Marriage as Protector for Nursing Home Admission in Huntington's Disease [0.03%]
亨廷顿舞蹈病患者住院治疗的婚姻保护效应分析
Jessica Y Winder,Wilco P Achterberg,Raymund A C Roos
Jessica Y Winder
Background: Huntington's disease is a progressive, incurable neurodegenerative disorder and it is not possible to delay onset or progression of the disease. Consequently, the disease leads to functional decline and loss o...
Vocalisation as a Viable Assessment for Phenotyping Minipigs Transgenic for the Huntington Gene? [0.03%]
转基因亨廷顿基因小猪的行为表型评估的新方法:发声作为行为表型的评价指标
Lorena Rieke,Robin Schubert,Tamara Matheis et al.
Lorena Rieke et al.
Background: Large animal models, such as the transgenic (tg) Huntington disease (HD) minipig, have been proposed to improve translational reliability and assessment of safety, efficacy and tolerability in preclinical stud...
Computational Analysis of Transcriptional Regulation Sites at the HTT Gene Locus [0.03%]
Huntingtin基因位点转录调控区域的计算分析
Rebecca A G De Souza,Natalia Kosior,Sarah B Thomson et al.
Rebecca A G De Souza et al.
Background: Huntington's disease is a late onset neurological disorder caused by a trinucleotide CAG repeat expansion mutation in the HTT gene encoding for the protein huntingtin. Despite considerable ongoing research, th...
Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study [0.03%]
亨廷顿舞蹈病登记队列中癌症发病风险下降现象分析研究
Paul McNulty,Richard Pilcher,Raviram Ramesh et al.
Paul McNulty et al.
Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the rela...
Suicidal Ideation Assessment in Individuals with Premanifest and Manifest Huntington Disease [0.03%]
震颤病前驱期和发作期个体的自杀意念评估
Melissa Wesson,Nicholas R Boileau,Joel S Perlmutter et al.
Melissa Wesson et al.
Background: Huntington disease (HD) is associated with increased risk of suicide. Objective: This study compares suicide ideation in HD...
Multicenter Study
Journal of Huntington's disease. 2018;7(3):239-249. DOI:10.3233/JHD-180299 2018
Clinical Management of Neuropsychiatric Symptoms of Huntington Disease: Expert-Based Consensus Guidelines on Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders [0.03%]
亨廷顿病神经精神症状的临床管理：激越、焦虑、缺乏主动性、精神病和睡眠障碍专家共识指南
Karen E Anderson,Erik van Duijn,David Craufurd et al.
Karen E Anderson et al.
Background: In clinical practice, several strategies and pharmacological options are available to treat neuropsychiatric symptoms of Huntington disease (HD). However, there is currently insufficient data for evidence-base...
Morgane Sonia Thion,Sandrine Humbert
Morgane Sonia Thion
Huntingtin (HTT) is a scaffold protein mostly known because it gives rise to the severe and incurable inherited neurological disorder Huntington's disease (HD) when mutated. The Huntingtin gene (HTT) carries a polymorphic trinucleotide expa...
Anorectal Dysfunction in Presymptomatic Mutation Carriers and Patients with Huntington's Disease [0.03%]
亨廷顿舞蹈病前驱期患者和患者的肛门直肠功能障碍
Jan Kobal,Kolenc Matej,Matic Koželj et al.
Jan Kobal et al.
Background: Huntington's disease (HD) patients often report anorectal dysfunction; however, in HD research no detailed analysis of these complaints has been published. ...
Lindsay Romo,Emily S Mohn,Neil Aronin
Lindsay Romo
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a mutation that expands the polyglutamine (CAG) repeat in exon 1 of the huntingtin (HTT) gene. Wild-type HTT protein interacts with other proteins to protect cel...
Huntington's Disease Outpatient Clinic for Functional Diagnosis and Treatment: Coming to Consensus: How Long Term Care Facility Procedures Complement Specialist Diagnosis and Treatment [0.03%]
亨廷顿舞蹈病专病门诊的功能诊断与治疗：达成共识：长期照护机构的程序如何补充专科医生的诊断和治疗
Ruth Veenhuizen,Hanneke Nijsten,Paul van Roosmalen et al.
Ruth Veenhuizen et al.
Huntington's disease (HD) patients and families deserve expert treatment and care throughout their lives, but uniformity in functional diagnosis and treatment was lacking. In the aim of reaching this uniformity on day-to-day treatment and c...