Targeting the virus-host interface for the development of therapeutics against filoviruses [0.03%]
针对病毒-宿主界面的靶点研发治疗(filio)病毒感染药物
Juliette Dupré,Molly A Vickers,Allison Groseth et al.
Juliette Dupré et al.
Until relatively recently, treatment for filovirus infections was limited to supportive care measures, but the occurrence of several large outbreaks in past years, including a multinational epidemic in West Africa from 2013 to 2016, has spu...
Alcaligenes lipid A: a unique TLR4 agonist mucosal adjuvant inducing secretory IgA and Th17 responses [0.03%]
阿醋酸钙不动杆菌脂多糖：一种独特的TLR4黏膜佐剂诱导分泌型IgA和Th17应答
Ken Yoshii,Jun Kunisawa
Ken Yoshii
The COVID-19 pandemic has underscored the importance of infectious disease control. In this context, intensive efforts are underway to develop novel vaccine modalities that will enable the production of effective and safe vaccines in prepar...
Flavivirus NS1 as a pivotal virulence factor and a tractable target for next-generation antivirals, vaccines, and immunodiagnostics [0.03%]
黄病毒NS1是重要的毒力因子和新一代抗病毒药物、疫苗及免疫诊断试剂的潜在靶点
Yaoguang Huang,Ting He,Po Ying Chia et al.
Yaoguang Huang et al.
Flavivirus nonstructural protein 1 (NS1) is a secreted glycoprotein that is pivotal to viral replication and pathogenesis in dengue, Zika, yellow fever, and other flaviviral infections. Recent structural studies reveal that NS1 can adopt mu...
Respiratory syncytial virus (RSV) and influenza A virus (IAV) interplay with the type I and III interferon (IFN) responses in the respiratory epithelium [0.03%]
呼吸道合胞病毒(RSV)和流感A病毒(IAV)与I型和III型干扰素(IFN)在呼吸道上皮中的相互作用
Romane Fernandez,Manuel Rosa-Calatrava,Andrés Pizzorno
Romane Fernandez
Respiratory Syncytial Virus (RSV) and Influenza A viruses (IAV) are major Public Health burdens, causing together worldwide morbidity and mortality across all age ranges. Respiratory viruses primarily enter and are transmitted through the u...
Ghazal Sodaifi,Mihai G Netea
Ghazal Sodaifi
Recent studies have revealed that cells of the innate immune system can adapt to previous insults (such as infections) and build a de-facto innate immune memory termed trained immunity. This process enables enhanced responses to homologous ...
Lessons from mycobacteria: development and design of Mincle-targeting adjuvants [0.03%]
结核杆菌的启示：髓系细胞耐受性活化受体配基的筛选与设计
Shigenari Ishizuka,Sho Yamasaki
Shigenari Ishizuka
Host defense against intracellular pathogens, including viruses and mycobacteria, requires not only antibody production but also T cell-mediated cellular immunity, which is often overlooked in current vaccine strategies. C-type lectin recep...
Minami Kojima,Daisuke Ori,Taro Kawai
Minami Kojima
Vaccine adjuvants are increasingly recognized to modulate immune responses not through single pattern-recognition receptors, but through broader cellular stress responses that lead to innate immune activation. Damage-associated molecular pa...
Hijacked highways: plant virus modulation of vector proteins from entry to exit [0.03%]
植物病毒对介体蛋白的操纵：从进入至退出
Arinder K Arora,Udvashika Puri,Kiran R Gadhave
Arinder K Arora
Plant viruses rely on insect vectors to complete their transmission cycles, exploiting a diverse array of vector proteins to enable entry, intracellular movement, replication, and exit. This review synthesizes recent advances in our underst...
The molecular arms race: mechanisms of fungal antiviral defense and viral counterstrategies [0.03%]
分子军备竞赛：真菌抗病毒防御机制及其病毒反击策略
Gudam Kwon,Jisuk Yu,Kook-Hyung Kim
Gudam Kwon
Advances in high-throughput sequencing have accelerated the discovery of novel mycoviruses, shedding light on the dynamic coevolution between fungi and their viral partners. Recent studies indicate that mycoviruses act as key ecological dri...
Takumi Adachi,Etsushi Kuroda
Takumi Adachi
Adjuvants play an important role in vaccine efficacy by activating innate immune responses that effectively induce adaptive immunity. Since innate immune cells recognize pathogen-derived factors, such as pathogen-associated molecular patter...