Status of advanced respiratory syncytial virus antiviral therapeutics 2025 [0.03%]
2025年呼吸道合胞病毒感染的先进抗病毒治疗药物现状
Claire E Ruckel,Josef D Wolf,Richard K Plemper
Claire E Ruckel
Respiratory syncytial virus (RSV) causes major morbidity and mortality in vulnerable populations. In infants, RSV infection is a leading cause of hospitalization and can result to severe respiratory complications marked by bronchiolitis and...
Human organoid models to study coronavirus infections of the respiratory tract [0.03%]
人源器官模型研究呼吸道冠状病毒感染
Merel R Te Marvelde,Laura LA van Dijk,Mark A Power et al.
Merel R Te Marvelde et al.
The coronavirus disease 2019 (COVID-19) pandemic emphasized the need to study coronaviruses more thoroughly. Next to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), humans can be infected by SARS-CoV, Middle East respiratory s...
Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM [0.03%]
利用原位冷冻电镜揭示RNA病毒复制中的可成药暗物质
Himanshu Sharma,Marie N Sorin,Kiran B Sharma et al.
Himanshu Sharma et al.
Viral proteins typically exist in the context of complex virions or in the even more complex host cells in which they replicate. Hence, meaningful insights into virus protein structure often need to account for this context. Various flavors...
Editorial overview: Viruses and cancer - challenges, breakthroughs, and future directions [0.03%]
主编按语：病毒与癌症——挑战、突破和未来方向
Luca D Bertzbach,Nicole Fischer,Benedikt B Kaufer
Luca D Bertzbach
State-of-the-art in oncolytic virotherapy using adenoviruses other than the commonly applied adenovirus type 5 [0.03%]
腺病毒型五以外的溶瘤病毒疗法研究进展综述
Katrin Schröer,Lotta Fiege,Alina Wolf et al.
Katrin Schröer et al.
In most clinical trials, oncolytic viruses (OAds) based on human adenovirus type 5 (HAdV-C5) were explored, and only rarely a complete switch to another adenovirus type was evaluated. This review highlights the broader diversity of human ad...
Molecules to spillover: how climate warming impacts mosquito-borne viruses [0.03%]
从分子到溢出：气候变暖如何影响蚊媒病毒
Isabel O Delwel,Erin A Mordecai
Isabel O Delwel
Climate change is a critical driver in the outbreaks of vector-borne infectious diseases worldwide. Arbovirus vectors, namely, mosquitoes, exhibit strong and nonlinear responses to climatic factors, such as temperature driving changes in in...
Esther Föderl-Höbenreich,Katrin Panzitt
Esther Föderl-Höbenreich
Ex vivo liver culture models, particularly three-dimensional (3D) models, are vital for studying viral infections of the liver, as they replicate the complex microenvironment more accurately than traditional two-dimensional cultures. These ...
Alexandre Lalande,Lola Canus,Amélie Bourgeais et al.
Alexandre Lalande et al.
To model infection of viruses targeting the liver and the central nervous system, two-dimensional in vitro cultures rapidly show their limitations. Conversely, in vivo models do not easily allow the investigation of early events of the infe...
Recent advances in animal models of lymphomagenesis caused by human γ-herpesviruses [0.03%]
由人类γ-疱疹病毒引起的淋巴瘤动物模型的近期进展
Christian Münz
Christian Münz
The two human γ-herpesviruses Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) cause around 2-3% of all cancers in man. Their exclusive tropism for humans and associated lack of small animal models has impeded the ...
Charlène Martin,Mathilde Bergamelli,Hélène Martin et al.
Charlène Martin et al.
Viral infections during pregnancy represent a major threat to maternal, fetal, and neonatal health outcome, with a high risk of vertical transmission. It is therefore crucial to understand the mechanisms underlying the interaction between v...