式：一项概要性综述
Lee Cubis,Elise Davis,Sharyn McDonald et al.
Lee Cubis et al.
BackgroundPeople with Huntington's disease (HD) experience physical, cognitive, and psychiatric manifestations that can result in housing in settings that are inappropriate for care requirements.ObjectiveThe aim of this scoping review was t...
Isometric force matching in the TRACK-HD study - a novel quantitative assessment for clinical applications? [0.03%]
TRACK-HD研究中的等轴力匹配-一种新型的定量评估方法用于临床应用吗？
Robin Schubert,Pascal Barallon,Benjamin Habbel et al.
Robin Schubert et al.
BackgroundHuntington's disease is a rare, progressive, neurodegenerative disease. Capturing symptomatic progression and treatment effects reliably in clinical therapeutic trials has shown to be a challenging task, facing the problem of smal...
Reply to: In Response to Fuller et al., Functional Rating Scale 2.0 (FuRST 2.0): A patient-reported outcome measure of function for Huntington's disease [0.03%]
FuRST 2.0量表（ FuRST 2.0：亨廷顿病的功能预后评估量表）回复富勒等人的文章
Neha Sinha,Rebecca Lm Fuller,Glenn T Stebbins
Neha Sinha