Suan-Sin Foo,Weiqiang Chen
Suan-Sin Foo
Hera Fatima,Abel Viejo-Borbolla,Thomas Krey
Hera Fatima
The complement system constitutes a powerful antiviral defense, centered on C3b-mediated amplification that drives opsonization, inflammation, and membrane attack complex formation. To persist in the eukaryotic host, viruses must neutralize...
The HEV capsid through a dynamic lens: parallels and divergence from caliciviruses [0.03%]
HEV衣壳的动态模型及其与杯状病毒的异同点
Nachiket Moti,Thomas Peters
Nachiket Moti
The hepatitis E virus (HEV) capsid protein, pORF2, mediates virion assembly, attachment and entry, yet the molecular mechanisms underlying these processes remain poorly defined. Structural studies have provided high-resolution views of pORF...
When structural rationales fall short: revisiting the immunogenicity of herpesvirus prefusion and postfusion glycoprotein B [0.03%]
当结构理据不足时：重新审视疱疹病毒前融合和后融合糖蛋白B的免疫原性
Julia Nentwig,Kay Grünewald,Benjamin Vollmer
Julia Nentwig
The concept of stabilising viral fusion proteins in their prefusion conformation to focus immunogenicity has driven vaccine research across many viruses. However, for herpesviruses, recent findings suggest that this approach may not yield t...
Beyond brain fog: viral proteins as convergent drivers of neuroinflammation and proteinopathy [0.03%]
超越脑雾：病毒蛋白作为神经炎症和蛋白质病的汇聚驱动因素
Christopher Käufer,Rebecca Kotzur,Kristina Lau et al.
Christopher Käufer et al.
Post-viral neurological syndromes, such as post-acute sequelae of COVID-19, present a paradox of severe symptoms despite minimal CNS viral replication. The 'protein-as-pathogen' model, where shed viral proteins act as soluble neurotoxins, i...
Use of age-specific human in vitro platforms to advance discovery and development of novel vaccine adjuvants [0.03%]
利用年龄特异性的人类体外平台推进新型疫苗佐剂的发现和开发
Sanya Thomas,Simon van Haren,Ofer Levy
Sanya Thomas
Populations that are particularly vulnerable to infections, such as neonates, infants, and older adults, exhibit distinct immunological profiles contributing to sub-optimal responses to conventional vaccines. Historically, vaccine developme...
Human Genetic and Immunological Determinants of Resistance or Susceptibility to Viral Infections: Evolutionary and Medical Insights [0.03%]
人类遗传和免疫学决定因素决定了对病毒感染的抵抗力或易感性：进化和医学见解
Trine H Mogensen,Jean-Laurent Casanova
Trine H Mogensen
Molecular mechanisms of NS2pro activation in hepaciviruses and pestiviruses: regulation, intrinsic activity, and structural determinants [0.03%]
hepacivirus和pestivirus中NS2pro激活的分子机制：调控、内在活性及结构决定因素
Olaf Isken,Malte Morische,Norbert Tautz
Olaf Isken
Replication of all positive strand-RNA viruses depends on translation of a viral polyprotein, which is cleaved by viral and/or cellular proteases. The nonstructural protein 2 (NS2) of hepaciviruses and pestiviruses is responsible for NS2-NS...
Niklas Ebersberger,Gabrielle Vieyres,Thomas Krey
Niklas Ebersberger
Hepatitis C virus (HCV) exploits the physiological pathways of lipid uptake and transport via utilization of several lipoprotein receptors, including the low-density lipoprotein receptor (LDLR), very low-density lipoprotein receptor (VLDLR)...
Next-Generation vaccine adjuvants: NIAID perspective on mechanistic insights and emerging strategies [0.03%]
下一代疫苗佐剂：NIAID对作用机制见解和新兴策略的展望
Halonna R Kelly,Wolfgang W Leitner
Halonna R Kelly
Vaccine adjuvants play a central role in shaping the magnitude, quality, and durability of vaccine-induced immune responses, yet their rational design and selection remain major challenges. Although the adjuvant repertoire has expanded subs...