The Effect of Music Therapy in Patients with Huntington's Disease: A Randomized Controlled Trial [0.03%]
赫恩特顿病患者音乐疗法效果的随机对照试验
Monique C H van Bruggen-Rufi,Annemieke C Vink,Ron Wolterbeek et al.
Monique C H van Bruggen-Rufi et al.
Background: Music therapy may have beneficial effects on improving communication and expressive skills in patients with Huntington's disease (HD). Most studies are, however, small observational studies and methodologicall...
Randomized Controlled Trial
Journal of Huntington's disease. 2017;6(1):63-72. DOI:10.3233/JHD-160229 2017
Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion [0.03%]
表达亨廷顿蛋白N17或聚谷氨酰胺及脯氨酸丰富区域缺失版本的敲入小鼠模型的建立与表征
Emily A André,Elise M Braatz,Jeh-Ping Liu et al.
Emily A André et al.
Background: The polyglutamine (polyQ) stretch of the Huntingtin protein (HTT) in mammals is flanked by a highly conserved 17 amino acid N-terminal domain (N17), and a proline-rich region (PRR). The PRR is a binding site f...
Stewarding Hope: The Evolving Landscape of Huntington's Disease Science Communications [0.03%]
守望希望：亨廷顿舞蹈症科学传播的演变景观
George J Yohrling,Louise A Vetter
George J Yohrling
For individuals faced with Huntington's disease (HD), there is no lack of access to information about the newest HD research topics and care trends thanks to social media and online news feeds. Unfortunately, making sense of this volume of ...
Tuyana B Malankhanova,Anastasia A Malakhova,Sergey P Medvedev et al.
Tuyana B Malankhanova et al.
The development of new revolutionary technologies for directed gene editing has made it possible to thoroughly model and study NgAgo human diseases at the cellular and molecular levels. Gene editing tools like ZFN, TALEN, CRISPR-based syste...
Survey of the Huntington's Disease Patient and Caregiver Community Reveals Most Impactful Symptoms and Treatment Needs [0.03%]
亨廷顿病患者及看护者社区调研揭示最具有影响性的症状和治疗需求
Jennifer A Simpson,Debra Lovecky,Jane Kogan et al.
Jennifer A Simpson et al.
Background: In preparation for a meeting with the U.S. Food and Drug Administration (FDA) on Patient-Focused Drug Development in Huntington's disease, the Huntington's Disease Society of America (HDSA) created and distrib...
LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease [0.03%]
HDAC抑制剂LBH589对亨廷顿舞蹈病小鼠模型的神经保护作用
Vanita Chopra,Luisa Quinti,Prarthana Khanna et al.
Vanita Chopra et al.
Background: Modulation of gene transcription by HDAC inhibitors has been shown repeatedly to be neuroprotective in cellular, invertebrate, and rodent models of Huntington's disease (HD). It has been difficult to translate...
Dysregulation of Corticostriatal Connectivity in Huntington's Disease: A Role for Dopamine Modulation [0.03%]
亨廷顿病中皮质纹状体连接的失调：多巴胺调节的作用
Claudia Rangel-Barajas,George V Rebec
Claudia Rangel-Barajas
Aberrant communication between striatum, the main information processing unit of the basal ganglia, and cerebral cortex plays a critical role in the emergence of Huntington's disease (HD), a fatal monogenetic condition that typically strike...
Important but not Enough - Information about HD Related Topics and Peer and Professional Support for Young Adults from HD Families [0.03%]
重要但不够尽如人意——亨廷顿病相关话题的信息、同龄人及专业人士支持对来自HD家庭的青年人来说意味着什么
Ulrike Braisch,Saul Martinez-Horta,Marcy MacDonald et al.
Ulrike Braisch et al.
Background: The number of people affected by Huntington's disease (HD) is far greater than those with manifest HD because it also includes those at risk, both HD gene mutation carriers and family members not carrying the ...
Plasma Cytokine Levels in Relation to Neuropsychiatric Symptoms and Cognitive Dysfunction in Huntington's disease [0.03%]
亨廷顿病患者的神经精神症状和认知功能障碍与血浆细胞因子水平的关系
Jos A Bouwens,Erik van Duijn,Christa M Cobbaert et al.
Jos A Bouwens et al.
Background: In Huntington's disease (HD) the innate immune system is activated, as reflected by increased plasma levels of different cytokines. Objective:...
Risk Factors for Suicidal Ideation in People at Risk for Huntington's Disease [0.03%]
亨廷顿病高风险人群的自杀意念危险因素分析
Karen E Anderson,Shirley Eberly,Mark Groves et al.
Karen E Anderson et al.
Background: Suicidal ideation (SI) and attempts are increased in Huntington's disease (HD), making risk factor assessment a priority. Objective: ...