Robert S Coffin
Robert S Coffin
Viruses have been suggested to be useful as anti-cancer agents since the early 20th century, although following the advent of chemotherapy and radiotherapy work largely stopped until the 1990s when a number of groups began to explore the us...
Lindsey B Crawford,Daniel N Streblow,Morgan Hakki et al.
Lindsey B Crawford et al.
The generation of humanized mouse models in which immune deficient mice are engrafted with human tissues allows for the direct in vivo investigation of human-restricted viruses. These humanized mouse models have been developed and improved ...
HIV-1 genotypic drug resistance testing: digging deep, reaching wide? [0.03%]
人免疫缺陷病毒(HIV-1)基因型药物耐药检测：深入挖掘,广泛覆盖？
Kristel Van Laethem,Kristof Theys,Anne-Mieke Vandamme
Kristel Van Laethem
For many years, population-based Sanger sequencing has been the golden standard for drug resistance testing within the routine follow-up of HIV-1 infected patients in resource-rich settings. Often, the data generated within this framework w...
Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus [0.03%]
重组瘤内多萝病毒的细胞毒性和免疫原性机制研究
Michael C Brown,Matthias Gromeier
Michael C Brown
An oncolytic virus (OV) based on poliovirus (PV), the highly attenuated polio/rhinovirus recombinant PVSRIPO, may deliver targeted inflammatory cancer cell killing; a principle that is showing promise in clinical trials for recurrent gliobl...
Marshall E Karpel,Christian L Boutwell,Todd M Allen
Marshall E Karpel
Humanized mice are valuable models for the research and development of vaccine strategies and therapeutic interventions to control or eradicate HIV. The BLT humanized mouse model is particularly promising because the combination of transpla...
Host genes and influenza pathogenesis in humans: an emerging paradigm [0.03%]
人类宿主基因与流感发病机制：一个新兴的理论体系
Kelvin Kai-Wang To,Jie Zhou,Jasper Fuk-Woo Chan et al.
Kelvin Kai-Wang To et al.
The emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underl...
Genetic polymorphisms and HPV infection in oral squamous cell carcinomas [0.03%]
口腔鳞状细胞癌中的遗传多态性和HPV感染
Yan Sun,Yang Zhang,Limei Liu et al.
Yan Sun et al.
Despite declining smoking rates in the United States, the incidence of oral squamous cell carcinomas (OSCC, including oral cavity and oropharynx) is rising in young adults. The reasons have been attributed to changes in sexual behaviors and...
Relating structure and function of viral membrane-spanning miniproteins [0.03%]
描述病毒跨膜小蛋白质的结构与功能之间的关系
Stanley J Opella
Stanley J Opella
Many viruses express small hydrophobic membrane proteins. These proteins are often referred to as viroporins because they exhibit ion channel activity. However, the channel activity has not been definitively associated with a biological fun...
Eric Jan,Yizhi Jane Tao
Eric Jan
Gloria Lozano,Encarnación Martínez-Salas
Gloria Lozano
A diverse group of viruses subvert the host translational machinery to promote viral genome translation. This process often involves altering canonical translation initiation factors to repress cellular protein synthesis while viral protein...