Molecular grappling: the complex interplay involving human herpesviruses, small ubiquitin-like modifier (SUMO), and the host immune system [0.03%]
分子缠斗：人类疱疹病毒、小泛素样修饰物（SUMO）与宿主免疫系统之间的复杂相互作用
Sairam Dasika,Janna M Bigalke
Sairam Dasika
SUMOylation regulates critical cellular processes, including DNA repair, transcription, and immune responses. Human herpesviruses (HHVs) have evolved mechanisms to hijack the SUMO pathway, promoting viral replication, immune evasion, and es...
Kaili Wu,Wenlin Yang,Zhenghe Li
Kaili Wu
Plant rhabdoviruses comprise a group of economically important pathogens that exhibit a complex dual-host infection cycle across plants and insect vectors, relying on exquisitely adapted cross-kingdom infection and survival strategies. In t...
Mass mortality events in aquatic mammals caused by avian influenza viruses [0.03%]
禽流感病毒导致的水生哺乳动物大规模死亡事件
Monica Mirolo,Martin Ludlow,Albert Osterhaus
Monica Mirolo
In recent decades, mass mortality events (MMEs) among aquatic mammals have been caused by morbillivirus or avian influenza virus (AIV) infections. Thus far, AIV infections have been predominantly associated with direct or indirect contact w...
The discovery and development of small molecule immune potentiators (SMIPs) as next-generation vaccine adjuvants, the creation of AS37 [0.03%]
下一代疫苗佐剂的小分子免疫激活剂(SMIPs)的发现和开发及其AS37创制
Elvira Ianni,Daniela Stranges,Derek T O&#x;Hagan
Elvira Ianni
Aluminum salts remain the most widely used adjuvants in licensed vaccines, but their tendency to favor Th2-dominant humoral responses limits their usefulness when robust Th1, T follicular helper (Tfh), and cellular responses are required. S...
Linking vector biology, transmission, and genome architecture in southeastern orthotospoviruses [0.03%]
东南部 Orthotospovirus 的向量生物学、传播和基因组结构之间的联系
Abdelaal Ha Shehata,Edward J Sikora,Amanda Strayer-Scherer et al.
Abdelaal Ha Shehata et al.
Orthotospoviruses remain major threats to specialty and row crops in the southeastern United States through thrips-borne, persistent-propagative transmission. We synthesize the emergence and biology of tomato spotted wilt virus (TSWV) and s...
Nonstandard viral genomes as engines of viral evolution: ecological roles, evolutionary consequences, and insights from mathematical modeling [0.03%]
非标准病毒基因组作为驱动病毒进化的引擎：生态作用、进化结果及数学建模的启示
Santiago F Elena,Julia Hillung,J Tomás Lázaro et al.
Santiago F Elena et al.
Nonstandard viral genomes (nsVGs) are heritable viral genomic forms that differ from the canonical full-length genome through structural rearrangements such as deletions, duplications, copy-back/snap-back structures, or recombination. This ...
Natacha Madelon,Arnaud M Didierlaurent
Natacha Madelon
Combination adjuvants enhance vaccine immunogenicity by integrating multiple immunostimulatory signals that shape both innate and adaptive immune responses. In this review, we summarize the clinical evidence supporting the added value of co...
Suan-Sin Foo,Weiqiang Chen
Suan-Sin Foo
Hera Fatima,Abel Viejo-Borbolla,Thomas Krey
Hera Fatima
The complement system constitutes a powerful antiviral defense, centered on C3b-mediated amplification that drives opsonization, inflammation, and membrane attack complex formation. To persist in the eukaryotic host, viruses must neutralize...
The HEV capsid through a dynamic lens: parallels and divergence from caliciviruses [0.03%]
HEV衣壳的动态模型及其与杯状病毒的异同点
Nachiket Moti,Thomas Peters
Nachiket Moti
The hepatitis E virus (HEV) capsid protein, pORF2, mediates virion assembly, attachment and entry, yet the molecular mechanisms underlying these processes remain poorly defined. Structural studies have provided high-resolution views of pORF...