Cognitive Fitness to Drive in Huntington's Disease: Assessing the Clinical Utility of DriveSafe DriveAware [0.03%]
亨廷顿舞蹈病的认知驾驶能力：评估DriveSafe和DriveAware的临床实用性
Hayden J Farrell,Sophie C Andrews,Nicholas P Ryan et al.
Hayden J Farrell et al.
Background: DriveSafe DriveAware (DSDA) has been validated as an off-road screening tool for predicting on-road driving performance in clinical populations, but its utility in people with Huntington's disease (HD) is unkn...
Contemporary Dance Practice Improves Motor Function and Body Representation in Huntington's Disease: A Pilot Study [0.03%]
当代舞蹈练习改善亨廷顿舞蹈病患者的运动功能和身体表征：一项初步研究
Iris Trinkler,Philippe Chéhère,Julie Salgues et al.
Iris Trinkler et al.
Background: Physical exercise improves neurological conditions, but adherence is hard to establish. Dance might be a promising alternative; however, since patients with Huntington's disease (HD) suffer from rhythmic movem...
Mayke Oosterloo,David Craufurd,Hanneke Nijsten et al.
Mayke Oosterloo et al.
Background: Neuropsychiatric symptoms are highly prevalent in Huntington's disease (HD). However, little is known of the prevalence and course of obsessive-compulsive behaviors (OCBs) and perseverative behaviors (PBs) dur...
Attitudes of Potential Participants Towards Molecular Therapy Trials in Huntington's Disease [0.03%]
亨廷顿舞蹈症分子治疗临床试验潜在参与者的倾向性研究
Tanya M Bardakjian,Kaylee Faulkner Naczi,Pedro Gonzalez-Alegre
Tanya M Bardakjian
Background: Advances in molecular therapeutic approaches in the last decade are translating into the design of non-traditional clinical trials. In order to improve their feasibility, it is important to understand the atti...
Lorena Rieke,Michaela Fels,Robin Schubert et al.
Lorena Rieke et al.
Background: To increase the reliability of translating preclinical findings to humans, large animal models, such as the transgenic (tg) Libechov minipig, were established. As minipigs possess high genetic homology with hu...
Risk Assessment for Huntington's Disease for (Future) Offspring Requires Offering Preconceptional CAG Analysis to Both Partners [0.03%]
huntington舞蹈病的危险评估要求对双方配偶提供妊娠前CAG分析
Aad Tibben,Wybo J Dondorp,Guido M de Wert et al.
Aad Tibben et al.
Amongst the main reasons people at risk for Huntington's disease (HD) have for undergoing predictive genetic testing are planning a family and prevention of passing on an expanded CAG-repeat to future offspring. After having received an unf...
Disease-Modification in Huntington's Disease: Moving Away from a Single-Target Approach [0.03%]
亨廷顿舞蹈病的疾病修饰治疗：从单一靶点策略向多元化策略转变
Melanie P Jensen,Roger A Barker
Melanie P Jensen
To date, no candidate intervention has demonstrated a disease-modifying effect in Huntington's disease, despite promising results in preclinical studies. In this commentary we discuss disease-modifying therapies that have been trialled in H...
Margaret Yu,Kenny Tan,Kimberly Koloms et al.
Margaret Yu et al.
Huntington's disease (HD) is a rare neurodegenerative disease associated with disability and loss of patient independence. The caregivers of HD patients are at high risk for burnout. We aimed to identify variables that impact caregiver burd...
Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease [0.03%]
猎食蛋白可调节Rac1活性并影响亨廷顿舞蹈病模型的病理变化
Adelaide Tousley,Maria Iuliano,Elizabeth Weisman et al.
Adelaide Tousley et al.
Background: Previous studies suggest that Huntingtin, the protein mutated in Huntington's disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes ...
Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Pig Transgenic Model Expressing Human Mutant Huntingtin [0.03%]
骨髓间充质干细胞的成脂分化：猪表达人突变亨廷顿蛋白转基因模型研究
Petra Smatlikova,Stefan Juhas,Jana Juhasova et al.
Petra Smatlikova et al.
Background: Although the highest expression of mutant huntingtin (mtHtt) was observed in the brain, its negative effects were also apparent in other tissues. Specifically, mtHtt impairs metabolic homeostasis and causes tr...