Vascular diameter determines sensitivity to soluble guanylate cyclase activation in human mesenteric and renal arteries [0.03%]
血管直径决定了解偶联鸟苷酸环化酶激活的人肠系膜和肾动脉敏感性
Lubomir T Lubomirov,Simon Jasinski-Bergner,Kangbo Li et al.
Lubomir T Lubomirov et al.
Objective: This study tested if arterial reactivity to soluble guanylate cyclase (sGC)/protein kinase G (PKG) pathway activation depends on age, vessel localization as well as diameter and investigated the molecular mecha...
Pharmacological activation of NO-sensitive guanylyl cyclase ameliorates obesity-induced arterial stiffness [0.03%]
药理学激活一氧化氮敏感的鸟苷酸环化酶可改善肥胖引起的动脉僵硬度
Enkhjargal Budbazar,Aylin Balmes,Danielle Elliott et al.
Enkhjargal Budbazar et al.
Background & purpose: Arterial stiffness, or loss of elastic compliance in large arteries, is an independent precursor of cardiovascular disease (CVD) [1] and dementia [2] for which currently there are no targeted therapi...
Lucas Tramujas,Alleh Nogueira,Nicole Felix et al.
Lucas Tramujas et al.
Miron Sopić,Tijana Mitić,Judith Sluimer et al.
Miron Sopić et al.
Single-cell RNA sequencing (scRNA-seq) and its insights into cellular heterogeneity in atherosclerosis [0.03%]
单细胞RNA测序及其在动脉粥样硬化细胞异质性研究中的应用展望
Baixue Yu,Miron Sopic,Judith C Sluimer
Baixue Yu
Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of cellular diversity in human biology, providing novel insights into disease mechanisms. In cardiovascular disease (CVD), scRNA-seq enables precise mapping of complex...
The use of glycoprotein IIb/IIIa inhibitors in elective PCI - A systematic review and meta-analysis of randomised trials [0.03%]
选期PCI中使用糖蛋白IIb/IIIa受体抑制剂的系统评价和meta分析研究
Daniel G Brieger,Karan Rao,Vinayak Nagaraja et al.
Daniel G Brieger et al.
Background: Glycoprotein IIb/IIIa inhibitors (GPIs) improve 30-day outcomes when used as an adjunct to percutaneous coronary intervention (PCI) in acute coronary syndromes, but their role in stable coronary artery disease...
Endothelial-to-mesenchymal transition gene signature derived from single-cell transcriptomics of human atherosclerotic tissue associates with stable plaque histological characteristics [0.03%]
基于单细胞转录组学的内皮-间充质转化基因谱系与动脉粥样硬化斑块表型相关性研究
Lotte Slenders,Marian Wesseling,Siting Wei et al.
Lotte Slenders et al.
Background: Endothelial cells within atherosclerotic plaques can differentiate into a mesenchymal-like phenotype through endothelial-to-mesenchymal transition (EndoMT). Our understanding of the molecular mechanisms underl...
Exploring the interplay between valvular and serum zinc and copper levels and disease markers in aortic stenosis [0.03%]
探讨主动脉瓣狭窄患者主动脉瓣与血清锌、铜水平及疾病标志物之间的相互作用
Bartłomiej Perek,Piotr Rzymski,Aleksandra Proch et al.
Bartłomiej Perek et al.
Aortic stenosis (AS) is a progressive condition characterized by valve calcification and significant morbidity, often requiring invasive intervention. The AS pathophysiology is multifaceted, with evidence suggesting a role for trace element...
Ceramide-based risk score: A novel laboratory tool for cardiovascular risk stratification in hyperuricemia and gout [0.03%]
基于神经酰胺的危险评分：在高尿酸血症和痛风中用于心血管风险分层的新实验室工具
Aleš Kvasnička,David Friedecký,Barbora Piskláková et al.
Aleš Kvasnička et al.
Gout and hyperuricemia increase cardiovascular disease risk, highlighting the need for improved risk stratification. In this pilot study, we evaluated the Coronary Event Risk Test (CERT) in 94 hyperuricemic and 196 gout patients, and 53 con...
Epitranscriptomics in atherosclerosis: Unraveling RNA modifications, editing and splicing and their implications in vascular disease [0.03%]
表观转录组学在动脉粥样硬化中的作用：揭示RNA修饰、编辑和剪切及其对血管疾病的影响
Victoria Stopa,Dimitra Dafou,Korina Karagianni et al.
Victoria Stopa et al.
Atherosclerosis remains a leading cause of morbidity and mortality worldwide, driven by complex molecular mechanisms involving gene regulation and post-transcriptional processes. Emerging evidence highlights the critical role of epitranscri...