The lncRNA DSCR9 is modulated in pulmonary arterial hypertension endothelial cell models and is associated with alterations in the nitric oxide pathway [0.03%]
长链非编码RNA DSCR9在肺动脉高压内皮细胞模型中被调控并与一氧化氮通路改变相关
N Bernardi,B F Neep,S Garibaldi et al.
N Bernardi et al.
Long non-coding RNA (lncRNA) may be involved in dysfunction of pulmonary artery endothelial cells (PAEC) and, thus, in pulmonary arterial hypertension (PAH) pathobiology. We screened the RNA expression profile of commercial human PAEC (hPAE...
Stay connected: The myoendothelial junction proteins in vascular function and dysfunction [0.03%]
连接不止：肌层内皮细胞间连接蛋白在血管功能与功能障碍中的作用
Giulia Querio,Federica Geddo,Susanna Antoniotti et al.
Giulia Querio et al.
The appropriate regulation of peripheral vascular tone is crucial for maintaining tissue perfusion. Myoendothelial junctions (MEJs), specialized connections between endothelial cells and vascular smooth muscle cells, are primarily located i...
Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging [0.03%]
阐明心血管衰老过程中诱导内皮功能障碍的新兴信号通路
Anna De Bartolo,Tommaso Angelone,Carmine Rocca
Anna De Bartolo
The risk for developing cardiovascular diseases dramatically increases in older individuals, and aging vasculature plays a crucial role in determining their morbidity and mortality. Aging disrupts endothelial balance between vasodilators an...
Zuhayr Jafri,Jingwen Zhang,Connor H O&#x;Meara et al.
Zuhayr Jafri et al.
Immune checkpoint therapy targeting the PD-1/PD-L1 axis has revolutionized the treatment of solid tumors. However, T cell exhaustion underpins resistance to current anti-PD-1 therapies, resulting in lower response rates in cancer patients. ...
Sexual dimorphism in aortic aneurysm: A review of the contributions of sex hormones and sex chromosomes [0.03%]
主动脉瘤的性别二态性：性激素和性染色体贡献的综述
Hao-Nan Chen,Yan-Ni Hu,Li-Ling Ran et al.
Hao-Nan Chen et al.
Aortic aneurysm is a common cardiovascular disease. Over time, the disease damages the structural and functional integrity of the aorta, causing it to abnormally expand and potentially rupture, which can be fatal. Sex differences are eviden...
J Anakha,Yenisetti Rajendra Prasad,Abhay H Pande
J Anakha
Angiogenesis plays a pivotal role in various pathological conditions, making it a key target in therapeutic development. Anti-angiogenic therapies are gaining traction for their potential in treating a range of angiogenesis-dependent diseas...
Targeting the Ca2+ signaling toolkit as an alternative strategy to mitigate SARS-CoV-2-induced cardiovascular adverse events [0.03%]
针对钙信号转导通路作为减轻新冠病毒引起的心血管不良事件的潜在策略
Simona Scorza,Valentina Brunetti,Giorgia Scarpellino et al.
Simona Scorza et al.
Ca2+ signaling events are essential for maintaining cardiovascular health, regulating critical functions in both endothelial and cardiac cells. SARS-CoV-2 infection impinges this delicate balance, leading to severe cardiovascular complicati...
The role of Epsins in atherosclerosis: From molecular mechanisms to therapeutic applications [0.03%]
Epsin在动脉粥样硬化中的作用：从分子机制到治疗应用
Siarhei A Dabravolski,Alexey V Churov,Alessio L Ravani et al.
Siarhei A Dabravolski et al.
Atherosclerosis is a multifaceted disease characterised by chronic inflammation and vascular remodelling, leading to plaque formation and cardiovascular complications. Recent evidence highlights the critical role of epsins, a family of endo...
Unravelling molecular mechanisms in atherosclerosis using cellular models and omics technologies [0.03%]
利用细胞模型和组学技术解构动脉粥样硬化的分子机制
Dimitris Kardassis,Cécile Vindis,Camelia Sorina Stancu et al.
Dimitris Kardassis et al.
Despite the discovery and prevalent clinical use of potent lipid-lowering therapies, including statins and PCSK9 inhibitors, cardiovascular diseases (CVD) caused by atherosclerosis remain a large unmet clinical need, accounting for frequent...
Prevalence of antiphospholipid antibodies in COVID-19 patients: A meta-analysis [0.03%]
新型冠状肺炎患者的抗磷脂抗体流行率：一项系统综述和meta分析
Er Jin,Bei Li,Xiaonan Wang et al.
Er Jin et al.
Objective: In some reports, antiphospholipid antibodies (aPL) prevalence is higher in COVID-19 patients. This study intended to compare aPL prevalence between COVID-19 patients and healthy controls, and differences in aPL...