Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1 [0.03%]
多聚谷氨酰胺扩增的亨廷顿蛋白改变HSF1结合基因组的范围
Laura Riva,Martina Koeva,Ferah Yildirim et al.
Laura Riva et al.
In Huntington's disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock...
Genetic Deficiency of Complement Component 3 Does Not Alter Disease Progression in a Mouse Model of Huntington's Disease [0.03%]
补体成分C3遗传缺乏不影响亨廷顿舞蹈病小鼠模型的疾病进展
Paul B Larkin,Paul J Muchowski
Paul B Larkin
Several genes and proteins of the complement cascade are present at elevated levels in brains of patients with Huntington's disease (HD). The complement cascade is well characterized as an effector arm of the immune system, and in the brain...
Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice [0.03%]
猎тин틴脯氨酸富集区的缺失不影响小鼠中正常猎틴틴的功能
Michelle Neveklovska,Erin B D Clabough,Joan S Steffan et al.
Michelle Neveklovska et al.
The N-terminus of Huntingtin, the protein encoded by the Huntington's disease gene, contains a stretch of polyglutamine residues that is expanded in Huntington's disease. The polyglutamine stretch is flanked by two conserved protein domains...
Huntington's disease at work: The effect of profession-specific requirements as related to clinical characteristics on work outcome [0.03%]
工作中的亨廷顿病：与临床特征相关的特定职业要求对工作结果的影响
Background: In most Huntington's disease expanded gene carriers (HDEGC), losing work capacity is the first sign of functional decline. Cognitive deterioration, motor dysfunction, and psychiatric disturbances are associate...
Acceptance and commitment therapy with Huntington's disease: A narrative review and case report of a caregiver-assisted intervention [0.03%]
与亨廷顿氏病患者接受承诺疗法：一项叙述性综述和一个由看护者协助的干预案例报告
Acceptance and commitment therapy (ACT) is an experiential, action-oriented talk therapy that emphasizes acceptance of painful inner experience through increased psychological flexibility. In this narrative review and case report, we first ...