Assistive Technology for Cognition and Health-related Quality of Life in Huntington's Disease [0.03%]
亨廷顿舞蹈病的认知辅助技术和与健康相关的生活质量
Marleen R van Walsem,Emilie I Howe,Jan C Frich et al.
Marleen R van Walsem et al.
Background: Assistive technology for cognition (ATC) can be defined as external devices aimed at supporting cognitive function. Studies in neurological populations suggest that use of ATC is a promising strategy to amelio...
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy [0.03%]
基于活体磁共振成像及波谱学的R6/2小鼠外显子大小不同但表型相似的代谢变化规律研究
Stephen J Sawiak,Nigel I Wood,A Jennifer Morton
Stephen J Sawiak
Background: Huntington's disease (HD) is caused by an unstable polyglutamine (CAG) repeat in the HD gene, whereby a CAG repeat length greater than ∼36 leads to the disease. In HD patients, longer repeats correlate with m...
Amit Kumar,Rajiv R Ratan
Amit Kumar
Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a balance between oxidants and antioxidants. This bal...
Therapeutic Effects of Anthocyanins and Environmental Enrichment in R6/1 Huntington's Disease Mice [0.03%]
花青素和环境丰富性对R6/1亨廷顿舞蹈病小鼠的治疗作用
Fabian Kreilaus,Adena S Spiro,Anthony J Hannan et al.
Fabian Kreilaus et al.
Background: Huntington's disease (HD) is a progressive neurodegenerative disease with no effective treatment or cure. Environmental enrichment has been used to slow processes leading to ageing and neurodegenerative diseas...
Induced Pluripotent Stem Cells in Huntington's Disease Research: Progress and Opportunity [0.03%]
诱导性多能干细胞在亨廷顿舞蹈病研究中的进展和前景
Adelaide Tousley,Kimberly B Kegel-Gleason
Adelaide Tousley
Induced pluripotent stem cells (iPSCs) derived from controls and patients can act as a starting point for in vitro differentiation into human brain cells for discovery of novel targets and treatments for human disease without the same ethic...
Health Care Delivery Practices in Huntington's Disease Specialty Clinics: An International Survey [0.03%]
亨廷顿病专科诊所的医疗服务传递模式：一项国际调查
Jan C Frich,Daniela Rae,Richard Roxburgh et al.
Jan C Frich et al.
Background: Little is known about the organization of clinical services for Huntington's disease (HD). Objective: To describe how healt...
Kelly L Andrzejewski,Ariel V Dowling,David Stamler et al.
Kelly L Andrzejewski et al.
Background: The Unified Huntington's Disease Rating Scale (UHDRS) is the principal means of assessing motor impairment in Huntington disease but is subjective and generally limited to in-clinic assessments. ...
Observational Study
Journal of Huntington's disease. 2016 Jun 18;5(2):199-206. DOI:10.3233/JHD-160197 2016
Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice [0.03%]
外源性NUB1在HDQ175/Q7小鼠纹状体内的表达效应
Petr Vodicka,Kathryn Chase,Maria Iuliano et al.
Petr Vodicka et al.
Background: Reducing mutant huntingtin (mHTT) in neurons may be a therapy for Huntington's disease (HD). Elevating NUB1 protein reduced mHTT levels in cell and fly models of HD through a proteasome dependent mechanism. ...
A Longitudinal Motor Characterisation of the HdhQ111 Mouse Model of Huntington's Disease [0.03%]
亨廷顿舞蹈病小鼠模型HdhQ111的纵向电机特征分析
Emma Yhnell,Stephen B Dunnett,Simon P Brooks
Emma Yhnell
Background: Huntington's disease (HD) is a rare, incurable neurodegenerative disorder caused by a CAG trinucleotide expansion with the first exon of the huntingtin gene. Numerous knock-in mouse models are currently availa...
Suicidality in Huntington's Disease: A Qualitative Study on Coping Styles and Support Strategies [0.03%]
亨廷顿病患者的自杀倾向-关于应对方式和支助策略的定性研究
Anna A M Hubers,Annette Hamming,Erik J Giltay et al.
Anna A M Hubers et al.
Background: Huntington's disease (HD) mutation carriers are at increased risk of suicidal ideation, suicide attempts, and completed suicide. However, research is lacking on coping strategies and treatment options that can...