Human autoantibodies against type I interferons in severe viral disease [0.03%]
重症病毒性疾病中的自身抗体对抗I型干扰素
Kevin Groen,Benjamin G Hale
Kevin Groen
Type I interferons (IFN-Is) are critical antiviral cytokines that restrict viral replication and limit viral disease. A remarkable recent discovery is that human autoantibodies (autoAbs) neutralizing the activities of IFN-Is phenocopy inbor...
Juwan Kim,Su J Lee,Dae-Gyun Ahn et al.
Juwan Kim et al.
Zoonotic viruses pose an escalating threat to global health, driven by climate change, deforestation, urbanization, and increased human-wildlife interactions. Among these threats, Henipaviruses - particularly Hendra virus and Nipah virus - ...
Sarah Schlienkamp,Olinda Pinto Veiga,Volker Kinast et al.
Sarah Schlienkamp et al.
Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis, yet the virus has been associated with extrahepatic complications, including neurological and renal disorders. These extrahepatic manifestations pose challenges for the di...
Re-emerging Oropouche virus infections: insights into maternal-fetal crosstalk, coinfections, and expanding public health threats [0.03%]
再度出现的Oropouche病毒感染：母胎交互作用、合并感染及公共卫生威胁的见解
Débora Familiar-Macedo,Gielenny M Salem,Anushka Kesavan et al.
Débora Familiar-Macedo et al.
Oropouche virus (OROV), a re-emerging orthobunyavirus of the Simbu serogroup, is increasingly recognized as a significant arboviral threat across the Americas. Although historically underrecognized, OROV infection raises urgent concerns due...
Shi-Yang Tian,Xin Wu
Shi-Yang Tian
Co-infection of Brucella and viruses represents an emerging clinical and epidemiological challenge. Recent evidence reveals that Brucella-viral co-infections are characterized by atypical clinical manifestations and increased diagnostic com...
A storm is born: immune activation and pathogenesis in arthritogenic alphavirus infections [0.03%]
烈风初现：关节炎致病性α病毒的免疫激活及发病机制
Wesley Freppel,Yong Qian Koo,Lara J Herrero
Wesley Freppel
Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, and Mayaro viruses, are emerging global viruses responsible for causing arthralgia and chronic arthritis. Following mosquito-borne transmission, they quickly initiate in...
A novel antiviral strategy by disrupting the equilibrium of virus-host calcium homeostasis [0.03%]
通过破坏病毒-宿主细胞钙稳态平衡以抑制多种病毒感染的新策略
Erwan Brémaud,Belinda L Spillings,Johnson Mak
Erwan Brémaud
Calcium (Ca2+) homeostasis is essential for cellular signaling and protein trafficking. Viruses are comparatively simple organisms that leverage the availability of host cellular mechanisms for viral replication, including the manipulation ...
New directions in the multifunctionality of RNA viruses: insights from the rabies virus P-protein [0.03%]
RNA病毒多功能性新进展——来源于狂犬病病毒P蛋白的启示
Hudson A Smith,Shatabdi Chakraborty,Paul R Gooley et al.
Hudson A Smith et al.
RNA viruses have compact genomes that typically encode only a few proteins, but these viruses orchestrate complex replication cycles while concurrently exercising control over multiple aspects of the biology of the infected host cell, inclu...
Severe fever with thrombocytopenia syndrome virus NSs: a multifaceted viral protein in host-virus interactions [0.03%]
塞卡病毒NSs蛋白在宿主-病毒相互作用中的多面性
Kabita Adhikari,Younho Choi
Kabita Adhikari
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly lethal tick-borne bunyavirus, and its nonstructural protein NSs is the engine driving viral pathogenesis. Far beyond a simple accessory protein, NSs acts as a master mani...
Evaluating the zoonotic spectrum of sandfly-borne phleboviruses, Africa [0.03%]
评估非洲沙蝇传播的虫媒菲沃病毒的动物宿主范围
Edwin O Ogola,Missiani Ochwoto,Tatenda Chiuya et al.
Edwin O Ogola et al.
Sandfly-borne phleboviruses (SBPs) are an important cause of febrile diseases and neuroinvasive infections in humans, especially in endemic regions. They have been described in Central Asia, Africa, the Middle East, and the Mediterranean re...