Elena Bellosta Diago,Saül Martínez-Horta,Sonia Santos Lasaosa et al.
Elena Bellosta Diago et al.
Background: Sleep disturbances are an early and prominent feature of Huntington's disease (HD). Objective: The current study investigat...
Human Immunodeficiency Virus Infection in Huntington's Disease is Associated with an Earlier Age of Symptom Onset [0.03%]
亨廷顿舞蹈病患者的人免疫缺陷病毒感染与症状发作更早有关
Jordan L Schultz,Peg C Nopoulos,Pedro Gonzalez-Alegre
Jordan L Schultz
Background: Huntington Disease (HD) and human immunodeficiency virus (HIV) are both associated with neurodegeneration in the cerebral cortex and striatum. The rate of striatal degeneration is a known predictor of symptom ...
Behavioral Assessment of Stress Compensation in Minipigs Transgenic for the Huntington Gene Using Cortisol Levels: A Proof-of-Concept Study [0.03%]
应激补偿的的行为学评估：用于亨廷顿基因转基因小猪的皮质醇水平测量的概念考证研究
Verena Schuldenzucker,Robin Schubert,Lisa M Muratori et al.
Verena Schuldenzucker et al.
Background: Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disorder with motor, cognitive, behavioral and metabolic symptoms. HD patients exhibit an altered response to stress which is r...
Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models [0.03%]
亨廷顿病敲入小鼠模型中纹状体突变亨廷顿蛋白水平随年龄增长而下降
Nicholas R Franich,Manuela Basso,Emily A André et al.
Nicholas R Franich et al.
Background: Huntington's disease (HD) is a progressive neurodegenerative disorder associated with aging, caused by an expanded polyglutamine (polyQ) repeat within the Huntingtin (HTT) protein. In HD, degeneration of the s...
A Critical Evaluation of Wet Biomarkers for Huntington's Disease: Current Status and Ways Forward [0.03%]
亨廷顿舞蹈病湿式生物标志物批判性评价：现状与展望
Edina Silajdžić,Maria Björkqvist
Edina Silajdžić
There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to su...
Olivia C Roman,Jeffrey Stovall,Daniel O Claassen
Olivia C Roman
Background: Huntington's disease (HD) patients are at significantly higher risk of suicidal behavior, and associated cognitive and behavioral factors play an important role. Impulsivity is commonly thought to be a risk fa...
Carsten Saft,Sarah Maria von Hein,Thomas Lücke et al.
Carsten Saft et al.
Background: Motor symptoms in Huntington's disease (HD) are heterogeneous with dystonia being described as a symptom with a very high prevalence not only in juvenile cases. ...
Genetic Counselling and Narrative Practices: A Model of Support following a "Negative" Predictive Test for Huntington's Disease [0.03%]
基因咨询与叙事实践——亨廷顿舞蹈病“阴性”预测测试后的支持模型
Rhona MacLeod,Ramona Moldovan,Cheryl Stopford et al.
Rhona MacLeod et al.
Background: Predictive testing for Huntington's disease (HD) has been available for individuals at risk of HD by direct mutation analysis since 1993. International Predictive test guidelines recommend that support is offe...
Leslie Thompson,Blair R Leavitt
Leslie Thompson
Filipe B Rodrigues,Edward J Wild
Filipe B Rodrigues
In the second edition of the Huntington’s Disease Clinical Trials Corner we list all currently registered and ongoing clinical trials, summarise the top-line results of the recently-announced IONIS-HTTRX trial (NCT02519036), expand on Wave...