Michael Gale Jr,Curt M Horvath
Michael Gale Jr
Editorial overview: Preventive and therapeutic vaccines (B cell epitope vaccine) [0.03%]
评论概述：预防性和治疗性疫苗（B细胞表位疫苗）
Mansun Law
Mansun Law
Influence of antibodies and T cells on dengue disease outcome: insights from interferon receptor-deficient mouse models [0.03%]
抗体和T细胞对登革热疾病结果的影响：来自干扰素受体缺陷小鼠模型的启示
William W Tang,Rajvir Grewal,Sujan Shresta
William W Tang
Dengue virus (DENV) is a globally important mosquito-borne virus that causes a spectrum of diseases ranging from dengue fever (DF) to dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), affecting 3.6 billion people in 128 countries [1...
James Burke,Jorge Nieva,Mitesh J Borad et al.
James Burke et al.
Developing a live anti-cancer agent derived in most cases from human pathogens presents a unique set of challenges to clinical development versus those anticipated with standard chemotherapeutics and small molecules. The selection of therap...
Xinzheng Zhang,Lei Sun,Michael G Rossmann
Xinzheng Zhang
Dengue virus is the causative agent of dengue virus fever. It infects about 400 million people per year and leads to about 21,000 deaths annually. There is available neither a fully successful vaccine nor a successful drug therapy. Some den...
Viral elements and host cellular proteins in intercellular movement of Bamboo mosaic virus [0.03%]
竹花叶病毒细胞间运动中的病毒组分和宿主细胞蛋白
Ming-Ru Liou,Chung-Chi Hu,Yuan-Lin Chou et al.
Ming-Ru Liou et al.
As a member of the genus Potexvirus, Bamboo mosaic virus (BaMV) also belongs to the plant viruses that encode triple gene block proteins (TGBps) for intercellular movement within the host plants. Recent studies of the movement mechanisms of...
Bin Wu,Sun Hur
Bin Wu
RIG-I and MDA5 are well-conserved cytoplasmic pattern recognition receptors that detect viral RNAs during infection and activate the type I interferon (IFN)-mediated antiviral immune response. While much is known about how these receptors r...
Capitalizing on knowledge of hepatitis C virus neutralizing epitopes for rational vaccine design [0.03%]
利用对丙型肝炎病毒中和表位的认识理性设计疫苗
Leopold Kong,Kelli N Jackson,Ian A Wilson et al.
Leopold Kong et al.
Hepatitis C virus infects nearly 3% of the world's population and is often referred as a silent epidemic. It is a leading cause of liver cirrhosis and hepatocellular carcinoma in endemic countries. Although antiviral drugs are now available...
Paul Bg van Erp,Gary Bloomer,Royce Wilkinson et al.
Paul Bg van Erp et al.
The interface between viruses and their hosts' are hot spots for biological and biotechnological innovation. Bacteria use restriction endonucleases to destroy invading DNA, and industry has exploited these enzymes for molecular cut-and-past...
Nicole A Doria-Rose,M Gordon Joyce
Nicole A Doria-Rose
Antibodies with protective activity are critical for vaccine efficacy. Affinity maturation increases antibody activity through multiple rounds of somatic hypermutation and selection in the germinal center. Identification of HIV-1 specific a...