Luca D Bertzbach,Wing-Hang Ip,Konstantin von Stromberg et al.
Luca D Bertzbach et al.
Oncogenic viruses contribute to 15% of global human cancers. To achieve that, virus-encoded oncoproteins deregulate cellular transcription, antagonize common cellular pathways, and thus drive cell transformation. Notably, adenoviruses were ...
Role of mucosal-associated invariant T cells in coronavirus disease 2019 vaccine immunogenicity [0.03%]
黏膜相关不变T细胞在新型冠状病毒疾病2019疫苗免疫原性中的作用
Ali Amini,Paul Klenerman,Nicholas M Provine
Ali Amini
Mucosal-associated invariant T (MAIT) cells are an unconventional T cell population that are highly abundant in humans. They possess a semi-invariant T cell receptor (TCR) that recognises microbial metabolites formed during riboflavin biosy...
Role of the intestinal microbiota in host defense against respiratory viral infections [0.03%]
肠道微生物群在宿主防御呼吸道病毒感染中的作用
Idia Boncheva,Johanne Poudrier,Emilia L Falcone
Idia Boncheva
Viral infections, including those affecting the respiratory tract, can alter the composition of the intestinal microbiota, which, in turn, can significantly influence both innate and adaptive immune responses, resulting in either enhanced p...
Delphine Bonhomme,Enzo Z Poirier
Delphine Bonhomme
Virus infection activates specific pattern recognition receptors and immune signal transduction, resulting in pro-inflammatory cytokine production and activation of innate immunity. We describe here the molecular organization of early signa...
Elena Stylianou,Iman Satti
Elena Stylianou
Bacille Calmette-Guérin (BCG) remains the sole licensed vaccine against tuberculosis (TB), despite its variable efficacy in protecting against pulmonary TB. The development of effective TB vaccines faces significant challenges, marked by t...
Journey of monocytes and macrophages upon influenza A virus infection [0.03%]
甲型流感病毒感染中的单核细胞和巨噬细胞的分化迁移路径
Cecilia Ruscitti,Coraline Radermecker,Thomas Marichal
Cecilia Ruscitti
Influenza A virus (IAV) infections pose a global health challenge that necessitates a comprehensive understanding of the host immune response to devise effective therapeutic interventions. As monocytes and macrophages play crucial roles in ...
A complex immune communication between eicosanoids and pulmonary macrophages [0.03%]
白细胞介素与肺巨噬细胞之间的复杂免疫通信
Erwan Pernet,Jeremie Poschmann,Maziar Divangahi
Erwan Pernet
Respiratory viral infections represent a constant threat for human health and urge for a better understanding of the pulmonary immune response to prevent disease severity. Macrophages are at the center of pulmonary immunity, where they play...
Mechanisms of mucosal immunity at the female reproductive tract involved in defense against HIV infection [0.03%]
女性生殖道中参与防御HIV感染的粘膜免疫机制
Margaret Wy Choi,Carmina A Isidoro,Amy Gillgrass
Margaret Wy Choi
Human immunodeficiency virus-1 remains a major global health threat. Since the virus is often transmitted through sexual intercourse and women account for the majority of new infections within the most endemic regions, research on mucosal i...
Tissue-resident memory T cells in protective immunity to influenza virus [0.03%]
保护性免疫中的组织驻留记忆T细胞——以流感病毒为例
Seungwoo Lee,Karen Km Yeung,Tania H Watts
Seungwoo Lee
Influenza virus is an important human pathogen with significant pandemic potential. Tissue-resident memory T cells (Trm) in the lung provide critical protection against influenza, but unlike Trm at other mucosal sites, Trm in the respirator...
Tao Wang,Yanling Wang,Jinjing Zhang et al.
Tao Wang et al.
Mucosal tissues are frequent targets of both primary and metastatic cancers. This has highlighted the significance of both innate and adaptive anti-cancer immunity at mucosal sites. Trained innate immunity (TII) is an emerging concept defin...