Host-targeted antivirals as broad-spectrum inhibitors of respiratory viruses [0.03%]
针对宿主的抗病毒药物可作为广谱呼吸道病毒抑制剂
Rudolf K Beran,Arya Vijjapurapu,Varsha Nair et al.
Rudolf K Beran et al.
Respiratory viruses, including influenza virus, respiratory syncytial virus, human rhinovirus, and severe acute respiratory syndrome coronavirus 2, are among the leading causes of acute respiratory infections worldwide. Strategies for antiv...
Multiple roles of the matrix protein Z in arenavirus infection - a structural perspective [0.03%]
.arenavirus感染中矩阵蛋白Z的多种作用——结构视角
Annika Rammelt,Saskia Johanns,Lennart Sänger et al.
Annika Rammelt et al.
Arenaviridae (class of Bunyaviricetes) are a group of negative-sense single-stranded RNA viruses. They can cause severe human disease after zoonotic spillover from mostly rodent reservoirs, with no approved vaccines or antiviral treatments ...
Virological and immunological determinants of hepatitis E virus infection outcomes [0.03%]
HE病毒感染结局的病毒学和免疫学决定因素
Xinjia Wang,Lu Bian,Eun Hee Ha et al.
Xinjia Wang et al.
Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide, especially in regions with limited sanitation infrastructure. Unlike hepatitis B virus (HBV) and hepatitis C virus (HCV) - which frequently progress to chronic i...
Sequence variability of the K1 gene in Kaposi's sarcoma-associated herpesvirus and its role in pathogenesis [0.03%]
卡波西肉瘤相关疱疹病毒K1基因的序列多态性及其在发病机制中的作用
Soyoung Choi,Jun Tae Song,Seung-Hyun Lee et al.
Soyoung Choi et al.
Infectious pathogens account for approximately 13% of all human cancers globally, with oncogenic viruses constituting the majority. Among them, Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus, remains a persistent public ...
The Dengue NS1 epitope landscape: a blueprint for next-generation vaccines and therapeutics [0.03%]
登革病毒NS1表位图谱：下一代疫苗和治疗药物的蓝图
Romchat Kraivong,Sararat Hattakam,Somchai Thiemmeca et al.
Romchat Kraivong et al.
The dengue virus (DENV) nonstructural protein 1 (NS1) is a critical 'double-edged sword' in dengue pathogenesis and immunity. While a key driver of vascular pathology, it is also a major target for protective immune responses that lack the ...
Intercellular highways of viral spread: tunneling nanotubes and extracellular vesicles at the maternal-fetal interface [0.03%]
细胞间病毒传播的高速公路：母胎界面的穿孔纳米管和胞外囊泡
Long B Tran,Rafael T Michita,Deepak Kumar et al.
Long B Tran et al.
The placenta serves as both a conduit and a barrier, facilitating nutrient exchange while shielding the fetus from pathogens. Despite these defenses, several viruses, including ZIKV, CMV, HSV, HIV, LCMV, and HBV, can breach the placental ba...
Nexus of virus and brain: recent advances in flavivirus and enterovirus neuro-infection [0.03%]
病毒与中枢神经系统的关系：黄病毒和肠道病毒中枢神经感染的最新研究进展
Cheryl Yi-Pin Lee,Fok-Moon Lum
Cheryl Yi-Pin Lee
The global prevalence of neurotropic viruses is increasing annually, with no effective treatments available. Viral entry into the brain involves a complex interplay of host and viral factors, such as tight junction complexes, immune regulat...
Intracranial calcifications in congenital viral infections: mechanisms and cellular roles [0.03%]
先天性病毒感染的颅内钙化：机制和细胞作用
Michael Fraczek,Haley Breckenridge,Ivonne Melano et al.
Michael Fraczek et al.
Intracranial calcifications (ICCs) are a characteristic neuropathological feature of several congenital viral infections, including Zika virus (ZIKV), cytomegalovirus (CMV), and lymphocytic choriomeningitis virus (LCMV). These lesions are l...
Human T-cell leukemia virus type I: modulation of viral gene expression and perturbation of host signaling pathways lead to persistent infection [0.03%]
人类T细胞白血病病毒I型：病毒感染的持续性及其对宿主信号途径和病毒基因表达的调节作用
Takafumi Shichijo,Jun-Ichirou Yasunaga
Takafumi Shichijo
Human T-cell leukemia virus type I (HTLV-1) was the first human pathogenic retrovirus to be discovered. HTLV-1 induces a T-cell malignancy, adult T-cell leukemia-lymphoma (ATL), and inflammatory diseases, such as HTLV-1-associated myelopath...
Applications and limitations of respiratory virus infection models in well-differentiated airway epithelial cell cultures of livestock [0.03%]
家畜分化气道上皮细胞培养中呼吸道病毒模型的应用和限制因素
Nora M Gerhards,Luca Bordes,Manouk Vrieling et al.
Nora M Gerhards et al.
Development of multispecies well-differentiated airway epithelial cell (WD-AEC) models derived from either primary cells or airway organoids has led to novel options for in vitro characterization of host-pathogen interactions for viruses as...