Akiko Hata,Bengisu Gur,Jaspreet Kalra et al.
Akiko Hata et al.
Pulmonary veno-occlusive disease (PVOD) is a subtype of pulmonary hypertension (PH) with a poor prognosis. Patients with PVOD develop a gradual increase in pulmonary vascular resistance (PVR) and right heart failure. PVOD can occur sporadic...
The chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1) localize to ependymal cilia in brain ventricles [0.03%]
趋化因子受体CXCR4及其配体CXCL12（SDF-1）定位于脑室脉络丛纤毛上
Shahram Eisa-Beygi,Kulandaisamy Arulsamy,Kui Cui et al.
Shahram Eisa-Beygi et al.
Mesenchymal progenitor cells in perivascular niches: forerunners of mesenchymal stem cells and players in tissue scarring and regeneration [0.03%]
血管周围生态位中的间充质前体细胞：间充质干细胞的前身和组织瘢痕及再生的参与者
Neelima Thottapillil,Mirko Corselli,Ian Murray et al.
Neelima Thottapillil et al.
The walls of all embryonic, foetal, and adult blood vessels contain mesodermal progenitors, distributed as pericytes in capillaries and micro vessels, and fibroblastic cells in the tunica adventitia of larger veins and arteries. Following d...
Multi-omics identification of quantitative trait loci associated with vascular pathogenesis and diagnostic potential in chronic venous disease [0.03%]
多组学识别与慢性静脉疾病血管发病机制和诊断潜力相关的数量性状位点
Cheng-Hsun Chuang,Hsiao-Hsuan Huang,Yi-Syuan Wu et al.
Cheng-Hsun Chuang et al.
Chronic venous disease (CVD) is a prevalent vascular disorder with a poorly characterized genetic basis. In this study, we employed an integrative omics strategy combining genome-wide association studies (GWAS), expression quantitative trai...
Sodium-glucose cotransporter 2 inhibition restores testicular microvascular perfusion via endothelial signaling in a large animal model of metabolic syndrome and heart failure [0.03%]
钠葡萄糖共转运蛋白2抑制剂通过内皮信号转导恢复代谢综合征和心力衰竭大动物模型的睾丸微血管灌注
Jad Hamze,Christopher Stone,Dwight Douglas Harris et al.
Jad Hamze et al.
Objective: This study evaluates the effects of sodium-glucose cotransporter 2 (SGLT2) inhibition on testicular microvascular function and vascular signaling pathways in a swine model of metabolic syndrome (MetS) and ische...
Balancing act: Drp1 inhibition and mitochondrial homeostasis in cardiovascular diseases [0.03%]
心肌线粒体动力蛋白Drp1抑制与心脏能量代谢和疾病防治的关系及其机制研究
Nandini Dubey,Ahsas Goyal,Neeraj Parakh et al.
Nandini Dubey et al.
The heart is an organ that depends significantly on mitochondria to operate, since it requires a lot of energy, which mitochondria create, making them essential for the efficient functioning of the heart. The term "mitochondrial dynamics" r...
Evaluation of non-invasive low-risk criteria in patients with connective tissue disease-associated pulmonary arterial hypertension: A 12-months analysis from the INSPECTIO study [0.03%]
评估结缔组织病相关肺动脉高压患者的非侵入性低风险标准：INSPECTIO研究的12个月分析
Livio Giuliani,Michele D&#x;Alto,Emma Di Poi et al.
Livio Giuliani et al.
Background: Connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) is a progressive, high-risk subtype of PAH characterized by immune-mediated vascular remodeling, poor treatment response, and redu...
Unveiling the role of STAT1-activated macrophages in abdominal aortic aneurysm: Insights from scRNA-seq and prognostic signature development [0.03%]
揭秘STAT1激活的巨噬细胞在腹主动脉瘤中的作用：单细胞RNA测序和预后标志物开发的新见解
Yihui Chen,Baoxing Wu,Shichai Hong
Yihui Chen
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disorder with no effective drug treatment. Inflammation and macrophage infiltration in the abdominal aorta play a pivotal role in AAA development, progression, and rupture...
Masharh Lipscomb,Ignacia Salfate Del Rio,Maya Eid et al.
Masharh Lipscomb et al.
Atherosclerosis is a non-resolving inflammatory disease, and mechanisms to promote inflammation resolution, reduce vascular injury and promote repair in atherosclerosis are unmet needs. Specialized pro-resolving mediators (SPMs), like Resol...
Translational aspects of doxorubicin-induced cardiotoxicity: What we have omitted for the past decades? [0.03%]
译文：关于多柔比星引起的心脏毒性的转化医学方面：我们忽视了什么？
Ashot Avagimyan,Rosalinda Madonna,Mohammad Sheibani et al.
Ashot Avagimyan et al.
Anthracyclines remain the cornerstone of treatment for malignancies with dose-dependent cardiac damage, ranging from oxidative stress and mitochondrial dysfunction to DNA damage and ferroptosis, and continue to compromise patient outcome. A...