The Appointment of a Huntington's Disease Nurse Specialist has Reduced Admission Rate and Improved Admission Quality [0.03%]
聘用亨廷顿舞蹈病专科护士降低了住院率并提高住院质量
David Bourke,Gregory Finucane,Jo Dysart et al.
David Bourke et al.
We aimed to determine if the appointment of a Huntington's disease (HD) nurse specialist has influenced inpatient admission rates and admission quality at Auckland Hospital. We collated HD inpatient admission data for the 32 months before a...
Functional Differences Between Direct and Indirect Striatal Output Pathways in Huntington's Disease [0.03%]
亨廷顿病中直接和间接纹状体通路的功能差异
Laurie Galvan,Véronique M André,Elizabeth A Wang et al.
Laurie Galvan et al.
There is morphological evidence for differential alterations in striatal medium-sized spiny neurons (MSNs) giving rise to the direct and indirect output pathways in Huntington's disease (HD). MSNs of the indirect pathway appear to be partic...
Asa Petersén,Sanaz Gabery
Asa Petersén
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Today, the clinical diagnosis of the disease requires unequivocal signs of typical motor disturbances, which is thought to be...
Alice Wexler
Alice Wexler
Although the disease today known as Huntington's was described as early as the mid-19th century, knowledgeable physicians despaired of finding successful therapies and affected families largely kept it hidden. Starting in the late 1960 s, t...
Blair R Leavitt,Leslie M Thompson
Blair R Leavitt
β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease [0.03%]
β-防御素基因组拷贝数不影响亨廷顿舞蹈病的发病年龄
Angelica Vittori,Michael Orth,Raymund A C Roos et al.
Angelica Vittori et al.
Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the abnormal expansion of a CAG triplet repeat tract in the huntingtin gene. While the length of this CAG expansion is th...
Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons [0.03%]
CDK5活化剂p25和p35水平的下降可减少纹状体神经元的兴奋毒性损伤
Kevin H J Park,Ge Lu,Jing Fan et al.
Kevin H J Park et al.
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG trinucleotide repeat sequence in the huntingtin gene. The resulting poly-glutamine expansion in the huntingtin protein imparts a novel toxic gai...
Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease [0.03%]
亨廷顿舞蹈病转基因小鼠心脏功能障碍的直接证据
Nigel I Wood,Stephen J Sawiak,Guido Buonincontri et al.
Nigel I Wood et al.
HD is a progressive genetic neurological disorder, characterized by motor as well as cognitive impairments. The gene carrying the mutation causing Huntington's disease (HD) is not brain specific, and there is increasing evidence for periphe...
Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules [0.03%]
小分子检测突变型亨廷顿蛋白聚集结构并调节其SDS可溶性纤维状寡聚体的能力
Emily Mitchell Sontag,Gregor P Lotz,Guocheng Yang et al.
Emily Mitchell Sontag et al.
The Huntington's disease (HD) mutation leads to a complex process of Huntingtin (Htt) aggregation into multimeric species that eventually form visible inclusions in cytoplasm, nuclei and neuronal processes. One hypothesis is that smaller, s...
Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background [0.03%]
HTT CAG140小鼠兴奋毒性抵抗的年龄依赖性及其背景基因型的影响
Melissa K Strong,Amber L Southwell,Jennifer M Yonan et al.
Melissa K Strong et al.
Mouse strain background can influence vulnerability to excitotoxic neuronal cell death and potentially modulate phenotypes in transgenic mouse models of human disease. Evidence supports a contribution of excitotoxicity to the selective deat...
Comparative Study
Journal of Huntington's disease. 2012;1(2):221-41. DOI:10.3233/JHD-129005 2012