Editorial overview: The lung, the gut, and the genital mucosae: microbial targets and therapeutic playgrounds [0.03%]
主编按语：肺、肠和生殖黏膜：微生物靶点与治疗 playgrounds
Jean-Michel Sallenave,Zhou Xing
Jean-Michel Sallenave
Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals [0.03%]
丙型肝炎病毒与肝细胞癌：直接抗病毒药物时代的致癌作用
Felix Fiehn,Claudia Beisel,Marco Binder
Felix Fiehn
Chronic hepatitis C virus (HCV) infection is a major cause of hepatic fibrosis and cirrhosis, with a risk for the development of hepatocellular carcinoma (HCC). Although highly effective direct-acting antivirals (DAAs) are available, the in...
Luca D Bertzbach,Wing-Hang Ip,Konstantin von Stromberg et al.
Luca D Bertzbach et al.
Oncogenic viruses contribute to 15% of global human cancers. To achieve that, virus-encoded oncoproteins deregulate cellular transcription, antagonize common cellular pathways, and thus drive cell transformation. Notably, adenoviruses were ...
Role of mucosal-associated invariant T cells in coronavirus disease 2019 vaccine immunogenicity [0.03%]
黏膜相关不变T细胞在新型冠状病毒疾病2019疫苗免疫原性中的作用
Ali Amini,Paul Klenerman,Nicholas M Provine
Ali Amini
Mucosal-associated invariant T (MAIT) cells are an unconventional T cell population that are highly abundant in humans. They possess a semi-invariant T cell receptor (TCR) that recognises microbial metabolites formed during riboflavin biosy...
Role of the intestinal microbiota in host defense against respiratory viral infections [0.03%]
肠道微生物群在宿主防御呼吸道病毒感染中的作用
Idia Boncheva,Johanne Poudrier,Emilia L Falcone
Idia Boncheva
Viral infections, including those affecting the respiratory tract, can alter the composition of the intestinal microbiota, which, in turn, can significantly influence both innate and adaptive immune responses, resulting in either enhanced p...
Delphine Bonhomme,Enzo Z Poirier
Delphine Bonhomme
Virus infection activates specific pattern recognition receptors and immune signal transduction, resulting in pro-inflammatory cytokine production and activation of innate immunity. We describe here the molecular organization of early signa...
Elena Stylianou,Iman Satti
Elena Stylianou
Bacille Calmette-Guérin (BCG) remains the sole licensed vaccine against tuberculosis (TB), despite its variable efficacy in protecting against pulmonary TB. The development of effective TB vaccines faces significant challenges, marked by t...
Journey of monocytes and macrophages upon influenza A virus infection [0.03%]
甲型流感病毒感染中的单核细胞和巨噬细胞的分化迁移路径
Cecilia Ruscitti,Coraline Radermecker,Thomas Marichal
Cecilia Ruscitti
Influenza A virus (IAV) infections pose a global health challenge that necessitates a comprehensive understanding of the host immune response to devise effective therapeutic interventions. As monocytes and macrophages play crucial roles in ...
A complex immune communication between eicosanoids and pulmonary macrophages [0.03%]
白细胞介素与肺巨噬细胞之间的复杂免疫通信
Erwan Pernet,Jeremie Poschmann,Maziar Divangahi
Erwan Pernet
Respiratory viral infections represent a constant threat for human health and urge for a better understanding of the pulmonary immune response to prevent disease severity. Macrophages are at the center of pulmonary immunity, where they play...
Mechanisms of mucosal immunity at the female reproductive tract involved in defense against HIV infection [0.03%]
女性生殖道中参与防御HIV感染的粘膜免疫机制
Margaret Wy Choi,Carmina A Isidoro,Amy Gillgrass
Margaret Wy Choi
Human immunodeficiency virus-1 remains a major global health threat. Since the virus is often transmitted through sexual intercourse and women account for the majority of new infections within the most endemic regions, research on mucosal i...