Old foes, new understandings: nuclear entry of small non-enveloped DNA viruses [0.03%]
老对手 新理解：小型无包膜DNA病毒的核内运输机制
Nikta Fay,Nelly Panté
Nikta Fay
The nuclear import of viral genomes is an important step of the infectious cycle for viruses that replicate in the nucleus of their host cells. Although most viruses use the cellular nuclear import machinery or some components of this machi...
Gillian M Air
Gillian M Air
A vaccine formulation that would be effective against all strains of influenza virus has long been a goal of vaccine developers, but antibodies after infection or vaccination were seen to be strain specific and there was little evidence of ...
Karsten Geletneky,Jürg Pf Nüesch,Assia Angelova et al.
Karsten Geletneky et al.
The H-1 parvovirus (H-1PV) exerts oncosuppressive action that has two components: oncotoxicity and immunostimulation. While many human tumor cells, including conventional drug-resistant ones, can be killed by H-1PV, some fail to support pro...
Linling He,Jiang Zhu
Linling He
Rational approaches will be required to develop universal vaccines for viral pathogens such as human immunodeficiency virus, hepatitis C virus, and influenza, for which empirical approaches have failed. The main objective of a rational vacc...
Inbal Sela-Culang,Yanay Ofran,Bjoern Peters
Inbal Sela-Culang
The development of accurate tools for predicting B-cell epitopes is important but difficult. Traditional methods have examined which regions in an antigen are likely binding sites of an antibody. However, it is becoming increasingly clear t...
Luca Bruno,Mirko Cortese,Rino Rappuoli et al.
Luca Bruno et al.
Although almost 15 years have passed since the birthdate of Reverse Vaccinology (RV), there are very limited applications of this approach to viral vaccines discovery. Undeniably, RV presents a series of advantages as it can virtually ident...
Nicholas Glanville,Sebastian L Johnston
Nicholas Glanville
A great burden of disease is attributable to human rhinovirus (HRV) infections which are the major cause of the common cold, exacerbations of both asthma and chronic obstructive pulmonary disease (COPD), and are associated with asthma devel...
Affinity selection of epitope-based vaccines using a bacteriophage virus-like particle platform [0.03%]
基于噬菌体病毒样颗粒平台的表位疫苗亲和选择法
John P O&#x;Rourke,David S Peabody,Bryce Chackerian
John P O&#x;Rourke
Display of epitopes on virus-like particles (VLPs) is a highly effective technique for enhancing the immunogenicity of antigens that are poorly immunogenic in their native context. VLP-based vaccines can be used to elicit long-lasting, high...
Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein [0.03%]
呼吸道合胞病毒融合糖蛋白的中和表位
Jason S McLellan
Jason S McLellan
Respiratory syncytial virus (RSV) is a leading cause of pneumonia and bronchiolitis, but despite decades of research a safe and effective vaccine has remained elusive. The viral fusion glycoprotein (RSV F) plays an obligatory role in the en...
Luca G Guidotti,Matteo Iannacone
Luca G Guidotti