Improved Executive Function and Callosal White Matter Microstructure after Rhythm Exercise in Huntington's Disease [0.03%]
节奏训练改善亨廷顿舞蹈病患者的执行功能并促进胼胝体微结构的重塑
Claudia Metzler-Baddeley,Jaime Cantera,Elizabeth Coulthard et al.
Claudia Metzler-Baddeley et al.
Background: Huntington's disease (HD) is an autosominal dominant neurodegenerative condition that leads to progressive loss of motor and cognitive functions. Early symptoms in HD include subtle executive dysfunction relat...
Clinical Trial
Journal of Huntington's disease. 2014;3(3):273-83. DOI:10.3233/JHD-140113 2014
Huntingtin Supplies a csaA-Independent Function Essential for EDTA-Resistant Homotypic Cell Adhesion in Dictyostelium discoideum [0.03%]
猎庭丁蛋白提供一种非csaA依赖的功能对Dictyostelium discoideum的乙二胺四乙酸耐受的同型细胞粘附是必不可少的
Morgan N Thompson,Marcy E MacDonald,James F Gusella et al.
Morgan N Thompson et al.
Background: The CAG triplet repeat expansion mutation in the HTT locus, which results in neurodegeneration in Huntington's disease, elongates a polyglutamine tract in huntingtin, a HEAT/HEAT-like protein that has been hig...
TR-FRET Assays for Endogenous Huntingtin Protein Level in Mouse Cells [0.03%]
用于小鼠细胞内亨廷顿蛋白(TR-FRET检测法)
Yijian Liang,Yuwei Yao,Mingxing Lu et al.
Yijian Liang et al.
High-throughput measurement of huntingtin (Htt) levels is useful for Huntington's disease research. For example, identification of genetic or chemical modifiers that reduce Htt levels by high-throughput screening provides promising strategy...
Understanding the Outcomes Measures used in Huntington Disease Pharmacological Trials: A Systematic Review [0.03%]
系统综述：亨廷顿病药物临床试验的疗效评价指标
Noelle E Carlozzi,Angela Miciura,Nicholas Migliore et al.
Noelle E Carlozzi et al.
Background: The identification of the gene mutation causing Huntington disease has raised hopes for new treatments to ease symptoms and slow functional decline. As such, there has been a push towards designing efficient p...
Perhaps the subject of the questionnaire was too sensitive: Do we expect too much too soon? Wishes for the end of life in Huntington's Disease - the perspective of European physicians [0.03%]
也许问卷调查的主题太敏感了：期望值过高了吗？欧洲医生对于亨廷顿舞蹈病患者末期愿望的视角
Suzanne J Booij,Aad Tibben,Dick P Engberts et al.
Suzanne J Booij et al.
David R Borchelt,Christopher A Ross
David R Borchelt
Amber L Southwell,Nancy S Wexler
Amber L Southwell
Direct Visualisation of Abnormal Dendritic Spine Morphology in the Hippocampus of the R6/2 Transgenic Mouse Model of Huntington's Disease [0.03%]
亨廷顿舞蹈病R6/2转基因小鼠海马区异常突触棘形态的直接观察法
Simon J Bulley,Cheney J G Drew,A Jennifer Morton
Simon J Bulley
Background: Spatial learning deficits are observed in R6/2 mice, a transgenic mouse model of Huntington's Disease (HD). Spatial learning is a hippocampal-dependent process, and impairment of memory is thought to be due, a...
Antidepressant-Like Effect of the Norepinephrine-Dopamine Reuptake Inhibitor Bupropion in a Mouse Model of Huntington's Disease with Dopaminergic Dysfunction [0.03%]
多巴胺能功能障碍亨廷顿舞蹈病小鼠模型中抗抑郁药溴西亚平的作用
Thibault Renoir,Andrew Argyropoulos,Anthony J Hannan
Thibault Renoir
Background: The pre-motor stages of Huntington's disease (HD) are commonly associated with psychiatric manifestations including depression. Recent clinical data indicate that dopaminergic dysfunction is common in both sym...
Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo [0.03%]
抗半胱天冬酶6猎物蛋白突变体不能挽救半胱天冬酶可裂解猎物蛋白突变体的毒性作用
Rona K Graham,Yu Deng,Mahmoud A Pouladi et al.
Rona K Graham et al.
Background: The amelioration of behavioral and neuropathological deficits in mice expressing caspase-6-resistant (C6R) mutant huntingtin (mhtt), despite the presence of an expanded polyglutamine tract, highlights proteoly...