Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM [0.03%]
利用原位冷冻电镜揭示RNA病毒复制中的可成药暗物质
Himanshu Sharma,Marie N Sorin,Kiran B Sharma et al.
Himanshu Sharma et al.
Viral proteins typically exist in the context of complex virions or in the even more complex host cells in which they replicate. Hence, meaningful insights into virus protein structure often need to account for this context. Various flavors...
Editorial overview: Viruses and cancer - challenges, breakthroughs, and future directions [0.03%]
主编按语：病毒与癌症——挑战、突破和未来方向
Luca D Bertzbach,Nicole Fischer,Benedikt B Kaufer
Luca D Bertzbach
State-of-the-art in oncolytic virotherapy using adenoviruses other than the commonly applied adenovirus type 5 [0.03%]
腺病毒型五以外的溶瘤病毒疗法研究进展综述
Katrin Schröer,Lotta Fiege,Alina Wolf et al.
Katrin Schröer et al.
In most clinical trials, oncolytic viruses (OAds) based on human adenovirus type 5 (HAdV-C5) were explored, and only rarely a complete switch to another adenovirus type was evaluated. This review highlights the broader diversity of human ad...
Molecules to spillover: how climate warming impacts mosquito-borne viruses [0.03%]
从分子到溢出：气候变暖如何影响蚊媒病毒
Isabel O Delwel,Erin A Mordecai
Isabel O Delwel
Climate change is a critical driver in the outbreaks of vector-borne infectious diseases worldwide. Arbovirus vectors, namely, mosquitoes, exhibit strong and nonlinear responses to climatic factors, such as temperature driving changes in in...
Esther Föderl-Höbenreich,Katrin Panzitt
Esther Föderl-Höbenreich
Ex vivo liver culture models, particularly three-dimensional (3D) models, are vital for studying viral infections of the liver, as they replicate the complex microenvironment more accurately than traditional two-dimensional cultures. These ...
Alexandre Lalande,Lola Canus,Amélie Bourgeais et al.
Alexandre Lalande et al.
To model infection of viruses targeting the liver and the central nervous system, two-dimensional in vitro cultures rapidly show their limitations. Conversely, in vivo models do not easily allow the investigation of early events of the infe...
Recent advances in animal models of lymphomagenesis caused by human γ-herpesviruses [0.03%]
由人类γ-疱疹病毒引起的淋巴瘤动物模型的近期进展
Christian Münz
Christian Münz
The two human γ-herpesviruses Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) cause around 2-3% of all cancers in man. Their exclusive tropism for humans and associated lack of small animal models has impeded the ...
Charlène Martin,Mathilde Bergamelli,Hélène Martin et al.
Charlène Martin et al.
Viral infections during pregnancy represent a major threat to maternal, fetal, and neonatal health outcome, with a high risk of vertical transmission. It is therefore crucial to understand the mechanisms underlying the interaction between v...
Human brain tissue cultures: a unique ex vivo model to unravel the pathogenesis of neurotropic arboviruses [0.03%]
人类脑组织培养物：一种解开嗜神经性虫媒病毒发病机制的体外模型
Glaucia M Almeida,Bruna M Silva,Eurico Arruda et al.
Glaucia M Almeida et al.
Arboviruses are transmitted by arthropods, and their spread from endemic to nonendemic regions has been accelerated by deforestation, climate change, and global mobility. Arbovirus infection in human results in symptoms ranging from mild to...
In vitro modeling of influenza infection in the respiratory epithelium: advanced cellular models to better understand complex host-virus interactions [0.03%]
呼吸道上皮中流感感染的体外模型：更好的复杂宿主-病毒相互作用细胞模型
Aurélien Gibeaud,Andrés Pizzorno,Olivier Terrier
Aurélien Gibeaud
Influenza viruses pose significant global health threats, causing widespread morbidity and mortality due to their genetic variability and rapid evolution. Traditional experimental models, such as immortalized cell lines and animal models, o...