Dysregulation of Corticostriatal Connectivity in Huntington's Disease: A Role for Dopamine Modulation [0.03%]
亨廷顿病中皮质纹状体连接的失调：多巴胺调节的作用
Claudia Rangel-Barajas,George V Rebec
Claudia Rangel-Barajas
Aberrant communication between striatum, the main information processing unit of the basal ganglia, and cerebral cortex plays a critical role in the emergence of Huntington's disease (HD), a fatal monogenetic condition that typically strike...
Important but not Enough - Information about HD Related Topics and Peer and Professional Support for Young Adults from HD Families [0.03%]
重要但不够尽如人意——亨廷顿病相关话题的信息、同龄人及专业人士支持对来自HD家庭的青年人来说意味着什么
Ulrike Braisch,Saul Martinez-Horta,Marcy MacDonald et al.
Ulrike Braisch et al.
Background: The number of people affected by Huntington's disease (HD) is far greater than those with manifest HD because it also includes those at risk, both HD gene mutation carriers and family members not carrying the ...
Plasma Cytokine Levels in Relation to Neuropsychiatric Symptoms and Cognitive Dysfunction in Huntington's disease [0.03%]
亨廷顿病患者的神经精神症状和认知功能障碍与血浆细胞因子水平的关系
Jos A Bouwens,Erik van Duijn,Christa M Cobbaert et al.
Jos A Bouwens et al.
Background: In Huntington's disease (HD) the innate immune system is activated, as reflected by increased plasma levels of different cytokines. Objective:...
Risk Factors for Suicidal Ideation in People at Risk for Huntington's Disease [0.03%]
亨廷顿病高风险人群的自杀意念危险因素分析
Karen E Anderson,Shirley Eberly,Mark Groves et al.
Karen E Anderson et al.
Background: Suicidal ideation (SI) and attempts are increased in Huntington's disease (HD), making risk factor assessment a priority. Objective: ...
Targeting the Cholinergic System to Develop a Novel Therapy for Huntington's Disease [0.03%]
靶向胆碱能系统以开发亨廷顿舞蹈病的新疗法
Gary X D&#x;Souza,Henry J Waldvogel
Gary X D&#x;Souza
In this review, we outline the role of the cholinergic system in Huntington's disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in...
Phenotype Characterization of HD Intermediate Alleles in PREDICT-HD [0.03%]
PREDICT-HD中间型 Huntingtons舞蹈病基因表征研究
Nancy R Downing,Spencer Lourens,Isabella De Soriano et al.
Nancy R Downing et al.
Background: Huntington disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion on chromosome 4. Pathology is associated with CAG repeat length. Prior studies examining people in the intermediate allel...
Multicenter Study
Journal of Huntington's disease. 2016 Dec 15;5(4):357-368. DOI:10.3233/JHD-160185 2016
Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease [0.03%]
亨廷顿舞蹈病小鼠模型中的胚胎突变型猎廷顿蛋白聚集体形成研究
Alexander P Osmand,Terry Jo Bichell,Aaron B Bowman et al.
Alexander P Osmand et al.
The role of aggregate formation in the pathophysiology of Huntington's disease (HD) remains uncertain. However, the temporal appearance of aggregates tends to correlate with the onset of symptoms and the numbers of neuropil aggregates corre...
Comparison of Huntington's disease CAG Repeat Length Stability in Human Motor Cortex and Cingulate Gyrus [0.03%]
人类运动皮质和扣带回Huntington病CAG重复序列长度稳定性比较研究
Fiona C A Geraerts,Russell G Snell,Richard L M Faull et al.
Fiona C A Geraerts et al.
Huntington's disease is caused by expansion of the CAG repeat in Huntingtin. This repeat has shown tissue-specific instability in mouse models and in a small number of post-mortem human samples. We used small-pool PCR to generate a modified...
Cellular Analysis of Silencing the Huntington's Disease Gene Using AAV9 Mediated Delivery of Artificial Micro RNA into the Striatum of Q140/Q140 Mice [0.03%]
AAV9介导的artificial microRNA沉默亨廷顿舞蹈病基因Q140/Q140小鼠纹状体细胞内分析研究
Allison M Keeler,Ellen Sapp,Kathryn Chase et al.
Allison M Keeler et al.
Background: The genetic mutation in Huntington's disease (HD) is a CAG repeat expansion in the coding region of the huntingtin (Htt) gene. RNAi strategies have proven effective in substantially down-regulating Htt mRNA in...
Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice [0.03%]
亨廷顿病Q175小鼠纹状体内转录因子EB（TFEB）的激活诱导自噬
Petr Vodicka,Kathryn Chase,Maria Iuliano et al.
Petr Vodicka et al.
Background: Mutant huntingtin (mHTT) is encoded by the Huntington's disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosoma...