Dissecting lipid nanoparticle adjuvanticity and reactogenicity to optimize vaccine formulations [0.03%]
剖析脂质纳米颗粒的佐剂作用和不良反应以优化疫苗配方
Toshiro Hirai,Yasuo Yoshioka
Toshiro Hirai
mRNA vaccines have been proven to be highly effective; however, they are often more reactogenic than several older platforms, and systemic symptoms can limit their acceptance. Lipid nanoparticles (LNPs) are at the center of this tradeoff; t...
TANK-binding kinase 1 (TBK1): unexpected cell type-specific immune regulation beyond antiviral type I interferon signaling [0.03%]
Tank结合 Kinase 1(TBK1): 不同于抗病毒Ⅰ型干扰素信号转导的意外的免疫调节作用
Mariana S Almeida,Jelena S Bezbradica,Cevayir Coban
Mariana S Almeida
Recognition of viral nucleic acids by multiple pattern-recognition receptors converges on TANK-binding kinase 1 (TBK1) to initiate type I interferon responses and antiviral immunity. While this canonical role is well established, recent stu...
Beyond hepatitis D virus: the discovery of animal deltaviruses, their diversity, helpers and their position in an expanding world of circular RNA replicons [0.03%]
丙型肝炎病毒之外：动物 deltavirus 的发现、多样性、辅助作用及其在环状 RNA 复制子的扩张世界中的地位
Zoé Denis,Valérie Courgnaud,Karim Majzoub
Zoé Denis
Hepatitis D virus (HDV) was long considered a singular human satellite virus that depends on hepatitis B virus (HBV) for envelopment and transmission. Recent metatranscriptomic mining has uncovered a growing diversity of HDV-like viruses, w...
Adjuvant databases and knowledge bases for data-driven research: a computational biology perspective [0.03%]
从计算生物学角度看待辅助数据库和知识库：数据驱动型研究的需要
Yayoi Natsume-Kitatani
Yayoi Natsume-Kitatani
In adjuvant research, which has long relied on experience and trial and error, advancements in technologies in broad areas, including artificial intelligence (AI)/machine learning, enabling data-driven research, have supported the introduct...
Human genetic and immunological determinants of Epstein-Barr virus-driven disease [0.03%]
驱动EB病毒性疾病的遗传和免疫学决定因素
Antoine Gondé,Benjamin Fournier,Sylvain Latour
Antoine Gondé
Epstein-Barr virus (EBV) infects the vast majority of humans and establishes lifelong latency, yet causes disease in only a minority of individuals, underscoring the critical role of host determinants. This review examines the recent advanc...
Dorian C Dederko,Ed C Lavelle
Dorian C Dederko
While injectable vaccines can prevent respiratory pathogens from causing severe disease, their ability to elicit protective local immunity in the respiratory mucosa is more limited. For viral pathogens, infection outcome is often determined...
Abraham Awada,Christian W Thorball,Valeriia Timonina et al.
Abraham Awada et al.
Human Immunodeficiency Virus Type 1 (HIV-1) continues to pose a significant global public health challenge. Marked inter-individual variability in susceptibility to infection, viral load, and disease progression has long highlighted an impo...
Targeting the virus-host interface for the development of therapeutics against filoviruses [0.03%]
针对病毒-宿主界面的靶点研发治疗(filio)病毒感染药物
Juliette Dupré,Molly A Vickers,Allison Groseth et al.
Juliette Dupré et al.
Until relatively recently, treatment for filovirus infections was limited to supportive care measures, but the occurrence of several large outbreaks in past years, including a multinational epidemic in West Africa from 2013 to 2016, has spu...
Alcaligenes lipid A: a unique TLR4 agonist mucosal adjuvant inducing secretory IgA and Th17 responses [0.03%]
阿醋酸钙不动杆菌脂多糖：一种独特的TLR4黏膜佐剂诱导分泌型IgA和Th17应答
Ken Yoshii,Jun Kunisawa
Ken Yoshii
The COVID-19 pandemic has underscored the importance of infectious disease control. In this context, intensive efforts are underway to develop novel vaccine modalities that will enable the production of effective and safe vaccines in prepar...
Flavivirus NS1 as a pivotal virulence factor and a tractable target for next-generation antivirals, vaccines, and immunodiagnostics [0.03%]
黄病毒NS1是重要的毒力因子和新一代抗病毒药物、疫苗及免疫诊断试剂的潜在靶点
Yaoguang Huang,Ting He,Po Ying Chia et al.
Yaoguang Huang et al.
Flavivirus nonstructural protein 1 (NS1) is a secreted glycoprotein that is pivotal to viral replication and pathogenesis in dengue, Zika, yellow fever, and other flaviviral infections. Recent structural studies reveal that NS1 can adopt mu...