Human brain tissue cultures: a unique ex vivo model to unravel the pathogenesis of neurotropic arboviruses [0.03%]
人类脑组织培养物：一种解开嗜神经性虫媒病毒发病机制的体外模型
Glaucia M Almeida,Bruna M Silva,Eurico Arruda et al.
Glaucia M Almeida et al.
Arboviruses are transmitted by arthropods, and their spread from endemic to nonendemic regions has been accelerated by deforestation, climate change, and global mobility. Arbovirus infection in human results in symptoms ranging from mild to...
In vitro modeling of influenza infection in the respiratory epithelium: advanced cellular models to better understand complex host-virus interactions [0.03%]
呼吸道上皮中流感感染的体外模型：更好的复杂宿主-病毒相互作用细胞模型
Aurélien Gibeaud,Andrés Pizzorno,Olivier Terrier
Aurélien Gibeaud
Influenza viruses pose significant global health threats, causing widespread morbidity and mortality due to their genetic variability and rapid evolution. Traditional experimental models, such as immortalized cell lines and animal models, o...
Jil A Haase,Sarah Schlienkamp,Julian J Ring et al.
Jil A Haase et al.
Hepatitis E virus (HEV) causes sporadic cases in industrialized countries and endemic outbreaks in areas with lower sanitation standards. The wide host reservoir of HEV makes it a potential source of new zoonotic transmission and disseminat...
Hao Li,Chih-Ying Lee,Henri-Jacques Delecluse
Hao Li
Epidemiological studies have provided strong evidence that Epstein-Barr virus (EBV) lytic replication is linked to cancer development. Evidence of abortive lytic replication in some tumors and infections with recombinant viruses incapable o...
Blood virome research in myalgic encephalomyelitis/chronic fatigue syndrome: challenges and opportunities [0.03%]
肌痛性脑脊髓炎/慢性疲劳综合征中的血液病毒组研究：挑战与机遇
Dominic Obraitis,Dawei Li
Dominic Obraitis
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with a complex clinical presentation and an unknown etiology. Various viral infections have been proposed as potential triggers of ME/CFS onset, but no sp...
Host-pathogen interactions of emerging zoonotic viruses: bats, humans and filoviruses [0.03%]
新出现的人畜共患病毒的宿主-病原体相互作用：蝙蝠、人类和丝状病毒
Grace Hood,Miles Carroll
Grace Hood
This paper provides an overview of the phenomena of cross-species transmission of viruses (known as spillover), focusing on the highly pathogenic filovirus family and their natural reservoir: bats. It also describes the host-pathogen relati...
Advancing zoonotic respiratory virus research through the use of organoids [0.03%]
通过使用类器官来推进人畜共患呼吸道病毒的研究
Meaghan Flagg,Emmie de Wit
Meaghan Flagg
Zoonotic viruses with the ability to replicate in the human respiratory tract pose a threat to public health. Organoids, which are highly representative, multicellular models representing specific organs or tissues, can aid in our understan...
Rachael Tarlinton,Alex D Greenwood
Rachael Tarlinton
The koala retrovirus, KoRV, is one of the few models for understanding the health consequences of retroviral colonization of the germline. Such colonization events transition exogenous infectious retroviruses to Mendelian traits or endogeno...
Seth D Judson,David W Dowdy
Seth D Judson
The 2013-2016 Ebola virus disease epidemic and the coronavirus disease 2019 pandemic galvanized tremendous growth in models for emerging zoonotic and vector-borne viruses. Therefore, we have reviewed the main goals and methods of models to ...
Hafiz S Zafar,Haji Akbar,Huai Xu et al.
Hafiz S Zafar et al.
Oncogenic viruses play a pivotal role in oncology due to their unique role in unraveling the complexities of cancer development. Understanding the role viruses play in specific cancers is important to provide basic insights into the transfo...