Tom C Hobman,Craig McCormick
Tom C Hobman
Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance [0.03%]
单纯疱疹病毒感染的当前及未来治疗方案：作用机制和药物抗性
Scott H James,Mark N Prichard
Scott H James
Forty years after the discovery of acyclovir (ACV), it remains the mainstay of therapy for herpes simplex virus (HSV) infections. Since then, other antiviral agents have also been added to the armamentarium for these infections but ACV rema...
Leonardus M I Koharudin,Angela M Gronenborn
Leonardus M I Koharudin
A growing class of potential antivirals encompasses carbohydrate-binding proteins, such as antibodies and lectins. They block virus entry into host target cells and halt virus transmission from virus-infected cells to non-infected cells, th...
Jacques Le Pendu,Kristina Nyström,Nathalie Ruvoën-Clouet
Jacques Le Pendu
Noroviruses and rotavirus A bind to polymorphic glycans of the histo-blood group type (HBGAs). Norovirus strains that bind to HBGAs can collectively infect all humans but each strain only infects a subgroup of the population, suggesting a p...
Adeyemi O Adedeji,Stefan G Sarafianos
Adeyemi O Adedeji
Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these vir...
David F Smith,Richard D Cummings
David F Smith
While all viruses must transit the plasma membrane of mammalian cells to initiate infection, we know little about the complex processes involved in viral attachment, which commonly involve recognition of glycans by viral proteins. Glycan mi...
Glycan receptors of the Polyomaviridae: structure, function, and pathogenesis [0.03%]
Polyomavirus糖受体的结构、功能和致病机理
Samantha D O&#x;Hara,Thilo Stehle,Robert Garcea
Samantha D O&#x;Hara
Multiple glycans have been identified as potential cell surface binding motifs for polyomaviruses (PyVs) using both crystallographic structural determinations and in vitro binding assays. However, binding alone does not necessarily imply th...
Celia Perales,Nathan M Beach,Julie Sheldon et al.
Celia Perales et al.
Resistance to interferon (IFN) in hepatitis C virus (HCV) differs from resistance to standard, directly-acting antiviral (DAA) agents in that the virus confronts a multicomponent antiviral state evoked by IFN. This renders unlikely the repe...
Editorial overview: viral pathogenesis: dealing with complexity in virus-induced disease [0.03%]
导语：病毒发病机理：应对病毒感染引起的复杂疾病
Mark T Heise
Mark T Heise
Matthew Frieman
Matthew Frieman