Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington's Disease [0.03%]
诱导多能干细胞来源的亨廷顿舞蹈病患者黑质神经发育缺陷的特征研究
Pranav P Mathkar,Divya Suresh,James Dunn et al.
Pranav P Mathkar et al.
Background: Huntington's disease (HD) is an inherited neurodegenerative disease and is characterized by atrophy of certain regions of the brain in a progressive manner. HD patients experience behavioral changes and uncont...
Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention [0.03%]
亨廷顿病中的糖基化：可能的修饰因素和干预目标
Inês Caldeira Brás,Annekatrin König,Tiago Fleming Outeiro
Inês Caldeira Brás
Glycation is the non-enzymatic reaction between reactive dicarbonyls and amino groups, and gives rise to a variety of different reaction products known as advanced glycation end products (AGEs). Accumulation of AGEs on proteins is inevitabl...
Electroconvulsive Therapy (ECT) for Refractory Psychiatric Symptoms in Huntington's Disease: A Case Series and Review of the Literature [0.03%]
电抽搐治疗亨廷顿病难治性精神症状的病例系列及文献回顾
Jennifer Adrissi,Neil A Nadkarni,Eric Gausche et al.
Jennifer Adrissi et al.
Background: Huntington's disease (HD) is a progressive neurodegenerative disease characterized by involuntary movements and neuropsychiatric decline. With suicide rates five times higher in patients with HD compared to th...
Impact of Huntington's Disease on Mental Rotation Performance in Motor Pre-Symptomatic Individuals [0.03%]
亨廷顿舞蹈病对运动前症状个体心理旋转表现的影响
Shahin Nasr,Herminia D Rosas
Shahin Nasr
Background: Huntington's disease (HD) is a genetic disorder known for affecting motor control. Despite evidence for the impact of HD on visual cortico-striatal loops, evidence for impaired visual perception in early sympt...
Letter in Response to Tibben et al., Risk Assessment for Huntington's Disease for (Future) Offspring Requires Offering Preconceptional CAG Analysis to Both Partners [0.03%]
对蒂布本等关于“ Huntingon舞蹈病风险评估需对双方父母进行孕前CAG分析”的来信的回复
Oliver W Quarrell,Martin B Delatycki,Angus J Clarke et al.
Oliver W Quarrell et al.
A Feasibility Study of Quantitative Motor Assessments in Children Using the Q-Motor Suite [0.03%]
基于Q-Motor量表的儿童定量运动评估的可行性研究
Ellen van der Plas,Robin Schubert,Ralf Reilmann et al.
Ellen van der Plas et al.
Q-Motor is utilized across various clinical trials in adults with Huntington's disease (HD) to provide quantitative, reliable assessments of motor abilities. With gene-knockdown therapies entering the clinic, development of preventative the...
Predicting the Risk of Huntington's Disease with Multiple Longitudinal Biomarkers [0.03%]
基于多种纵向生物标志物预测亨廷顿病的风险
Fan Li,Kan Li,Cai Li et al.
Fan Li et al.
Background: Huntington's disease (HD) has gradually become a public health threat, and there is a growing interest in developing prognostic models to predict the time for HD diagnosis. ...
Observational Study
Journal of Huntington's disease. 2019;8(3):323-332. DOI:10.3233/JHD-190345 2019
Differential Levels and Phosphorylation of Type 1 Inositol 1,4,5-Trisphosphate Receptor in Four Different Murine Models of Huntington Disease [0.03%]
四种亨廷顿舞蹈病小鼠模型中I型IP3受体的差异表达及磷酸化水平
Joakim Iver Post,Trygve B Leergaard,Veronika Ratz et al.
Joakim Iver Post et al.
Background: The intracellular ion channel type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) releases Ca2+ from the endoplasmic reticulum upon stimulation with IP3. Perturbation of IP3R1 has been implicated in the devel...
Jacob Yomtoob,Chen Yeh,Danny Bega
Jacob Yomtoob
Background: Prior Huntington's disease (HD) studies suggest ancillary services improve motor symptoms, cognition, mood, and quality of life but frequency of use and clinicalcharacteristics are unclear. ...
Positive Affect and Well-Being in Huntington's Disease Moderates the Association Between Functional Impairment and HRQOL Outcomes [0.03%]
亨廷顿舞蹈病的正向情绪和幸福感通过功能损害与生活质量的关系作用予以体现
Rebecca E Ready,Nicholas R Boileau,Stacey K Barton et al.
Rebecca E Ready et al.
Background: Positive affect is associated with resiliency and beneficial health outcomes, but little is known about associations between positive affect and health-related quality of life (HRQOL) in Huntington's disease (...