Tissue-resident memory T cells in protective immunity to influenza virus [0.03%]
保护性免疫中的组织驻留记忆T细胞——以流感病毒为例
Seungwoo Lee,Karen Km Yeung,Tania H Watts
Seungwoo Lee
Influenza virus is an important human pathogen with significant pandemic potential. Tissue-resident memory T cells (Trm) in the lung provide critical protection against influenza, but unlike Trm at other mucosal sites, Trm in the respirator...
Tao Wang,Yanling Wang,Jinjing Zhang et al.
Tao Wang et al.
Mucosal tissues are frequent targets of both primary and metastatic cancers. This has highlighted the significance of both innate and adaptive anti-cancer immunity at mucosal sites. Trained innate immunity (TII) is an emerging concept defin...
Philip Lawrence,Michelle Heung,Julia Nave et al.
Philip Lawrence et al.
Over the last decade, the emergence of several zoonotic viruses has demonstrated that previously unknown or neglected pathogens have the potential to cause epidemics and therefore to pose a threat to global public health. Even more concerni...
Pathogenesis of severe acute respiratory syndrome coronavirus-2 in nonhuman primates [0.03%]
非人灵长类动物中的严重急性呼吸系统综合症冠状病毒2型的发病机理
Taylor Saturday,Neeltje van Doremalen
Taylor Saturday
The continued pressure of COVID-19 on public health worldwide underlines the need for a better understanding of the mechanisms of disease caused by severe acute respiratory syndrome coronavirus-2. Though many animal models are readily avail...
Jelle Matthijnssens,Evelien Adriaenssens
Jelle Matthijnssens
Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs? [0.03%]
严重急性呼吸系统综合症冠状病毒从人类传染至动物：是否会形成新的病毒库？
Leira Fernández-Bastit,Júlia Vergara-Alert,Joaquim Segalés
Leira Fernández-Bastit
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoonotic virus able to infect humans and multiple nonhuman animal species. Most natural infections in companion, captive zoo, livestock, and wildlife species have been relate...
Hepatitis-B virus: replication cycle, targets, and antiviral approaches [0.03%]
乙型肝炎病毒：复制周期、靶点及抗病毒方法
Nour Nasser,Pierre Tonnerre,Abdellah Mansouri et al.
Nour Nasser et al.
An estimated 257 million people are chronic carriers of hepatitis-B virus (HBV) infection, which resulted in around 1 million deaths, mainly due to hepatocellular carcinoma (HCC). Long-term nucleotide analog treatment of HBV infection is as...
Belén Carriquí-Madroñal,Lisa Lasswitz,Thomas von Hahn et al.
Belén Carriquí-Madroñal et al.
Hepatitis-C virus (HCV) chronically infects 58 million individuals worldwide with variable disease outcome. While a subfraction of individuals exposed to the virus clear the infection, the majority develop chronic infection if untreated. An...
Role of the viral polymerase during adaptation of influenza A viruses to new hosts [0.03%]
病毒聚合酶在流感病毒适应新宿主过程中所起的作用
Brad Gilbertson,Melanie Duncan,Kanta Subbarao
Brad Gilbertson
As a group, influenza-A viruses (IAV) infect a wide range of animal hosts, however, they are constrained to infecting selected host species by species-specific interactions between the host and virus, that are required for efficient replica...
The role of nuclear pores and importins for herpes simplex virus infection [0.03%]
核孔和导入蛋白在单纯疱疹病毒感染中的作用
Katinka Döhner,Manutea C Serrero,Beate Sodeik
Katinka Döhner
Microtubule transport and nuclear import are functionally connected, and the nuclear pore complex (NPC) can interact with microtubule motors. For several alphaherpesvirus proteins, nuclear localization signals (NLSs) and their interactions ...