Samuel Donaire-Carpio,Adam Moundib,Chloë Delon et al.
Samuel Donaire-Carpio et al.
Orthoflaviviruses, a genus of RNA viruses transmitted primarily by arthropods, exhibit remarkable adaptability, infecting a broad range of hosts, from insects to vertebrates, despite their compact ∼11-kilobase genome. To maximize their fun...
Programming systemic and mucosal immunity through co-adjuvant-based prime-boost vaccination [0.03%]
基于协同免疫佐剂的免疫接种编程系统免疫和粘膜免疫
Satoshi Uematsu
Satoshi Uematsu
The development of effective mucosal vaccines has been limited by the limited availability of mucosal adjuvant approaches with established clinical track records and an incomplete understanding of how systemic and mucosal immunity are coord...
Johnson Mak,John P Bilello
Johnson Mak
Qilin Xin,Pierre-Yves Lozach
Qilin Xin
Orthobunyaviruses (OBVs) are medically and veterinary important arboviruses with simple genomes yet complex entry mechanisms enabling infection of diverse mammalian hosts. Understanding of the molecular and cellular processes mediating OBV ...
Antiviral restriction factors of bats: the front line of a critical reservoir of zoonotic viruses [0.03%]
蝙蝠的抗病毒限制因子：人畜共患病病毒的关键宿主的前沿阵地
Joshua A Hayward,Michelle L Baker,Gilda Tachedjian
Joshua A Hayward
Bats harbor diverse viruses pathogenic in other mammals, typically without obvious signs of clinical disease, attributed to an immune system that balances antiviral immunity with disease tolerance. It has been hypothesized that this balance...
Bridging the gap: ex vivo human skin explants for mechanistic studies of arboviruses [0.03%]
体外人皮肤移植片在虫媒病毒发病机制研究中的应用桥梁：体外人皮肤移植片在虫媒病毒发病机制研究中的作用
Fanny Hellhammer,Gisa Gerold,Stefanie Christine Becker
Fanny Hellhammer
Arboviruses such as dengue (DENV), Zika (ZIKV), chikungunya virus (CHIKV), and Crimean-Congo hemorrhagic fever (CCHFV) have been extensively studied in cell culture and animal models, yet how these findings translate to early infection even...
Maya I Rhyn,Angela Castellano,Valeria Cortesi et al.
Maya I Rhyn et al.
Viral infection-related hospitalization and mortality rates are highest in human newborns and infants compared to older children and adults, suggesting age-specific vulnerability and a non-redundant role for the maternal immune system. Howe...
Ancestral FUT2 genetic adaptation confers resistance to modern norovirus and rotavirus infections [0.03%]
祖先FUT2基因组适应性对现代诺如病毒和轮状病毒感染具有抵抗作用
Johan Nordgren,Richard Ågren,Marie Hagbom et al.
Johan Nordgren et al.
Human genetic diversity plays a key role in modulating susceptibility to infectious diseases, reflecting a long history of host-pathogen co-evolution. While clinical outcomes were once attributed primarily to pathogen virulence, evidence to...
Phoebe Hazenberg,Christopher Ja Duncan
Phoebe Hazenberg
Alongside the development of antibiotics, vaccination is the medical innovation with arguably the greatest impact on human health. Testament to its success is the eradication of infectious diseases, such as smallpox, that devastated human p...
Trine H Mogensen
Trine H Mogensen
Inborn errors of immunity can underlie susceptibility to severe viral infection in humans. and the majority relate to defective induction of or response to antiviral type I interferon (IFN). However there is increasing awareness of defects ...