Functional Brain Correlates of Neuropsychiatric Symptoms in Presymptomatic Huntington's Disease: The IMAGE-HD Study [0.03%]
影像学研究：渐进性亨廷顿舞蹈病患者前症状期的精神病症状的功能脑相关因素：IMAGE-HD 研究
Govinda R Poudel,Shannon Driscoll,Juan F Domínguez D et al.
Govinda R Poudel et al.
Background: Neuropsychiatric disturbances are common in Huntington's Disease (HD) and have been observed in gene-positive individuals several years prior to the onset of motor symptoms. The neural mechanism underpinning t...
Andreas-Antonios Roussakis,Paola Piccini
Andreas-Antonios Roussakis
To date, little is known about how neurodegeneration and neuroinflammation propagate in Huntington's disease (HD). Unfortunately, no treatment is available to cure or reverse the progressive decline of function caused by the disease, thus c...
Determinants of Onset of Huntington's Disease with Behavioral Symptoms: Insight from 92 Patients [0.03%]
92例亨廷顿舞蹈病患者的临床分析：行为症状起病亚群的特点及影响因素分析
Abhishek Lenka,Nitish L Kamble,V Sowmya et al.
Abhishek Lenka et al.
Background: Huntington's disease (HD) is a genetically mediated neurodegenerative disorder characterized by presence of involuntary movements, behavioral problems and cognitive dysfunctions. Though few patients with HD ma...
Brain Cholesterol Synthesis and Metabolism is Progressively Disturbed in the R6/1 Mouse Model of Huntington's Disease: A Targeted GC-MS/MS Sterol Analysis [0.03%]
亨廷顿舞蹈病小鼠模型R6/1中脑胆固醇合成和代谢的紊乱：气相色谱质谱法分析甾醇类化合物的研究
Fabian Kreilaus,Adena S Spiro,Anthony J Hannan et al.
Fabian Kreilaus et al.
Background: Cholesterol has essential functions in neurological processes that require tight regulation of synthesis and metabolism. Perturbed cholesterol homeostasis has been demonstrated in Huntington's disease, however...
Loss of the Sexually Dimorphic Neuro-Inflammatory Response in a Transgenic Mouse Model of Huntington's Disease [0.03%]
亨廷顿舞蹈病转基因小鼠性二态神经炎症反应缺失
Thibault Renoir,Terence Y Pang,Yoshiko Shikano et al.
Thibault Renoir et al.
Background: We previously reported sex differences in depression-like behaviours in a mouse model of Huntington's disease (HD). Objective: ...
Productivity and Impact of the Top 100 Cited Huntington's Disease Investigators [0.03%]
高被引亨廷顿病研究者们的生产力及影响
Aaron A Sorensen,M&#x;hamed El Aisati,David Weedon
Aaron A Sorensen
Huntington's disease (HD), research has grown dramatically over the last 25 years of research to the point where an analysis of productivity is warranted. We have compiled a list of the 100 most-cited researchers in HD together with H-Indic...
The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease [0.03%]
亨廷顿舞蹈病运动起病年龄遗传修饰因素（GeM MOA）网站：全基因组关联分析揭示亨廷顿舞蹈病的遗传修饰因素
Kevin Correia,Denise Harold,Kyung-Hee Kim et al.
Kevin Correia et al.
Background: Huntington's disease (HD) is a dominantly inherited disease caused by a CAG expansion mutation in HTT. The age at onset of clinical symptoms is determined primarily by the length of this CAG expansion but is a...
Emily Oster,Shirley W Eberly,E Ray Dorsey et al.
Emily Oster et al.
Background: The cohort-level risk of Huntington disease (HD) is related to the age and symptom level of the cohort, but this relationship has not been made precise. ...
Steve Smith,Gibson D&#x;Cruz,Richard Gray et al.
Steve Smith et al.
Background: The complex effects of Huntington's disease (HD) negatively impact on every area of independent living. The perspectives of people impacted by HD on how to best manage the disease are not clearly understood. ...
Practice Effects and Stability of Neuropsychological and UHDRS Tests Over Short Retest Intervals in Huntington Disease [0.03%]
亨廷顿病患者短期内重复进行神经心理学和UHDRS评估的习得效应及量表稳定性研究
Leigh J Beglinger,William H Adams,Jess G Fiedorowicz et al.
Leigh J Beglinger et al.
Background: In Huntington disease (HD), cognitive changes due to disease-progression or treatment are potentially confounded by "practice effects" (PE)--performance improvement from prior exposure to test materials. ...
Randomized Controlled Trial
Journal of Huntington's disease. 2015;4(3):251-60. DOI:10.3233/JHD-150159 2015