Exploration of MAIT cell-activating ligands and their potential as vaccine adjuvants for infectious diseases [0.03%]
多产抗原刺激T细胞活化配体的探索及其作为传染病疫苗佐剂的潜力研究
Shinsuke Inuki
Shinsuke Inuki
Vaccine adjuvants play a critical role in enhancing the magnitude and quality of immune responses; however, limitations in the efficacy of current vaccines against certain infectious diseases, together with the ongoing emergence of new path...
Immunopathogenic insights into members of the class Bunyaviricetes: a comparative review of emerging zoonotic threats [0.03%]
bunyaviricetes类病毒的免疫病理见解：新兴人畜共患病威胁的比较评论
Mark Anthony B Casel,Nam-Hyuk Cho,Jae U Jung et al.
Mark Anthony B Casel et al.
The class Bunyaviricetes encompasses a diverse group of vector- and rodent-borne viruses, many of which are major human pathogens causing severe and often lethal diseases worldwide. These include Lassa fever virus (Arenaviridae), hantavirus...
STING agonists as next-generation vaccine adjuvants: mechanisms, opportunities, and challenges [0.03%]
新一代疫苗佐剂的TLR配体：机制、机遇与挑战
Burcu Temizoz,Ken J Ishii
Burcu Temizoz
Vaccine adjuvants shape the magnitude and quality of adaptive immune responses by engaging innate sensing pathways. Among emerging platforms, agonists of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway have g...
Dissecting lipid nanoparticle adjuvanticity and reactogenicity to optimize vaccine formulations [0.03%]
剖析脂质纳米颗粒的佐剂作用和不良反应以优化疫苗配方
Toshiro Hirai,Yasuo Yoshioka
Toshiro Hirai
mRNA vaccines have been proven to be highly effective; however, they are often more reactogenic than several older platforms, and systemic symptoms can limit their acceptance. Lipid nanoparticles (LNPs) are at the center of this tradeoff; t...
TANK-binding kinase 1 (TBK1): unexpected cell type-specific immune regulation beyond antiviral type I interferon signaling [0.03%]
Tank结合 Kinase 1(TBK1): 不同于抗病毒Ⅰ型干扰素信号转导的意外的免疫调节作用
Mariana S Almeida,Jelena S Bezbradica,Cevayir Coban
Mariana S Almeida
Recognition of viral nucleic acids by multiple pattern-recognition receptors converges on TANK-binding kinase 1 (TBK1) to initiate type I interferon responses and antiviral immunity. While this canonical role is well established, recent stu...
Beyond hepatitis D virus: the discovery of animal deltaviruses, their diversity, helpers and their position in an expanding world of circular RNA replicons [0.03%]
丙型肝炎病毒之外：动物 deltavirus 的发现、多样性、辅助作用及其在环状 RNA 复制子的扩张世界中的地位
Zoé Denis,Valérie Courgnaud,Karim Majzoub
Zoé Denis
Hepatitis D virus (HDV) was long considered a singular human satellite virus that depends on hepatitis B virus (HBV) for envelopment and transmission. Recent metatranscriptomic mining has uncovered a growing diversity of HDV-like viruses, w...
Adjuvant databases and knowledge bases for data-driven research: a computational biology perspective [0.03%]
从计算生物学角度看待辅助数据库和知识库：数据驱动型研究的需要
Yayoi Natsume-Kitatani
Yayoi Natsume-Kitatani
In adjuvant research, which has long relied on experience and trial and error, advancements in technologies in broad areas, including artificial intelligence (AI)/machine learning, enabling data-driven research, have supported the introduct...
Human genetic and immunological determinants of Epstein-Barr virus-driven disease [0.03%]
驱动EB病毒性疾病的遗传和免疫学决定因素
Antoine Gondé,Benjamin Fournier,Sylvain Latour
Antoine Gondé
Epstein-Barr virus (EBV) infects the vast majority of humans and establishes lifelong latency, yet causes disease in only a minority of individuals, underscoring the critical role of host determinants. This review examines the recent advanc...
Dorian C Dederko,Ed C Lavelle
Dorian C Dederko
While injectable vaccines can prevent respiratory pathogens from causing severe disease, their ability to elicit protective local immunity in the respiratory mucosa is more limited. For viral pathogens, infection outcome is often determined...
Abraham Awada,Christian W Thorball,Valeriia Timonina et al.
Abraham Awada et al.
Human Immunodeficiency Virus Type 1 (HIV-1) continues to pose a significant global public health challenge. Marked inter-individual variability in susceptibility to infection, viral load, and disease progression has long highlighted an impo...